专利检索 ap:("BIOTRANSPLANT, INC") AND inv:"ROSA, Margaret, D." 第 1 页

1.

发明授权
ENHANCEMENT OF XENOGRAFT TOLERANCE AND PORCINE CYTOKINES THEREFOR 失效
标题翻译：提高移植耐受猪细胞因子

公开(公告)号：EP0669829B1

公开(公告)日：2001-08-08

申请号：EP93925071.8

申请日：1993-10-26

申请人： BIOTRANSPLANT, INC

发明人： PONATH, Paul, D. , ROSA, Margaret, D. , MONROY, Rodney, L. , SCHACTER, Bernice, Z. , HAWLEY, Robert, J.

IPC分类号： C12N15/19 , C12N15/62 , A61K35/28 , C07K14/52 , A61K38/19 , C12N15/85 , C12N5/10

CPC分类号： A61K35/28 , A61K38/00 , A61K39/00 , A61K39/001 , C07K14/475 , C07K14/52 , C07K14/535 , C07K14/54 , C07K2319/00 , Y10S514/885

摘要： A method of enhancing tolerance of a porcine transplant in a xenogeneic recipient by administering porcine bone marrow cells to the recipient and of enhancing proliferation and engraftment of the porcine bone marrow cells by exposing said cells to at least one substantially pure porcine cytokine and porcine cytokines that are substantially free of other porcine proteins and preferentially enhance the proliferation and engraftment of porcine bone marrow cells in the presence of bone marrow cells of other species. Protein and DNA sequence(s) for such porcine cytokines.

2.

发明公开
ENHANCEMENT OF XENOGRAFT TOLERANCE AND PORCINE CYTOKINES THEREFOR 失效
标题翻译：提高移植耐受猪细胞因子。

公开(公告)号：EP0669829A1

公开(公告)日：1995-09-06

申请号：EP93925071.0

申请日：1993-10-26

申请人： BIOTRANSPLANT, INC

发明人： PONATH, Paul, D. , ROSA, Margaret, D. , MONROY, Rodney, L. , SCHACTER, Bernice, Z. , HAWLEY, Robert, J.

IPC分类号： C12N15 , A61K35 , A61K38 , A61K39 , A61P37 , C07H21 , C07K14 , C12N5 , C12P21 , C12R1

CPC分类号： A61K35/28 , A61K38/00 , A61K39/00 , A61K39/001 , C07K14/475 , C07K14/52 , C07K14/535 , C07K14/54 , C07K2319/00 , Y10S514/885

摘要： A method of enhancing tolerance of a porcine transplant in a xenogeneic recipient by administering porcine bone marrow cells to the recipient and of enhancing proliferation and engraftment of the porcine bone marrow cells by exposing said cells to at least one substantially pure porcine cytokine and porcine cytokines that are substantially free of other porcine proteins and preferentially enhance the proliferation and engraftment of porcine bone marrow cells in the presence of bone marrow cells of other species. Protein and DNA sequence(s) for such porcine cytokines.