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公开(公告)号：EP1915155A1
公开(公告)日：2008-04-30
申请号：EP06777805.0
申请日：2006-07-17
发明人： MAIER, Udo , KALKBRENNER, Frank , BREITFELDER, Steffen , BUETTNER, Frank , GRAUERT, Matthias , HOFFMANN, Matthias
IPC分类号： A61K31/519 , A61P11/08
CPC分类号： A61K45/06 , A61K31/519 , A61K2300/00
摘要： The present invention relates to the use of dihydropteridinones of formula (1), wherein the groups X, R1 , R2, R3, R4, R5, R6 and R7 have the meanings given in the claims and specification, for the preparation of a medicament for the treatment of respiratory diseases.
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公开(公告)号：EP1799690B1
公开(公告)日：2008-04-16
申请号：EP05792037.3
申请日：2005-10-05
发明人： BETZEMEIER, Bodo , BRANDL, Trixi , BREITFELDER, Steffen , BRUECKNER, Ralph , GERSTBERGER, Thomas , GMACHL, Michael , GRAUERT, Matthias , HILBERG, Frank , HOENKE, Christoph , HOFFMANN, Matthias , IMPAGNATIELLO, Maria , KESSLER, Dirk , KLEIN, Christian , KRIST, Bernd , MAIER, Udo , MCCONNELL, Darryl , REITHER, Charlotte , SCHEUERER,Stefan , SCHOOP, Andreas , SCHWEIFER, Norbert , SIMON, Oliver , STEEGMAIER, Martin , STEURER, Steffen , WAIZENEGGER, Irene , WEYER-CZERNILOFSKY, Ulrike , ZOEPHEL, Andreas
IPC分类号： C07D513/04 , C07D417/06 , C07D277/82 , A61K31/429 , A61P35/00
CPC分类号： C07D513/04 , C07D277/82 , C07D277/84 , C07D417/06
摘要： The invention relates to the compounds of general formula (1), wherein R1 to R3 are defined as in claim 1, which are suitable for use in the treatment of diseases that are characterized by excessive or abnormal cell proliferation. The invention also relates to the use of said compounds for producing a drug having the aforementioned properties.
摘要翻译： 本发明涉及通式（1）的化合物，其中R 1至R 3如权利要求1中所定义，其适用于治疗以过度或异常细胞增殖为特征的疾病。 本发明还涉及所述化合物用于制备具有上述性质的药物的用途。
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公开(公告)号：EP1799690A1
公开(公告)日：2007-06-27
申请号：EP05792037.3
申请日：2005-10-05
发明人： BETZEMEIER, Bodo , BRANDL, Trixi , BREITFELDER, Steffen , BRUECKNER, Ralph , GERSTBERGER, Thomas , GMACHL, Michael , GRAUERT, Matthias , HILBERG, Frank , HOENKE, Christoph , HOFFMANN, Matthias , IMPAGNATIELLO, Maria , KESSLER, Dirk , KLEIN, Christian , KRIST, Bernd , MAIER, Udo , MCCONNELL, Darryl , REITHER, Charlotte , SCHEUERER,Stefan , SCHOOP, Andreas , SCHWEIFER, Norbert , SIMON, Oliver , STEEGMAIER, Martin , STEURER, Steffen , WAIZENEGGER, Irene , WEYER-CZERNILOFSKY, Ulrike , ZOEPHEL, Andreas
IPC分类号： C07D513/04 , C07D417/06 , C07D277/82 , A61K31/429 , A61P35/00
CPC分类号： C07D513/04 , C07D277/82 , C07D277/84 , C07D417/06
摘要： The invention relates to the compounds of general formula (1), wherein R1 to R3 are defined as in claim 1, which are suitable for use in the treatment of diseases that are characterized by excessive or abnormal cell proliferation. The invention also relates to the use of said compounds for producing a drug having the aforementioned properties.
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公开(公告)号：EP2114945B1
公开(公告)日：2010-10-20
申请号：EP08708304.4
申请日：2008-01-28
发明人： GIOVANNINI, Riccardo , FRATTINI, Sara , BRANDL, Trixi , BREITFELDER, Steffen , CEREDA, Enzo , GRAUERT, Matthias , HOFFMANN, Matthias , JOERGENSEN, Anne T. , MAIER, Udo , PAUTSCH, Alexander , QUAI, Monica , SCHEUERER, Stefan
IPC分类号： C07D487/04 , A61K31/519 , A61P29/00 , A61P11/00
CPC分类号： C07D487/04
摘要： New compounds of Formula (1) are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.
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公开(公告)号：EP2018386A1
公开(公告)日：2009-01-28
申请号：EP07727386.0
申请日：2007-03-27
发明人： MAIER, Udo , GRAUERT, Matthias , HOFFMANN, Matthias , HOENKE, Christoph , JOERGENSEN, Anne, T. , PAUTSCH, Alexander , BRANDL, Trixi , BREITFELDER, Steffen , SCHEUERER, Stefan , ERB, Klaus , PIEPER, Michael , PRAGST, Ingo
IPC分类号： C07D513/04 , A61K31/429 , A61P29/00
CPC分类号： C07D513/04
摘要： The present invention relates to compounds of the general formula (I) where the R1, R2, Ra and Rb radicals are each as defined in the claims and the description, to their tautomers, racemates, enantiomers, diastereomers and mixtures thereof, and where appropriate to their pharmacologically safe acid addition salts, solvates and hydrates, and to processes for preparing these thiazolyldihydroindazoles and to their use as medicaments.
