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1.发明授权VERWENDUNG VON 2-AMINO-6-A-PROPYL-AMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOL (PRAMIPEXOL) ALS ARZNEIMITTEL MIT ANTIDEPRESSIVER WIRKUNG 失效2-氨基-6-甲丙基氨基-4,5,6,7- tetrahydrobenzothiazole（普拉克索）的药物组合物具有抗抑郁活性USE
公开(公告)号：EP0675717B1
公开(公告)日：1999-08-11
申请号：EP94902661.1
申请日：1993-12-02
发明人： HAMMER, Rudolf , MIERAU, Joachim , LEHR, Erich , BORSINI, Franco
IPC分类号： A61K31/425
CPC分类号： A61K31/425
摘要： The invention concerns the use of pramipexol as an anti-depressant drug.
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2.发明授权ADENOSIN-ANTAGONISTEN, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 失效腺苷拮抗剂，其制造方法相同，它们作为药物
公开(公告)号：EP0880524B1
公开(公告)日：2000-04-19
申请号：EP97933683.1
申请日：1997-07-17
发明人： KÜFNER-MÜHL, Ulrike , KUMMER, Werner , POHL, Gerald , GAIDA, Wolfram , LEHR, Erich , MIERAU, Joachim , WEISER, Thomas
IPC分类号： C07D487/14 , A61K31/505
CPC分类号： C07D487/14
摘要： The invention pertains to triazolopurines of formula (I). The claimed compounds show an affinity to adenosine receptors and thus represent a new class of adenosine antagonists. Generally, adenosine antagonists can have a therapeutically useful effect in cases where diseases or pathological situations involve activation of adenosine receptors.
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3.发明公开NEUE TRIAZOLOPURINE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL 失效新三唑并，制造方法相同，它们作为药物
公开(公告)号：EP0880524A1
公开(公告)日：1998-12-02
申请号：EP97933683.0
申请日：1997-07-17
发明人： KÜFNER-MÜHL, Ulrike , KUMMER, Werner , POHL, Gerald , GAIDA, Wolfram , LEHR, Erich , MIERAU, Joachim , WEISER, Thomas
IPC分类号： A61K31 , A61P5 , A61P7 , A61P11 , A61P13 , A61P19 , A61P25 , A61P37 , A61P43 , C07D487 , C07D235 , C07D239 , C07D249
CPC分类号： C07D487/14
摘要： The invention pertains to triazolopurines of formula (I). The claimed compounds show an affinity to adenosine receptors and thus represent a new class of adenosine antagonists. Generally, adenosine antagonists can have a therapeutically useful effect in cases where diseases or pathological situations involve activation of adenosine receptors.
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4.发明公开NEUE UNSYMMETRISCH SUBSTITUIERTE XANTHIN-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL MIT ADENOSINANTAGONISTISCHER WIRKUNG 审中-公开新的取代不平衡黄嘌呤衍生物，其制造方法相同，并且它们作为WITH EFFECT ADENOSINANTAGONISTISCHER DRUGS
公开(公告)号：EP1084123A1
公开(公告)日：2001-03-21
申请号：EP99916914.7
申请日：1999-04-13
发明人： BLECH, Stefan , CARTER, Adrian , GAIDA, Wolfram , GATH, Ursula , HOFFMANN, Matthias , KUEFNER-MUEHL, Ulrike , LEHR, Erich , MIERAU, Joachim , POHL, Gerald , WEISER, Thomas
IPC分类号： C07D473/06 , A61K31/52
CPC分类号： C07D473/06 , C07D473/04
