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公开(公告)号：EP1802636B1
公开(公告)日：2013-03-27
申请号：EP05805652.4
申请日：2005-10-05
发明人： BREITFELDER, Steffen , MAIER, Udo , BRANDL, Trixi , HOENKE, Christoph , GRAUERT, Matthias , PAUTSCH, Alexander , HOFFMANN, Matthias , KALKBRENNER, Frank , JOERGENSEN, Anne , SCHAENZLE, Gerhard , PETERS, Stefan , BÜTTNER, Frank , BAUER, Eckhart
IPC分类号： C07D513/04 , C07D277/84 , A61K31/428 , A61K31/429 , A61P35/00
CPC分类号： C07D513/04 , C07D277/84
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公开(公告)号：EP1802636A1
公开(公告)日：2007-07-04
申请号：EP05805652.4
申请日：2005-10-05
发明人： BREITFELDER, Steffen , MAIER, Udo , BRANDL, Trixi , HOENKE, Christoph , GRAUERT, Matthias , PAUTSCH, Alexander , HOFFMANN, Matthias , KALKBRENNER, Frank , JOERGENSEN, Anne , SCHAENZLE, Gerhard , PETERS, Stefan , BÜTTNER, Frank , BAUER, Eckhart
IPC分类号： C07D513/04 , C07D277/84 , A61K31/428 , A61K31/429 , A61P35/00
CPC分类号： C07D513/04 , C07D277/84
摘要： The invention relates to the novel compounds of formula (1), which, due to their pharmaceutical effect as PI3 kinase modulators, are suitable for use in the therapy and treatment of inflammatory or allergic diseases. Examples of these diseases are inflammatory and allergic respiratory diseases, inflammatory diseases of the gastro-intestinal system and of the locomotor apparatus, inflammatory and allergic skin diseases, inflammatory ophthalmic diseases, diseases of the nasal mucosa, inflammatory or allergic autoimmune reactive conditions, or renal inflammations.
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3.发明公开DETECTION OF NO BY USING GUANYLYL CYCLASE AND CGMP PRODUCTION AS A READOUT SYSTEM 有权证明没有使用鸟苷酸环化酶和cGMP生产为读出系统
公开(公告)号：EP1689880A1
公开(公告)日：2006-08-16
申请号：EP04819231.4
申请日：2004-11-25
发明人： BÜTTNER, Frank
CPC分类号： A61K31/198 , C12Q1/26 , C12Q1/32
摘要： A method for measuring nitric oxide synthase activity, characterized in the method comprises; (a) providing a solution comprising a nitric oxide synthase and a suitable substrate under conditions which allow synthesis of nitric oxide; (b) adding guanylyl cyclase and GTP under conditions which allow synthesis of cGMP; (c) measuring cGMP.
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4.发明授权DETECTION OF NO BY USING GUANYLYL CYCLASE AND CGMP PRODUCTION AS A READOUT SYSTEM 有权证明没有使用鸟苷酸环化酶和cGMP生产为读出系统
公开(公告)号：EP1689880B1
公开(公告)日：2009-04-22
申请号：EP04819231.4
申请日：2004-11-25
发明人： BÜTTNER, Frank
CPC分类号： A61K31/198 , C12Q1/26 , C12Q1/32
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