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6.发明公开THIAZOLYL-DIHYDRO-CYCLOPENTAPYRAZOLE ZUR VERWENDUNG ALS PI3-KINASE-INHIBIT0REN 审中-公开噻唑二氢 - 环戊FOR USE AS PI3激酶INHIBIT0REN
公开(公告)号：EP2007382A1
公开(公告)日：2008-12-31
申请号：EP07727387.8
申请日：2007-03-27
发明人： BREITFELDER, Steffen , MAIER, Udo , HOENKE, Christoph , JOERGENSEN, Anne T. , PAUTSCH, Alexander , BRANDL, Trixi , GRAUERT, Matthias , HOFFMANN, Matthias , SCHEUERER, Stefan , ERB, Klaus , PIEPER, Michael , PRAGST, Ingo
IPC分类号： A61K31/429 , C07D513/04 , A61P35/00 , A61P11/00
CPC分类号： C07D513/04
摘要： The present invention relates to compounds of the general formula (I), where the radicals R1, R2, Ra and Rb have the meanings specified in the claims and the description, their tautomers, racemates, enantiomers, diastereomers and their mixtures, and optionally their pharmacologically acceptable acid addition salts, solvates and hydrates, and to processes for the preparation of these thiazolyldihydrocyclopentapyrazoles and their use as medicaments.
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7.发明公开
公开(公告)号：EP1747208A1
公开(公告)日：2007-01-31
申请号：EP05740022.8
申请日：2005-05-10
发明人： BOUYSSOU, Thierry , SCHNAPP, Andreas , LUSTENBERGER, Philipp , RUDOLF, Klaus , PIEPER, Michael, P. , GRAUERT, Matthias , BREITFELDER, Steffen , SPECK, Georg
IPC分类号： C07D265/36 , C07D471/08 , A61K31/538 , A61P11/00
CPC分类号： C07D265/36 , C07D471/08
摘要： The invention relates to the compounds of general formula (1), wherein the groups n, A, B, D, L, R1, R2, R3 and R4 are defined as in the claims and in the description, and to methods for producing the same. The invention also relates to the use of these compounds as drugs, especially as drugs for use in the treatment of respiratory diseases.
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公开(公告)号：EP1802636B1
公开(公告)日：2013-03-27
申请号：EP05805652.4
申请日：2005-10-05
发明人： BREITFELDER, Steffen , MAIER, Udo , BRANDL, Trixi , HOENKE, Christoph , GRAUERT, Matthias , PAUTSCH, Alexander , HOFFMANN, Matthias , KALKBRENNER, Frank , JOERGENSEN, Anne , SCHAENZLE, Gerhard , PETERS, Stefan , BÜTTNER, Frank , BAUER, Eckhart
IPC分类号： C07D513/04 , C07D277/84 , A61K31/428 , A61K31/429 , A61P35/00
CPC分类号： C07D513/04 , C07D277/84
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公开(公告)号：EP2114945A1
公开(公告)日：2009-11-11
申请号：EP08708304.4
申请日：2008-01-28
发明人： GIOVANNINI, Riccardo , FRATTINI, Sara , BRANDL, Trixi , BREITFELDER, Steffen , CEREDA, Enzo , GRAUERT, Matthias , HOFFMANN, Matthias , JOERGENSEN, Anne T. , MAIER, Udo , PAUTSCH, Alexander , QUAI, Monica , SCHEUERER, Stefan
IPC分类号： C07D487/04 , A61K31/519 , A61P29/00 , A61P11/00
CPC分类号： C07D487/04
摘要： New compounds of Formula (1) are provided which by virtue of their pharmaceutical activity as PI3-kinase modulators may be used in the therapeutic field for the treatment of inflammatory or allergic diseases. Examples of these include inflammatory and allergic respiratory complaints, inflammatory diseases of the gastro-intestinal tract and motor apparatus, inflammatory and allergic skin diseases, inflammatory eye diseases, diseases of the nasal mucosa, inflammatory or allergic conditions involving autoimmune reactions or inflammations of the kidney.
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公开(公告)号：EP1802636A1
公开(公告)日：2007-07-04
申请号：EP05805652.4
申请日：2005-10-05
发明人： BREITFELDER, Steffen , MAIER, Udo , BRANDL, Trixi , HOENKE, Christoph , GRAUERT, Matthias , PAUTSCH, Alexander , HOFFMANN, Matthias , KALKBRENNER, Frank , JOERGENSEN, Anne , SCHAENZLE, Gerhard , PETERS, Stefan , BÜTTNER, Frank , BAUER, Eckhart
IPC分类号： C07D513/04 , C07D277/84 , A61K31/428 , A61K31/429 , A61P35/00
CPC分类号： C07D513/04 , C07D277/84
摘要： The invention relates to the novel compounds of formula (1), which, due to their pharmaceutical effect as PI3 kinase modulators, are suitable for use in the therapy and treatment of inflammatory or allergic diseases. Examples of these diseases are inflammatory and allergic respiratory diseases, inflammatory diseases of the gastro-intestinal system and of the locomotor apparatus, inflammatory and allergic skin diseases, inflammatory ophthalmic diseases, diseases of the nasal mucosa, inflammatory or allergic autoimmune reactive conditions, or renal inflammations.
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