摘要： The invention relates to novel asymmetrically substituted xanthine derivatives of general formula (I), to methods for producing them and to their use as medicaments with an adenosine-antagonistic effect. The broken line between the nitrogen atoms of the general formula (I) indicates the existence of a double bond in one of two possible positions so that the radicals R?4 and R5¿ cannot be present at the same time. R1 cannot have the meaning of R2 at the same time. The radicals R?1, R2, R3, R4 and R5¿ are defined as follows: R1 is hydrogen, C¿1?-C6 alkyl, C3-C6 alkenyl or C3-C6 alkinyl; R?2¿ is a C¿1?-C6 alkyl, C3-C6 alkenyl or C3-C6 alkinyl radical which is substituted by -OR?6, -SO¿2R?6, -OCOR9, -COOR9, -NR7R8¿, -OCH¿2?CH2-NR?7R8, -CONR7R8¿, -OCH¿2?-CONR?7R8¿ or OCH¿2?CH2-CONR?7R8; R2¿ is a C¿1?-C6 alkyl, C3-C6 alkenyl or C3-C6 alkinyl radical which is substituted by a C-bonded 5 or 6-membered heterocyclic ring which may contain 1, 2, 3 or 4 heteroatoms selected from the following group: oxygen, nitrogen or sulphur; and may optionally be substituted by C1-C4 alkyl or benzyl; R?3 is C¿1-C6 alkyl which can be substituted by OH or optionally, norbornanyl, norbornenyl, adamantyl or noradamantyl substituted by methyl or OH and R4 or R5 is hydrogen, benzyl or benzyl substituted once, twice or three times by methoxy. R6 can mean hydrogen, C¿3?-C6 cycloalkyl or C1-C4 alkyl which may be substituted by -OR?9¿ or -OCOR9, R7 can mean hydrogen, -SO¿2R?6, C1-C4 alkyl, -COR9 or -COOR9; R8 can mean hydrogen, -SO¿2R?6, C1-C4 alkyl, -COR9 or -COOR?9 or R7 and R8¿ can form a 5 or 6-membered ring together with the nitrogen, whereby said ring may contain oxygen or nitrogen as a further heteroatom and may optionally be substituted by C¿1?-C4 alkyl or benzyl; and R?9¿ can mean hydrogen or C¿1?-C4 alkyl, optionally in the form of their racemates, their enantiomers, their diastereomers and their mixtures, and optionally in the form of their pharmacologically safe acid addition salts.
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5.发明公开VERWENDUNG VON 2-AMINO-6-A-PROPYL-AMINO-4,5,6,7-TETRAHYDROBENZOTHIAZOL (PRAMIPEXOL) ALS ARZNEIMITTEL MIT ANTIDEPRESSIVER WIRKUNG 失效使用2-氨基-6-甲丙基氨基-4,5,6,7- tetrahydrobenzothiazole（普拉克索）作为抗抑郁活性的药物组合物。
公开(公告)号：EP0675717A1
公开(公告)日：1995-10-11
申请号：EP94902661.0
申请日：1993-12-02
发明人： HAMMER, Rudolf , MIERAU, Joachim , LEHR, Erich , BORSINI, Franco
CPC分类号： A61K31/425
摘要： The invention concerns the use of pramipexol as an anti-depressant drug.
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6.发明公开UNSYMMETRISCH SUBSTITUIERTE XANTHINE MIT ADENOSINANTAGONISTISCHEN EIGENSCHAFTEN 失效不平衡取代的黄嘌呤ADENOSINANTAGONISTISCHEN性能。
公开(公告)号：EP0654033A1
公开(公告)日：1995-05-24
申请号：EP93917743.0
申请日：1993-08-05
发明人： KÜFNER-MÜHL, Ulrike , ENSINGER, Helmut , MIERAU, Joachim , KUHN, Franz, Josef , LEHR, Erich , MÜLLER, Enzio
CPC分类号： C07D473/06
摘要： New xanthine derivatives, a process for preparing the same and their use as medicaments are disclosed, as well as their use as intermediate compounds.
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公开(公告)号：EP0487673A1
公开(公告)日：1992-06-03
申请号：EP91910772.0
申请日：1991-06-19
发明人： KÜFNER-MÜHL, Ulrike , STRANSKY, Werner , WEBER, Karl-Heinz , ENSINGER, Helmut , KUHN, Franz, Josef , SCHINGNITZ, Günter , LEHR, Erich
CPC分类号： C07D473/06 , F05C2201/021
摘要： Nouveaux dérivés de xanthine ayant la formule (I), leur procédé de production et leur utilisation comme médicaments.
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