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公开(公告)号：EP3063169B1
公开(公告)日：2018-10-10
申请号：EP14793493.9
申请日：2014-10-27
IPC分类号： C07K14/435
CPC分类号： G01N33/5432 , C08G18/289 , C12N9/0006 , C12N11/08 , C12Q1/006 , C12Q1/32 , C12Q1/54 , G01N33/48721 , G01N33/5038 , G01N33/54346
摘要： The present invention relates to a test element for the detection of an analyte comprising an enzyme, wherein the enzyme is incorporated in a nanocapsule.
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公开(公告)号：EP3380457A1
公开(公告)日：2018-10-03
申请号：EP16863619.9
申请日：2016-11-09
IPC分类号： C07D257/04 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , G01N21/31 , C12Q1/34 , C12Q1/32
CPC分类号： C07D257/04 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D417/04 , C12Q1/32 , G01N21/78 , G01N2333/90611 , G01N2333/90616
摘要： A class of compounds of monosulfonic phenyltetrazole, with the structure of 2-(R1 phenyl)-5 (2-sulfonic phenyl)-2H-tetrazole. The 2-sulfonic phenyl tetrazolium salt of this invention has advantages of low toxicity, short synthetic route, easy control of purity and quality. As the 2-sulfonic phenyl tetrazolium salts has almost no absorption at 450 nm where the reduzate has greater absorption, spectrophotometry can simply and rapidly determine the activity of glutamate dehydrogenase, or the content of NADH/NADPH.
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公开(公告)号：EP3368896A1
公开(公告)日：2018-09-05
申请号：EP16797688.5
申请日：2016-10-30
申请人： FMC Corporation
CPC分类号： C12Q1/32 , A01N25/00 , A01N43/36 , A01N43/40 , A01N43/56 , C12N9/001 , C12Y103/05002 , G01N2333/90206
摘要： This invention relates to the production of herbicidal compounds and compositions comprising the same which inhibit dihydroorotate dehydrogenase.
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公开(公告)号：EP2773955B1
公开(公告)日：2018-07-18
申请号：EP12787307.3
申请日：2012-11-05
申请人： inRegen
CPC分类号： G01N33/5082 , C12N5/0686 , C12N2500/02 , C12N2503/02 , C12Q1/32 , G01N33/4833 , G01N33/5008 , G01N33/5014 , G01N33/5023 , G01N33/5044 , G01N33/5076 , G01N2500/02 , G01N2500/10 , G01N2800/347
摘要： The present invention concerns bioactive renal cell populations, in particular a B2 cell population comprising an enriched population of tubular cells and wherein the renal cell population is depleted of a B1 cell population, renal cell constructs, and methods of screening test agents using the bioactive renal cell populations.
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公开(公告)号：EP3327133A1
公开(公告)日：2018-05-30
申请号：EP18151469.6
申请日：2013-12-19
发明人： Tonks, Simon
IPC分类号： C12Q1/54
CPC分类号： C12Q1/006 , C12Q1/26 , C12Q1/32 , G01N27/12 , G01N27/226 , G01N27/3272
摘要： The present disclosure relates to methods and devices for providing accurate measurement of a property of a sample. The method comprises obtaining a plurality of independent measurements of the property. The plurality of values of the property of the sample obtained by the plurality of independent measurements is compared to determine whether one or more of the values is an outlier.
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公开(公告)号：EP3122893A4
公开(公告)日：2017-12-13
申请号：EP15768552
申请日：2015-03-27
CPC分类号： C12Q1/32 , G01N33/5091 , G01N2500/10 , G01N2800/7038
摘要： The present disclosure provides, among other things, methods and compositions for diagnosing and treating stress-induced injuries, hypoxia in particular. The present invention is based, in part, on the novel discovery that a metabolite, L-2-hydroxyglutarate, and certain enzymes and substrates regulating its metabolism, mediate stress-induced cellular mechanisms. In some embodiments, provided methods and compositions are used to diagnose and treat diseases with hypoxia-induced injuries. In some embodiments, provided methods and compositions are used to modulate cell pluripotency or differentiation in vivo or in vitro.
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公开(公告)号：EP2695939B1
公开(公告)日：2017-11-01
申请号：EP12765279.0
申请日：2012-03-30
申请人： Nipro Corporation
CPC分类号： C12N9/0006 , C12P21/02 , C12Q1/32 , C12Q1/54 , C12Y101/01047
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8.发明公开FLAVIN-BINDING GLUCOSE DEHYDROGENASE HAVING IMPROVED SPECIFIC ACTIVITY 审中-公开FLAVINBINDENDE GLUCOSEDEHYDROGENASE MIT VERBESSERTER SPEZIFISCHERAKTIVITÄT
公开(公告)号：EP3112461A4
公开(公告)日：2017-08-09
申请号：EP15754649
申请日：2015-02-13
申请人： KIKKOMAN CORP
发明人： ARAKI YASUKO
IPC分类号： C12N15/09 , C12M1/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/04 , C12Q1/32 , C12Q1/54
CPC分类号： C12Y101/9901 , C12N9/0006 , C12Q1/32 , C12Q1/54
摘要： The present invention provides a flavin-binding glucose dehydrogenase that has one or more amino acid substitutions at positions corresponding to position 88 or position 554 in the amino acid sequence set forth in SEQ ID NO: 1.
摘要翻译： 本发明提供了黄素结合葡萄糖脱氢酶，其在对应于SEQ ID NO：1所示的氨基酸序列中的位置88或位置554的位置具有一个或多个氨基酸取代。
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公开(公告)号：EP3156791A1
公开(公告)日：2017-04-19
申请号：EP16194045.7
申请日：2016-10-14
发明人： KATSUKI, Koji , KANEDA, Hisashi , SHIMAZAKI, Junko
IPC分类号： G01N27/327 , C12Q1/00
CPC分类号： C12Q1/006 , C12Q1/001 , C12Q1/25 , C12Q1/32 , C23C14/0605 , C23C14/205 , C23C14/24 , C23C14/34 , C23C14/58 , C23C16/06 , C23C16/44 , C23C16/56 , C23C28/00 , G01N27/3271 , G01N27/3272
摘要： An enzyme electrode including an electrode, and a detection layer which contacts the electrode and contains a crosslinking agent, an electrically conductive macromolecule and an enzyme transferring and receiving electrons to and from the electrode and does not contain an electron transfer subunit.
摘要翻译： 包括电极的酶电极和与电极接触并含有交联剂的检测层，导电性高分子和向电极转移电子并从电极接收电子并且不含电子转移子单元的酶。
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10.发明授权DIHYDROOROTATE DEHYDROGENASE AS ANTIFUNGAL DRUG TARGET 有权DIHYDROOROTAT-DEHYDROGENASE ALS ANTIPILZMITTELZIEL
公开(公告)号：EP2283151B1
公开(公告)日：2017-03-08
申请号：EP09738409.3
申请日：2009-05-01
申请人： F2G Limited
发明人： OLIVER, Jason, David , THAIN, John, Leslie , BROMLEY, Michael, John , SIBLEY, Graham, Edward, Morris , BIRCH, Michael
IPC分类号： C12Q1/32 , C12N9/02 , C07D239/95 , A61P31/10
CPC分类号： C12Q1/32 , C07D239/95 , C12N9/001 , C12Y103/05002 , G01N2333/90206 , G01N2500/02
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