公开(公告)号：EP1331919A2

公开(公告)日：2003-08-06

申请号：EP01966037.2

申请日：2001-08-21

申请人： BLOCK DRUG COMPANY, INC.

发明人： ESTRADA, David ,  FITZ, Benjamin, D. ,  MACIK, Jan, F. ,  NAPOLITANO, Neil, J. ,  SMETANA, Alfred, J. ,  SYNODIS, Joseph, D. ,  TRAMA, Michael, E.

IPC分类号： A61K7/16

CPC分类号： A61Q11/00 ,  A61K6/0017 ,  A61K8/19 ,  A61K8/8147 ,  A61K8/8158 ,  C08L33/06

摘要： A composition for the treatment of sensitive teeth comprising a suitable carrier and a desensitizing amount of: a) at least one tubule blocking agent, preferably a combination of two such agents; and b) a nerve desensitizing agent selected from the group consisting of at least one potassium salt, at least one strontium salt, and mixtures thereof, wherein the tubule blocking agent deposits or swells upon the dentinal surface and/or precipitates within the dentinal tubules, retaining a higher concentration of the nerve desensitizing agent at the exposed dentinal surface and within the dentinal tubules. The compositions may further contain a source of physiologically acceptable fluoride ion, such as stannous fluoride. Also disclosed are methods of using the subject compositions in the treatment of sensitive teeth.