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    GASTRIN RELEASING PEPTIDE COMPOUNDS
    1.
    发明公开
    GASTRIN RELEASING PEPTIDE COMPOUNDS 审中-公开
    胃泌素释放肽CONNECTIONS

    公开(公告)号：EP2291075A4

    公开(公告)日：2012-08-22

    申请号：EP09751329

    申请日：2009-05-19

    申请人： BRACCO IMAGING SPA

    发明人： LATTUADA LUCIANO ,  CAPPELLETTI ENRICO ,  LINDER KAREN E ,  NUNN ADRIAN D ,  LANTRY LAURA

    IPC分类号： A01N37/18 ,  A61K38/00 ,  C07K7/08

    CPC分类号： A61K51/088 ,  A61K49/0056 ,  G01N33/57492 ,  G01N2333/5758

    摘要： Methods and compositions for diagnosing, staging disease, monitoring therapeutic effect of drugs and imaging a patient are provided, including radiopharmaceutical formulations. Compositions comprising Ga-AMBA complexed with a radioactive isotope are provided; as are methods of imaging Gastrin Releasing Peptide receptor (GRP-R) bearing tissue and methods of diagnosing or staging disease in patients suspected of having disease associated with aberrant GRP-R function. Further, methods of monitoring therapeutic effect of a drug targeted to a receptor that crosstalks with GRP-R are provided; as are methods of pre-dosing/co-dosing non-target tissues containing GRP-R. Particularly, methods of monitoring activity of receptors and receptor pathways in vivo/in vitro by using a ligand that binds to the GRP-R are provided; as are methods of measuring the activity of a receptor or group of receptors and their associated pathways that exhibit crosstalk with the GRP-R by using such a ligand which is also detectable by external means.