公开(公告)号：EP0689604A1

公开(公告)日：1996-01-03

申请号：EP94911921.0

申请日：1994-03-18

申请人： BOEHRINGER INGELHEIM INTERNATIONAL GmbH

发明人： BIRNSTIEL, Max L. ,  BUSCHLE, Michael ,  COTTEN, Matthew ,  MAAS, Gerhard ,  PLANK, Christian ,  SCHAFFNER, Gotthold ,  SCHMIDT, Walter ,  WAGNER, Ernst ,  ZATLOUKAL, Kurt

IPC分类号： C12N15 ,  A61K35 ,  A61K39 ,  A61K47 ,  A61K48 ,  A61P35 ,  A61P37 ,  C07K14 ,  C12N5 ,  C12N7 ,  C12P21 ,  C12Q1 ,  A61K38 ,  C12R1

CPC分类号： C12N7/00 ,  A61K38/00 ,  A61K39/0011 ,  A61K47/50 ,  A61K48/00 ,  C07K14/005 ,  C07K14/485 ,  C07K14/535 ,  C07K14/55 ,  C07K14/57 ,  C07K14/705 ,  C12N15/87 ,  C12N2710/10343 ,  C12N2710/10361 ,  C12N2760/20122 ,  C12Q1/701

摘要： Cancer vaccines are prepared by treating tumor cells or fibroblasts with a complex of immunostimulating polypeptide-coding DNA and of DNA-binding substance, for example polylysine, preferably conjugated with transferrine. The complex further contains a conjugate of DNA-binding substance and of an endosomolytic peptide or an adenovirus having at least one E4 defect or one E1a defect associated with other genetic defects.