专利检索 ap:("BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM") AND inv:"GAO, Boning" 第 1 页

1.

发明授权
TISSUE FACTOR METHODS AND COMPOSITIONS FOR COAGULATION AND TUMOR TREATMENT 失效
标题翻译：方法和组织因子的组成凝血和肿瘤的治疗

公开(公告)号：EP0988056B1

公开(公告)日：2003-07-09

申请号：EP98902634.9

申请日：1998-01-20

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： THORPE, Philip, E. , KING, Steven, W. , GAO, Boning

IPC分类号： A61K47/48

CPC分类号： A61K47/6813 , A61K47/6435 , Y10S514/834 , Y10S530/827 , Y10S530/829

2.

发明公开
TISSUE FACTOR METHODS AND COMPOSITIONS FOR COAGULATION AND TUMOR TREATMENT 失效
标题翻译：方法和组织因子的组成凝血和肿瘤的治疗

公开(公告)号：EP0988056A2

公开(公告)日：2000-03-29

申请号：EP98902634.9

申请日：1998-01-20

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： THORPE, Philip, E. , KING, Steven, W. , GAO, Boning

IPC分类号： A61K47/48

CPC分类号： A61K47/6813 , A61K47/6435 , Y10S514/834 , Y10S530/827 , Y10S530/829

摘要： The invention embodies the surprising discovery that Tissue Factor (TF) compositions and variants thereof specifically localize to the blood vessels within a vascularized tumor following systemic administration. The invention therefore provides methods and compositions comprising coagulant-deficient Tissue Factor for use in effecting specific coagulation and for use in tumor treatment. The TF compositions and methods of present invention may be used alone, as TF conjugates with improved half-life, or in combination with other agents, such as conventional chemotherapeutic drugs, targeted immunotoxins, targeted coaguligands, and/or in combination with Factor VIIa(FVIIa) or FBVIIa activators.