公开(公告)号：EP0989839B1

公开(公告)日：2004-02-04

申请号：EP98925293.7

申请日：1998-06-05

申请人： BLOCK DRUG COMPANY INC.

发明人： WONG, Eddie ,  CLARKE, Hal, C. ,  GASMAN, Robert, C. ,  SMETANA, Alfred, J. ,  SYNODIS, Joseph

IPC分类号： A61K6/00 ,  C08F8/42 ,  C08K5/01 ,  C08L35/08

CPC分类号： A61K6/0026 ,  C08L35/08 ,  C08L33/08

摘要： A denture adhesive composition is disclosed and comprises a polymeric activator in an amount of up to about 3 percent by weight based on the total weight of the denture adhesive composition. This composition exhibits enhanced adhesive performance and reduces oozing and incidence of food occlusion. Also disclosed is a method of preparing a denture adhesive composition comprising: preparing a mixture which comprises a polymeric activator in an amount of up to about 3 percent by weight based on the total weight of the denture adhesive composition; forming a denture adhesive composition including the mixture; and recovering the denture adhesive composition. A method of making a denture adhesive composition more adhesive and less oozing is disclosed as well. This method comprises adding to the denture adhesive composition a polymeric activator in an amount of up to about 3 percent by weight based on the total weight of the denture adhesive composition.

公开(公告)号：EP1331919A2

公开(公告)日：2003-08-06

申请号：EP01966037.2

申请日：2001-08-21

申请人： BLOCK DRUG COMPANY, INC.

发明人： ESTRADA, David ,  FITZ, Benjamin, D. ,  MACIK, Jan, F. ,  NAPOLITANO, Neil, J. ,  SMETANA, Alfred, J. ,  SYNODIS, Joseph, D. ,  TRAMA, Michael, E.

IPC分类号： A61K7/16

CPC分类号： A61Q11/00 ,  A61K6/0017 ,  A61K8/19 ,  A61K8/8147 ,  A61K8/8158 ,  C08L33/06

摘要： A composition for the treatment of sensitive teeth comprising a suitable carrier and a desensitizing amount of: a) at least one tubule blocking agent, preferably a combination of two such agents; and b) a nerve desensitizing agent selected from the group consisting of at least one potassium salt, at least one strontium salt, and mixtures thereof, wherein the tubule blocking agent deposits or swells upon the dentinal surface and/or precipitates within the dentinal tubules, retaining a higher concentration of the nerve desensitizing agent at the exposed dentinal surface and within the dentinal tubules. The compositions may further contain a source of physiologically acceptable fluoride ion, such as stannous fluoride. Also disclosed are methods of using the subject compositions in the treatment of sensitive teeth.

公开(公告)号：EP0774949B1

公开(公告)日：2005-10-19

申请号：EP95928317.7

申请日：1995-08-07

申请人： BLOCK DRUG COMPANY, INC.

发明人： CLARKE, Hal, C. ,  AHN, Hyung-Kook ,  WONG, Eddie ,  GASMAN, Robert, C. ,  SMETANA, Alfred, J. ,  SYNODIS, Joseph

IPC分类号： A61K6/08 ,  C08F216/12 ,  C08F216/38 ,  C08L31/00 ,  C08L37/00

CPC分类号： A61K6/0026 ,  G01N19/04 ,  C08L35/08 ,  C08L1/286

摘要： A novel denture adhesive composition contains an adhesive mixture comprising sodium carboxymethyl cellulose and, either a partially neutralized sodium, magnesium, zinc mixed salt or a partially neutralized magnesium, zinc mixed salt of an alkyl vinyl ether maleic acid copolymer.

公开(公告)号：EP0966257B1

公开(公告)日：2005-04-13

申请号：EP97949708.8

申请日：1997-12-03

申请人： BLOCK DRUG COMPANY, INC.

发明人： RICCOBONO, Paul, X. ,  SMETANA, Alfred, J. ,  SYNODIS, Joseph

IPC分类号： A61K7/30

CPC分类号： A61Q11/02 ,  A61K8/02 ,  A61K8/0216 ,  A61K8/91

摘要： A denture cleansing agent containing a film forming material for preventing plaque formation. The denture cleansing agent may be a denture cleanser tablet, and the film forming material may be a polyoxyethylene oxide/vinyl acetate copolymer.

公开(公告)号：EP0869761A1

公开(公告)日：1998-10-14

申请号：EP95928318.0

申请日：1995-08-07

申请人： BLOCK DRUG COMPANY, INC.

发明人： SYNODIS, Joseph ,  SMETANA, Alfred, J. ,  GASMAN, Robert, C. ,  WONG, Eddie ,  CLARKE, Hal, C.

