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1.发明公开
公开(公告)号：EP1996545A1
公开(公告)日：2008-12-03
申请号：EP07758126.2
申请日：2007-03-08
发明人： DE LOMBAERT, Stephane , ELDRUP, Anne, Bettina , KOWALSKI, Jennifer, A. , MUGGE, Ingo, Andreas , SOLEYMANZADEH, Fariba , SWINAMER, Alan, David , TAYLOR, Steven, John
IPC分类号： C07D207/12 , C07D211/22 , C07D211/46 , C07D211/58 , C07D211/62 , C07D295/20 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , A61K31/4545 , A61P9/00
CPC分类号： C07D295/215 , C07D207/12 , C07D211/22 , C07D211/46 , C07D211/58 , C07D211/62 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12
摘要： Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same.
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公开(公告)号：EP2152674A1
公开(公告)日：2010-02-17
申请号：EP08755478.8
申请日：2008-05-15
发明人： ABEYWARDANE, Asitha , COOK, Brian, Nicholas , DE LOMBAERT, Stephane , EMMANUEL, Michel, Jose , GUO, Xin , KIM, Jin, Mi , HAO, Ming-Hong , LO, Ho, Yin , MAN, Chuk, Chui , MORWICK, Tina , NEMOTO, Peter, Allen , QIAN, Kevin, Chungeng , TAKAHASHI, Hidenori , TAYLOR, Steven, John
IPC分类号： C07D235/26 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , A61K31/4184 , A61P11/06
CPC分类号： C07D409/06 , C07D235/26 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
摘要： Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.
摘要翻译： 公开了用于治疗涉及糜蛋白酶的各种疾病和病症的小分子抑制剂。
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3.发明公开N-SUBSTITUTED PYRIDINONE OR PYRIMIDINONE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS 审中-公开可溶性EPOXIDHYDROLASEINHIBITOREN合适的N-取代的吡啶酮嘧啶
公开(公告)号：EP1934182A1
公开(公告)日：2008-06-25
申请号：EP06816368.2
申请日：2006-10-04
IPC分类号： C07D213/82 , C07D413/06 , A61K31/4412 , A61K31/443
CPC分类号： C07D213/82 , C07D413/06
摘要： Disclosed are compounds of the formula (I) with the definitions of A1 D, Q, W, X, Y and Z as indicated in the description, which are active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same. (I)
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公开(公告)号：EP2152674B1
公开(公告)日：2011-08-03
申请号：EP08755478.8
申请日：2008-05-15
发明人： ABEYWARDANE, Asitha , COOK, Brian, Nicholas , DE LOMBAERT, Stephane , EMMANUEL, Michel, Jose , GUO, Xin , KIM, Jin, Mi , HAO, Ming-Hong , LO, Ho, Yin , MAN, Chuk, Chui , MORWICK, Tina , NEMOTO, Peter, Allen , QIAN, Kevin, Chungeng , TAKAHASHI, Hidenori , TAYLOR, Steven, John
IPC分类号： C07D235/26 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , A61K31/4184 , A61P11/06
CPC分类号： C07D409/06 , C07D235/26 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/06 , C07D417/06 , C07D417/14 , C07D471/04
摘要： Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase.
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5.发明公开SUBSTITUTED PYRIDINEAMIDE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS 审中-公开取代的吡啶酰胺类化合物的可溶性环氧化物水解酶抑制剂的
公开(公告)号：EP1987004A2
公开(公告)日：2008-11-05
申请号：EP07757015.8
申请日：2007-02-15
发明人： ELDRUP, Anne, Bettina , FARROW, Neil, Alexander , KOWALSKI, Jennifer, A. , DELOMBAERT, Stephane , MUGGE, Ingo, Andreas , SOLEYMANZADEH, Fariba , SWINAMER, Alan, David , TAYLOR, Steven, John
IPC分类号： C07D213/81 , C07D213/82 , C07D239/34 , A61K31/44 , A61K31/505 , A61P9/00
CPC分类号： C07D213/81 , C07D213/82 , C07D239/34
摘要： Disclosed are compounds active against soluble epoxide hydrolase (sEH), compositions thereof and methods of using and making same.
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公开(公告)号：EP2323991A2
公开(公告)日：2011-05-25
申请号：EP09791162.2
申请日：2009-08-05
IPC分类号： C07D237/32 , C07D403/06 , A61K31/502 , A61P9/00
CPC分类号： C07D237/32 , C07D403/06
摘要： Disclosed are small molecule inhibitors which are useful in treating various diseases and conditions involving chymase (formula I). Also disclosed are pharmaceutical compositions, methods of using and making the same.
摘要翻译： 公开了可用于治疗涉及胃促胰酶的各种疾病和病症的小分子抑制剂。 还公开了药物组合物，使用和制备其的方法。
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公开(公告)号：EP2323991B1
公开(公告)日：2017-05-31
申请号：EP09791162.2
申请日：2009-08-05
IPC分类号： C07D237/32 , C07D403/06 , A61K31/502 , A61P9/00
CPC分类号： C07D237/32 , C07D403/06
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