公开(公告)号：EP0841396B2

公开(公告)日：2012-04-11

申请号：EP97307757.1

申请日：1997-10-01

申请人： GERON CORPORATION ,  The Regents of the University of Colorado

发明人： Cech, Thomas R. ,  Lingner, Joachim ,  Nakamura, Toru ,  Chapman, Karen B. ,  Morin, Cregg B. ,  Harley, Calvin B. ,  Andrews, William H.

IPC分类号： C12N15/54 ,  C12N9/12 ,  C12Q1/68 ,  C12Q1/48 ,  C12N15/11 ,  C12N15/85 ,  A01K67/027 ,  C07K16/40 ,  A61K38/45 ,  A61K31/70 ,  C12N1/21 ,  C12N1/19

CPC分类号： C12N15/113 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N9/1241 ,  C12N9/1276 ,  C12N15/1137 ,  C12N2310/15 ,  C12N2310/315 ,  C12Y207/07049 ,  Y10S530/827 ,  Y10S530/828

公开(公告)号：EP1783139B1

公开(公告)日：2009-07-15

申请号：EP06117664.0

申请日：1997-10-01

申请人： GERON CORPORATION

发明人： Cech, Thomas R ,  Lingner, Joachim ,  Nakamura, Toru ,  Chapman, Karen B. ,  Morin, Gregg, B ,  Harley, Calvin B. ,  Andrews, William H.

IPC分类号： C07K4/12

CPC分类号： C12N15/113 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N9/1241 ,  C12N9/1276 ,  C12N15/1137 ,  C12N2310/15 ,  C12N2310/315 ,  C12Y207/07049 ,  Y10S530/827 ,  Y10S530/828

公开(公告)号：EP1783139A3

公开(公告)日：2007-05-23

申请号：EP06117664.0

申请日：1997-10-01

申请人： GERON CORPORATION

发明人： Cech, Thomas R ,  Lingner, Joachim ,  Nakamura, Toru ,  Chapman, Karen B. ,  Morin, Gregg, B ,  Harley, Calvin B. ,  Andrews, William H.

IPC分类号： C07K4/12

CPC分类号： C12N15/113 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N9/1241 ,  C12N9/1276 ,  C12N15/1137 ,  C12N2310/15 ,  C12N2310/315 ,  C12Y207/07049 ,  Y10S530/827 ,  Y10S530/828

摘要： The invention provides immunogenic peptides of human telomerase reverse transcriptase (hTRT). The peptides of the invention are useful for diagnosis, prognosis and treatment of human diseases, for changing the proliferative capacity of cells and organisms, and for identification and screening of compounds and treatments useful for treatment of disease such as cancers.

公开(公告)号：EP1337546A2

公开(公告)日：2003-08-27

申请号：EP01979547.5

申请日：2001-10-08

申请人： New York Blood Center, Inc.

发明人： BELYAVSKY, Alexander ,  SHMELKOV, Sergey ,  VISSER, Jan

IPC分类号： C07H21/04 ,  C07K14/435 ,  C07K14/705 ,  C07K16/28 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/531 ,  G01N33/543 ,  G01N33/554 ,  G01N33/567 ,  G01N33/577

CPC分类号： C07K14/70596 ,  Y10S530/827

摘要： The present invention provides an isolated nucleic acid sequence encoding KIAA0918, and an isolated nucleic acid sequence that hybridizes under high stringency conditions to a second nucleic acid that is complementary to a nucleic acid sequence encoding KIAA0918. The present invention also discloses a purified KIAA0918 protein, and a purified protein encoded by a nucleic acid sequence that hybridizes under high stringency conditions to a second nucleic acid sequence that is complementary to a nucleic acid sequence encoding KIIAA0918. Also provided is a method of making KIAA0918 protein. The present invention further discloses an antibody specific for KIAA0918, and a method for producing an antibody specific for KIAA0918 protein. Additionally, the present invention is directed to a vector comprising a nucleic acid sequence encoding KIAA0918, and a host cell transformed with a vector comprising a nucleic acid sequence encoding KIAA0918. Also provided is a method for detecting the presence of hematopoietic stem cells in a heterogeneous cell suspension that may contain hematopoietic stem cells, as well as a method for isolating hematopoietic stem cells from a heterogeneous cell suspension that may contain hematopoietic stem cells. Finally, the present invention discloses a method for assessing gene expression in a tissue sample.

公开(公告)号：EP0841396B1

公开(公告)日：2003-07-16

申请号：EP97307757.1

申请日：1997-10-01

申请人： Geron Corporation ,  University Technology Corporation

发明人： Cech, Thomas R. ,  Lingner, Joachim ,  Nakamura, Toru ,  Chapman, Karen B. ,  Morin, Cregg B. ,  Harley, Calvin B. ,  Andrews, William H.

