公开(公告)号：EP1222187A2

公开(公告)日：2002-07-17

申请号：EP00968713.8

申请日：2000-10-05

申请人： BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

发明人： SNOW, Roger, John ,  CARDOZO, Mario, Gustavo ,  GOLDBERG, Daniel ,  HAMMACH, Abdelhakim ,  MORWICK, Tina ,  MOSS, Neil ,  PATEL, Usha, R. ,  PROKOPOWICZ, Anthony, S., III ,  TAKAHASHI, Hidenori ,  TSCHANTZ, Matt, Aaron ,  WANG, Xiao-jun

IPC分类号： C07D471/04 ,  C07D513/04 ,  C07D498/04 ,  A61K31/437 ,  A61K31/4355 ,  A61P35/00 ,  C07D217/24

CPC分类号： C07D471/04 ,  C07D217/24 ,  C07D235/30 ,  C07D513/04

摘要： Disclosed are novel compounds of formula (I) wherein Ar1, Ra, R4, R5, X and Y are defined below, which are useful as inhibitors of certain protein tyrosina kinases and are thus useful for treating diseases associated with such kinases, for example, diseases resulting from inappropriate cell proliferation, which include autoimmune diseases, chronic inflammatory diseases, allergic diseases, transplant rejection and cancer. Also disclosed are processes for preparing these compounds, novel intermediates useful in these processes and compositions comprising compounds of formula (I).

公开(公告)号：EP1222187B1

公开(公告)日：2004-09-22

申请号：EP00968713.8

申请日：2000-10-05

申请人： BOEHRINGER INGELHEIM PHARMACEUTICALS INC.

发明人： SNOW, Roger, John ,  CARDOZO, Mario, Gustavo ,  GOLDBERG, Daniel ,  HAMMACH, Abdelhakim ,  MORWICK, Tina ,  MOSS, Neil ,  PATEL, Usha, R. ,  PROKOPOWICZ, Anthony, S., III ,  TAKAHASHI, Hidenori ,  TSCHANTZ, Matt, Aaron ,  WANG, Xiao-jun

IPC分类号： C07D471/04 ,  C07D513/04 ,  C07D498/04 ,  A61K31/437 ,  A61K31/4355 ,  A61P35/00 ,  C07D217/24

CPC分类号： C07D471/04 ,  C07D217/24 ,  C07D235/30 ,  C07D513/04

摘要： Disclosed are novel compounds of formula (I) wherein Ar1, Ra, R4, R5, X and Y are defined below, which are useful as inhibitors of certain protein tyrosina kinases and are thus useful for treating diseases associated with such kinases, for example, diseases resulting from inappropriate cell proliferation, which include autoimmune diseases, chronic inflammatory diseases, allergic diseases, transplant rejection and cancer. Also disclosed are processes for preparing these compounds, novel intermediates useful in these processes and compositions comprising compounds of formula (I).