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公开(公告)号：EP2018386A1
公开(公告)日：2009-01-28
申请号：EP07727386.0
申请日：2007-03-27
发明人： MAIER, Udo , GRAUERT, Matthias , HOFFMANN, Matthias , HOENKE, Christoph , JOERGENSEN, Anne, T. , PAUTSCH, Alexander , BRANDL, Trixi , BREITFELDER, Steffen , SCHEUERER, Stefan , ERB, Klaus , PIEPER, Michael , PRAGST, Ingo
IPC分类号： C07D513/04 , A61K31/429 , A61P29/00
CPC分类号： C07D513/04
摘要： The present invention relates to compounds of the general formula (I) where the R1, R2, Ra and Rb radicals are each as defined in the claims and the description, to their tautomers, racemates, enantiomers, diastereomers and mixtures thereof, and where appropriate to their pharmacologically safe acid addition salts, solvates and hydrates, and to processes for preparing these thiazolyldihydroindazoles and to their use as medicaments.
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2.发明公开THIAZOLYL-DIHYDRO-CYCLOPENTAPYRAZOLE ZUR VERWENDUNG ALS PI3-KINASE-INHIBIT0REN 审中-公开噻唑二氢 - 环戊FOR USE AS PI3激酶INHIBIT0REN
公开(公告)号：EP2007382A1
公开(公告)日：2008-12-31
申请号：EP07727387.8
申请日：2007-03-27
发明人： BREITFELDER, Steffen , MAIER, Udo , HOENKE, Christoph , JOERGENSEN, Anne T. , PAUTSCH, Alexander , BRANDL, Trixi , GRAUERT, Matthias , HOFFMANN, Matthias , SCHEUERER, Stefan , ERB, Klaus , PIEPER, Michael , PRAGST, Ingo
IPC分类号： A61K31/429 , C07D513/04 , A61P35/00 , A61P11/00
CPC分类号： C07D513/04
摘要： The present invention relates to compounds of the general formula (I), where the radicals R1, R2, Ra and Rb have the meanings specified in the claims and the description, their tautomers, racemates, enantiomers, diastereomers and their mixtures, and optionally their pharmacologically acceptable acid addition salts, solvates and hydrates, and to processes for the preparation of these thiazolyldihydrocyclopentapyrazoles and their use as medicaments.
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公开(公告)号：EP2018385B1
公开(公告)日：2013-05-15
申请号：EP07727385.2
申请日：2007-03-27
发明人： BRANDL, Trixi , MAIER, Udo , HOFFMANN, Matthias , SCHEUERER, Stefan , JOERGENSEN, Anne, T. , PAUTSCH, Alexander , BREITFELDER, Steffen , GRAUERT, Matthias , HOENKE, Christoph , ERB, Klaus , PIEPER, Michael , PRAGST, Ingo
IPC分类号： C07D513/04 , A61K31/429 , A61P29/00
CPC分类号： C07D513/04
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公开(公告)号：EP2018387A1
公开(公告)日：2009-01-28
申请号：EP07727389.4
申请日：2007-03-27
发明人： GRAUERT, Matthias , MAIER, Udo , HOFFMANN, Matthias , SCHEUERER, Stefan , JOERGENSEN, Anne T. , PAUTSCH, Alexander , BRANDL, Trixi , HOENKE, Christoph , BREITFELDER, Steffen , ERB, Klaus , PIEPER, Michael , PRAGST, Ingo
IPC分类号： C07D513/04 , A61K31/429 , A61P29/00
CPC分类号： C07D513/04
摘要： The present invention relates to novel thiazolyldihydroindazoles of the general formula (I) where the R1, R2 and R3 radicals are each as defined in the claims and the description, to their tautomers, racemates, enantiomers, diastereomers and mixtures thereof, and where appropriate to their pharmacologically safe acid addition salts, solvates and hydrates, and to processes for preparing these thiazolyldihydroindazoles and to their use as medicaments.
摘要翻译： 本发明涉及通式（I）的新噻唑基二氢吲唑类化合物，其中R 1，R 2和R 3基团各自如权利要求书和说明书中所定义，涉及它们的互变异构体，外消旋体，对映体，非对映体和混合物， 其药理学上安全的酸加成盐，溶剂化物和水合物，以及制备这些噻唑基二氢吲哚的方法及其作为药物的用途。
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公开(公告)号：EP2018385A1
公开(公告)日：2009-01-28
申请号：EP07727385.2
申请日：2007-03-27
发明人： BRANDL, Trixi , MAIER, Udo , HOFFMANN, Matthias , SCHEUERER, Stefan , JOERGENSEN, Anne, T. , PAUTSCH, Alexander , BREITFELDER, Steffen , GRAUERT, Matthias , HOENKE, Christoph , ERB, Klaus , PIEPER, Michael , PRAGST, Ingo
IPC分类号： C07D513/04 , A61K31/429 , A61P29/00
CPC分类号： C07D513/04
摘要： The invention relates to novel thiazolyl-dihydroquinazolines of general formula (I), wherein the groups R1 to R4 are defined as in the claims and in the description, and to the isomers thereof. The invention also relates to methods for producing said thiazolyl-dihydroindazoles and to their use as drugs.
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公开(公告)号：EP2007772A1
公开(公告)日：2008-12-31
申请号：EP07727388.6
申请日：2007-03-27
发明人： BRANDL, Trixi , MAIER, Udo , HOENKE, Christoph , JOERGENSEN, Anne T. , PAUTSCH, Alexander , BREITFELDER, Steffen , GRAUERT, Matthias , HOFFMANN, Matthias , SCHEUERER, Stefan , ERB, Klaus , PIEPER, Michael , PRAGST, Ingo
IPC分类号： C07D513/04 , A61K31/429 , A61P29/00 , A61P37/00
CPC分类号： C07D513/04
摘要： The invention relates to compounds of general formula (I), wherein the groups A, R1, R2, Ra and Rb are defined as in the claims and the description, and to the tautomers, racemates, enantiomers, diastereomers and mixtures thereof, optionally the pharmacologically acceptable acid addition salts, solvates and hydrates thereof. The invention also relates to methods for producing said thiazolyl-dihydroquinazolines and to their use as drugs.
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