IPC分类号： C12N15/54 ,  C12N9/12 ,  C12Q1/68 ,  C12Q1/48 ,  C12N15/11 ,  C12N15/85 ,  A01K67/027 ,  C07K16/40 ,  A61K38/45 ,  A61K31/70 ,  C12N1/21 ,  C12N1/19

CPC分类号： C12N15/113 ,  A01K2217/05 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  C07K2319/00 ,  C12N9/1241 ,  C12N9/1276 ,  C12N15/1137 ,  C12N2310/15 ,  C12N2310/315 ,  C12Y207/07049 ,  Y10S530/827 ,  Y10S530/828

公开(公告)号：EP0559064B1

公开(公告)日：2001-05-23

申请号：EP93102848.4

申请日：1993-02-24

申请人： Aventis Research & Technologies GmbH & Co. KG

发明人： Müllner, Stefan, Dr. ,  Müller, Günter, Dr.

IPC分类号： C12N9/16 ,  C12N9/18 ,  C07J9/00 ,  C07K1/00

CPC分类号： C07J41/0088 ,  C07K1/32 ,  C12N9/16 ,  C12N9/18 ,  Y10S530/813 ,  Y10S530/827

公开(公告)号：EP1026504A1

公开(公告)日：2000-08-09

申请号：EP00101326.7

申请日：2000-01-22

申请人： Toyo Boseki Kabushiki Kaisha

发明人： Soya, Yoshihiro, C/O Tsuruga Institute of Biotechn ,  Nishii, Shigeaki, C/O Tsuruga Institute of Biotech ,  Matsui, Kazuhiro, C/O Tsuruga Institute of Biotech ,  Ishibashi, Takuya, C/O Tsuruga Institute of Biotec ,  Kawamura, Yoshihisa, C/O Tsuruga Institute of Bio.

IPC分类号： G01N33/53 ,  G01N33/74 ,  G01N33/566

CPC分类号： G01N33/743 ,  G01N33/53 ,  G01N33/54306 ,  G01N2333/723 ,  Y10S530/812 ,  Y10S530/816 ,  Y10S530/827

摘要： The present invention provides a method capable of simultaneous processing of plural test samples for the receptor binding property of a chemical substance, which does not require immobilization of the receptor or a special device, and a reagent to be used for this method. That is a method for assaying the receptor binding property of an assay target substance is provided, the method comprising the steps of (a) competitively reacting a known concentration of a ligand and the assay target substance with a known concentration of the receptor in a solution, (b) measuring, without physically removing the ligand bound with the receptor prior to the assay, the amount of a free ligand in the solution using one or more antibodies against the ligand, and (c) determining the receptor binding property of the assay target substance using the amount of the free ligand as an index.

摘要翻译： 本发明提供一种能够同时处理多个测试样品用于不需要固定受体或特殊装置的化学物质的受体结合特性的试剂和用于该方法的试剂。 这是一种用于测定测定目标物质的受体结合性质的方法，该方法包括以下步骤：（a）使已知浓度的配体和测定目标物质与已知浓度的受体在溶液中竞争性地反应 ，（b）在测定前不用物理去除与受体结合的配体，测量溶液中使用一种或多种针对配体的抗体的游离配体的量，和（c）测定测定的受体结合性质 使用游离配体的量作为指标的目标物质。

公开(公告)号：EP0986646A1

公开(公告)日：2000-03-22

申请号：EP98924880.2

申请日：1998-05-21

申请人： INCYTE PHARMACEUTICALS, INC.

发明人： BANDMAN, Olga ,  CORLEY, Neil, C. ,  LAL, Preeti ,  SHAH, Purvi

IPC分类号： C12N15/52 ,  C12N9/00 ,  C12Q1/68 ,  C12N15/11 ,  A61K38/53 ,  C07K16/40

CPC分类号： C12N9/93 ,  A61K38/00 ,  Y10S530/827

摘要： The present invention provides a human ubiquitin conjugation system protein (UCSP) and polynucleotides which encode UCSP. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of UCSP.

公开(公告)号：EP0960117A1

公开(公告)日：1999-12-01

申请号：EP97940685.0

申请日：1997-08-27

申请人： THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE

发明人： NATHANS, Jeremy ,  SMALLWOOD, Philip, M.

IPC分类号： C12N15 ,  A61K31 ,  A61K38 ,  A61K39 ,  A61K45 ,  A61K48 ,  A61P15 ,  A61P25 ,  A61P27 ,  A61P31 ,  A61P35 ,  A61P37 ,  A61P43 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12P21 ,  C12Q1

CPC分类号： C07K14/50 ,  A61K38/00 ,  Y10S530/806 ,  Y10S530/81 ,  Y10S530/811 ,  Y10S530/812 ,  Y10S530/813 ,  Y10S530/814 ,  Y10S530/815 ,  Y10S530/827

摘要： The invention provides fibroblast growth factor homologous factor (FHF) polypeptides and nucleic acid molecules that encode them. Also included in the invention are diagnostic and therapeutic methods using FHF polypeptides and nucleic acids.

公开(公告)号：EP0488061B1

公开(公告)日：1998-11-04

申请号：EP91119894.3

申请日：1991-11-21

申请人： CENTER FOR BLOOD RESEARCH, INC.

发明人： Diamond, Michael S. ,  Staunton, Donald E. ,  Springer, Timothy A.

IPC分类号： C07K14/705 ,  A61K38/17 ,  A61K39/395 ,  C12P21/08

CPC分类号： C07K14/70525 ,  A61K38/00 ,  C07K16/2821 ,  Y10S530/808 ,  Y10S530/827 ,  Y10S530/868