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1.发明授权LO-CD2a ANTIBODY AND USES THEREOF FOR INHIBITING T CELL ACTIVATION AND PROLIFERATION 失效LO-CD2a抗体及其用于抑制T细胞活化和增殖的用途
公开(公告)号：EP0959899B9
公开(公告)日：2009-10-21
申请号：EP96930529.1
申请日：1996-08-16
发明人： BAZIN, Hervé , LATINNE, Dominique , KAPLAN, Ruth , KIEBER-EMMONS, Thomas , POSTEMA, Christina, E. , WHITE-SCHARF, Mary, E.
IPC分类号： A61K39/00 , A61K39/395 , A61K38/00 , A61K38/16 , C07K14/00 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/44 , C07K16/46 , C12P21/08
CPC分类号： C07K16/2806 , A61K38/00 , C07K2317/24
摘要： The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response in human patients, preferably, where the immune response is mediated by the activation and proliferation of T cells or natural killer cells. The administration of an effective amount of the LO-CD2a antibody to a human patient will prevent or inhibit graft rejection, graft versus host disease or autoimmune disease.
摘要翻译： 本发明涉及LO-CD2a抗体以及使用结合相同表位（或其一部分）的此类抗体或分子以预防和抑制人类患者中免疫应答的方法，优选地，其中免疫应答由 T细胞或自然杀伤细胞的活化和增殖。 向患者施用有效量的LO-CD2a抗体将预防或抑制移植排斥，移植物抗宿主病或自身免疫疾病。
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2.发明授权LO-CD2a ANTIBODY AND USES THEREOF FOR INHIBITING T CELL ACTIVATION AND PROLIFERATION 失效LO-CD2a抗体，以及它们对于T细胞活化和增殖的抑制使用
公开(公告)号：EP0959899B1
公开(公告)日：2009-05-27
申请号：EP96930529.1
申请日：1996-08-16
发明人： BAZIN, Hervé , LATINNE, Dominique , KAPLAN, Ruth , KIEBER-EMMONS, Thomas , POSTEMA, Christina, E. , WHITE-SCHARF, Mary, E.
IPC分类号： A61K39/00 , A61K39/395 , A61K38/00 , A61K38/16 , C07K14/00 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/44 , C07K16/46 , C12P21/08
CPC分类号： C07K16/2806 , A61K38/00 , C07K2317/24
摘要： The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response in human patients, preferably, where the immune response is mediated by the activation and proliferation of T cells or natural killer cells. The administration of an effective amount of the LO-CD2a antibody to a human patient will prevent or inhibit graft rejection, graft versus host disease or autoimmune disease.
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3.发明公开LO-CD2a ANTIBODY AND USES THEREOF FOR INHIBITING T CELL ACTIVATION AND PROLIFERATION 失效LO-CD2a抗体，以及它们对于T细胞活化和增殖的抑制使用
公开(公告)号：EP0959899A1
公开(公告)日：1999-12-01
申请号：EP96930529.0
申请日：1996-08-16
发明人： BAZIN, Hervé , LATINNE, Dominique , KAPLAN, Ruth , KIEBER-EMMONS, Thomas , POSTEMA, Christina, E. , WHITE-SCHARF, Mary, E.
CPC分类号： C07K16/2806 , A61K38/00 , C07K2317/24
摘要： The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response in human patients, preferably, where the immune response is mediated by the activation and proliferation of T cells or natural killer cells. The administration of an effective amount of the LO-CD2a antibody to a human patient will prevent or inhibit graft rejection, graft versus host disease or autoimmune disease.
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4.发明授权LO-CD2a ANTIBODY AND USES THEREOF FOR INHIBITING T CELL ACTIVATION AND PROLIFERATION 失效LO-CD2a抗体及其用途用于抑制T细胞活化和生长
公开(公告)号：EP1003552B1
公开(公告)日：2008-05-14
申请号：EP97936112.8
申请日：1997-07-18
发明人： BAZIN, Hervé , LATINNE, Dominique , KAPLAN, Ruth , KIEBER-EMMONS, Thomas , POSTEMA, Christina, E. , WHITE-SCHARF, Mary, E.
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2806 , A61K38/00 , C07K2317/24 , C07K2319/00
摘要： The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response in human patients, preferably, where the immune response is mediated by the activation and proliferation of T cells or natural killer cells. The administration of an effective amount of LO-CD2a antibody to a human patient will prevent or inhibit graft rejection, graft versus host disease or autoimmune disease.
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5.发明公开LO-CD2a ANTIBODY AND USES THEREOF FOR INHIBITING T CELL ACTIVATION AND PROLIFERATION 失效LO-CD2a抗体及其用途用于抑制T细胞活化和生长
公开(公告)号：EP1003552A1
公开(公告)日：2000-05-31
申请号：EP97936112.8
申请日：1997-07-18
发明人： BAZIN, Hervé , LATINNE, Dominique , KAPLAN, Ruth , KIEBER-EMMONS, Thomas , POSTEMA, Christina, E. , WHITE-SCHARF, Mary, E.
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2806 , A61K38/00 , C07K2317/24 , C07K2319/00
摘要： The present invention relates to a LO-CD2a antibody and methods of using such antibodies or molecules that bind to the same epitope (or a portion thereof) to prevent and inhibit an immune response in human patients, preferably, where the immune response is mediated by the activation and proliferation of T cells or natural killer cells. The administration of an effective amount of LO-CD2a antibody to a human patient will prevent or inhibit graft rejection, graft versus host disease or autoimmune disease.
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