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公开(公告)号：EP4452931A1
公开(公告)日：2024-10-30
申请号：EP22839646.1
申请日：2022-12-15
申请人： Bracco Imaging SPA
发明人： LATTUADA, Luciano , BEVERINA, Luca , SASSI, Mauro , MATTIELLO, Sara , PAPAGNI, Antonio , ZUCCHI, Anita
IPC分类号： C07C237/32 , C07C231/02
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公开(公告)号：EP4313934A1
公开(公告)日：2024-02-07
申请号：EP22716396.1
申请日：2022-03-21
申请人： Bracco Imaging SPA
IPC分类号： C07C213/02 , C07C231/02 , C07C231/12 , C07D263/24 , C07C215/10 , C07C237/30 , C07C237/46
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公开(公告)号：EP4255894A1
公开(公告)日：2023-10-11
申请号：EP21819134.4
申请日：2021-12-01
申请人： Bracco Imaging SPA
IPC分类号： C07D257/02
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公开(公告)号：EP4234634A2
公开(公告)日：2023-08-30
申请号：EP23168594.2
申请日：2020-05-12
申请人： Bracco Imaging SPA
发明人： BLASI, Francesco , BRIOSCHI, Chiara , BUONSANTI, Federica , MIRAGOLI, LUIGI , NAPOLITANO, Roberta , ORIO, Laura , PIZZUTO, Lorena , VALBUSA, Giovanni
IPC分类号： C09B23/08
摘要： The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family characterized by improved physico-chemical and biological properties and to their conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.
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公开(公告)号：EP3969063A1
公开(公告)日：2022-03-23
申请号：EP20723888.2
申请日：2020-05-12
申请人： Bracco Imaging SPA
发明人： BLASI, Francesco , BRIOSCHI, Chiara , BUONSANTI, Federica , MIRAGOLI, Luigi , NAPOLITANO, Roberta , ORIO, Laura , PIZZUTO, Lorena , VALBUSA, Giovanni
IPC分类号： A61K49/00 , C07D471/18 , A61K39/00 , C07K7/52 , C07K16/28 , C07D209/14 , C07D403/12 , C07D417/14
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公开(公告)号：EP3687994B1
公开(公告)日：2020-11-04
申请号：EP19753296.3
申请日：2019-08-06
申请人： Bracco Imaging SPA
发明人： NAPOLITANO, Roberta , LATTUADA, Luciano , BARANYAI, Zsolt , GUIDOLIN, Nicole , MARAZZI, Giuseppe
IPC分类号： C07D471/08 , A61K49/10
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公开(公告)号：EP3260443B1
公开(公告)日：2020-10-07
申请号：EP17182061.6
申请日：2012-04-05
申请人： Bracco Imaging SPA
发明人： ANELLI, Pier Lucio , ARGESE, Maria , BOI, Valeria , CAVALIERI, Livio , GALIMBERTI, Laura , GAZZETTO, Sonia , LATTUADA, Luciano , MAISANO, Federico , RIVOLTA, Giovanni , VELLA, Fulvia
IPC分类号： A61P5/14 , A61P43/00 , C07C303/24 , C07C303/44 , G01N33/78
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公开(公告)号：EP3609892A1
公开(公告)日：2020-02-19
申请号：EP18717573.2
申请日：2018-04-10
申请人： Bracco Imaging SpA
发明人： LATTUADA, Luciano , BUONSANTI, Federica , CRIVELLIN, Federico , FERRETTI, Fulvio , MAISANO, Federico , ORIO, Laura , PIZZUTO, Lorena
IPC分类号： C07D471/18 , C07K7/64 , C09B23/08 , A61K49/00
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公开(公告)号：EP2291075A4
公开(公告)日：2012-08-22
申请号：EP09751329
申请日：2009-05-19
申请人： BRACCO IMAGING SPA
CPC分类号： A61K51/088 , A61K49/0056 , G01N33/57492 , G01N2333/5758
摘要： Methods and compositions for diagnosing, staging disease, monitoring therapeutic effect of drugs and imaging a patient are provided, including radiopharmaceutical formulations. Compositions comprising Ga-AMBA complexed with a radioactive isotope are provided; as are methods of imaging Gastrin Releasing Peptide receptor (GRP-R) bearing tissue and methods of diagnosing or staging disease in patients suspected of having disease associated with aberrant GRP-R function. Further, methods of monitoring therapeutic effect of a drug targeted to a receptor that crosstalks with GRP-R are provided; as are methods of pre-dosing/co-dosing non-target tissues containing GRP-R. Particularly, methods of monitoring activity of receptors and receptor pathways in vivo/in vitro by using a ligand that binds to the GRP-R are provided; as are methods of measuring the activity of a receptor or group of receptors and their associated pathways that exhibit crosstalk with the GRP-R by using such a ligand which is also detectable by external means.
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