IPC分类号： A61K6 ,  C09J135 ,  C08L1

CPC分类号： C09J135/08 ,  C08L1/28 ,  C08L2666/26 ,  A61K6/0026 ,  C08L35/08

摘要： A denture adhesive composition contains a denture adhesive and a pharmacologically acceptable carrier in which the denture adhesive is a salt of a copolymer of maleic acid or anhydride and a 1 to 5 carbon atom alkyl vinyl ether having a specific viscosity of at least 4.0. The denture adhesive composition is used to adhere a denture to the oral mucosa.

公开(公告)号：EP0869761B1

公开(公告)日：2005-11-02

申请号：EP95928318.5

申请日：1995-08-07

申请人： BLOCK DRUG COMPANY, INC.

发明人： SYNODIS, Joseph ,  SMETANA, Alfred, J. ,  GASMAN, Robert, C. ,  WONG, Eddie ,  CLARKE, Hal, C.

IPC分类号： A61K6/087 ,  C08L1/28 ,  C08L35/08

CPC分类号： C09J135/08 ,  C08L1/28 ,  C08L2666/26 ,  A61K6/0026 ,  C08L35/08

摘要： A denture adhesive composition contains a denture adhesive and a pharmacologically acceptable carrier in which the denture adhesive is a salt of a copolymer of maleic acid or anhydride and a 1 to 5 carbon atom alkyl vinyl ether having a specific viscosity of at least 4.0. The denture adhesive composition is used to adhere a denture to the oral mucosa.

公开(公告)号：EP1246598A1

公开(公告)日：2002-10-09

申请号：EP00968105.7

申请日：2000-10-13

申请人： BLOCK DRUG COMPANY INC.

发明人： WONG, Eddie ,  GASMAN, Robert, Charles ,  SMETANA, Alfred, J. ,  SYNODIS, Joseph, D. ,  CLARKE, Hal, Christopher

IPC分类号： A61K6/00 ,  C09J135/08

CPC分类号： A61K6/0061 ,  A61K6/0067 ,  A61K6/0094 ,  C08F8/44 ,  C08L33/02 ,  C08L2666/04 ,  C09J135/08 ,  A61K6/0026 ,  C08L33/08 ,  C08L33/10 ,  C08L33/064 ,  C08L1/286 ,  C08L1/284 ,  C08L39/06

摘要： A denture adhesive composition is disclosed and comprises a polymeric activator in an amount of up to about 3 percent by weight based on the total weight of the denture adhesive composition; wherein the activator is selected from the group consisting of: poly(meth)acrylic acid, poly acrylic acid, polyitaconic acid, polycitraconic acid, and a monovalent alkali metal cation salt thereof. This composition exhibits enhanced adhesive performance and reduces oozing and incidence of food occlusion.

公开(公告)号：EP0989839A1

公开(公告)日：2000-04-05

申请号：EP98925293.7

申请日：1998-06-05

申请人： BLOCK DRUG COMPANY INC.

发明人： WONG, Eddie ,  CLARKE, Hal, C. ,  GASMAN, Robert, C. ,  SMETANA, Alfred, J. ,  SYNODIS, Joseph

IPC分类号： A61K6/00 ,  C08F8/42 ,  C08K5/01 ,  C08L35/08

CPC分类号： A61K6/0026 ,  C08L35/08 ,  C08L33/08

摘要： A denture adhesive composition is disclosed and comprises a polymeric activator in an amount of up to about 3 percent by weight based on the total weight of the denture adhesive composition. This composition exhibits enhanced adhesive performance and reduces oozing and incidence of food occlusion. Also disclosed is a method of preparing a denture adhesive composition comprising: preparing a mixture which comprises a polymeric activator in an amount of up to about 3 percent by weight based on the total weight of the denture adhesive composition; forming a denture adhesive composition including the mixture; and recovering the denture adhesive composition. A method of making a denture adhesive composition more adhesive and less oozing is disclosed as well. This method comprises adding to the denture adhesive composition a polymeric activator in an amount of up to about 3 percent by weight based on the total weight of the denture adhesive composition.

公开(公告)号：EP0774949A1

公开(公告)日：1997-05-28

申请号：EP95928317.0

申请日：1995-08-07

申请人： BLOCK DRUG COMPANY, INC.

发明人： CLARKE, Hal, C. ,  AHN, Hyung-Kook ,  WONG, Eddie ,  GASMAN, Robert, C. ,  SMETANA, Alfred, J. ,  SYNODIS, Joseph

IPC分类号： A61K6 ,  A61K31 ,  C08F8 ,  C08F216 ,  C08F222 ,  C08L29 ,  C08L31 ,  C09J101 ,  C09J129 ,  C09J135 ,  G01N19

CPC分类号： A61K6/0026 ,  G01N19/04 ,  C08L35/08 ,  C08L1/286

摘要： A novel denture adhesive composition contains an adhesive mixture comprising sodium carboxymethyl cellulose and, either a partially neutralized sodium, magnesium, zinc mixed salt or a partially neutralized magnesium, zinc mixed salt of an alkyl vinyl ether maleic acid copolymer.