公开(公告)号：EP1504040A1

公开(公告)日：2005-02-09

申请号：EP03721816.1

申请日：2003-04-21

申请人： BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

发明人： FORNESS, Cecile,Boehringer Ingelheim Pharm. Inc. ,  HORHOTA, S. T.,Boehringer Ingelheim Pharm. Inc. ,  SAIM, Said,Boehringer Ingelheim Pharm. Inc. ,  BOCHNIAK, David,Boehringer Ingelheim Pharm. Inc.

IPC分类号： C08F6/00 ,  C08F6/28 ,  B01D11/02 ,  A61K9/00

CPC分类号： C08F6/28 ,  A61K47/10 ,  B01D11/0203 ,  B01D11/0219 ,  B01D11/028 ,  C08F6/005

摘要： Method for reducing the level of residual organic solvent in a carbomer comprising exposing a carbomer containing residual organic solvent to a gaseous fluid in which said residual organic solvent is substantially soluble and under conditions sufficient to extract at least some of the residual organic solvent from the carbomer; carbomers treated by this method and pharmaceutical suspensions containing the treated carbomer and a therapeutically active agent. This method is effective for the reduction of residual organic solvent in carbomer down to the ppm level, e.g., less than 30 ppm, preferably less than 10 ppm, more preferably less than 2 ppm of residual organic solvent.