公开(公告)号：EP2238449A2

公开(公告)日：2010-10-13

申请号：EP09703925.9

申请日：2009-01-26

申请人： Balter, Inc.

发明人： STAMNES, Jakob, J. ,  STAMNES, Knut ,  RYZHIKOV, Gennady ,  BIRYULINA, Marina ,  HAMRE, Boerge ,  SOMMERSTEN, Endre, R. ,  ZHAO, Lu

IPC分类号： G01N33/483 ,  G06F19/00

CPC分类号： A61B5/444 ,  A61B5/0075 ,  A61B5/0077 ,  A61B5/1079 ,  A61B5/7264 ,  G06F19/00 ,  G06T7/0012 ,  G06T7/44 ,  G06T2207/20036 ,  G06T2207/30088 ,  G16H50/20

摘要： An embodiment of the present invention includes a method for discriminating between benign and malignant tissue lesions. The method includes the steps of using a plurality of maps of physiology and morphology parameters generated from reflectance measurements and pure morphology parameters generated from reflectance measurements. The method also includes calculating entropies and cross entropies of the plurality of maps, and calculating a plurality of pure morphology parameters. Further, the method includes assigning a weight to each entropy and a weight to a logarithm of each entropy, a weight to each cross entropy and a weight to a logarithm of each cross entropy, and a weight to each pure morphology parameter and a weight to a logarithm of each pure morphoiogy parameter. The method further includes computing a diagnostic index, defining a cost function, defining a proper threshold value for a diagnostic index and solving an optimization problem to determine a set of weights from the assigned weights to maximize specificity for 100% sensitivity. Further, the method uses calculations, the cost function and the diagnostic index to determine whether the tissue lesion is benign or malignant.

摘要翻译： 本发明的一个实施例包括用于区分良性和恶性组织损伤的方法。 该方法包括以下步骤：使用从反射测量产生的生理学和形态参数的多个图，以及由反射测量产生的纯形态参数。 该方法还包括计算多个地图的熵和交叉熵，以及计算多个纯形态参数。 此外，该方法包括将每个熵的权重和每个熵对数的权重，每个交叉熵的权重和每个交叉熵的对数的权重以及对每个纯形态参数的权重以及权重分配给每个熵 每个纯形态参数的对数。 该方法还包括计算诊断索引，定义成本函数，为诊断索引定义适当的阈值并解决优化问题，以从所分配的权重确定一组权重，以最大限度地提高100％灵敏度的特异性。 此外，该方法使用计算，成本函数和诊断指标来确定组织损伤是否良性或恶性。

公开(公告)号：EP2238449B1

公开(公告)日：2018-06-06

申请号：EP09703925.9

申请日：2009-01-26

申请人： Balter, Inc.

发明人： STAMNES, Jakob, J. ,  STAMNES, Knut ,  RYZHIKOV, Gennady ,  BIRYULINA, Marina ,  HAMRE, Boerge ,  SOMMERSTEN, Endre, R. ,  ZHAO, Lu

IPC分类号： G16H50/20

CPC分类号： A61B5/444 ,  A61B5/0075 ,  A61B5/0077 ,  A61B5/1079 ,  A61B5/7264 ,  G06F19/00 ,  G06T7/0012 ,  G06T7/44 ,  G06T2207/20036 ,  G06T2207/30088 ,  G16H50/20

摘要： An embodiment of the present invention includes a method for discriminating between benign and malignant tissue lesions. The method includes the steps of using a plurality of maps of physiology and morphology parameters generated from reflectance measurements and pure morphology parameters generated from reflectance measurements. The method also includes calculating entropies and cross entropies of the plurality of maps, and calculating a plurality of pure morphology parameters. Further, the method includes assigning a weight to each entropy and a weight to a logarithm of each entropy, a weight to each cross entropy and a weight to a logarithm of each cross entropy, and a weight to each pure morphology parameter and a weight to a logarithm of each pure morphoiogy parameter. The method further includes computing a diagnostic index, defining a cost function, defining a proper threshold value for a diagnostic index and solving an optimization problem to determine a set of weights from the assigned weights to maximize specificity for 100% sensitivity. Further, the method uses calculations, the cost function and the diagnostic index to determine whether the tissue lesion is benign or malignant.

公开(公告)号：EP2255173B1

公开(公告)日：2018-01-24

申请号：EP09722309.3

申请日：2009-03-18

申请人： Balter, Inc.

发明人： STAMNES, Jakob, J. ,  STAMNES, Knut ,  ZHAO, Lu ,  HAMRE, Boerge ,  RYZHIKOV, Gennady ,  BIRYULINA, Marina ,  SOMMERSTEN, Endre, R. ,  NIELSEN, Kristian, P. ,  MOAN, Johan, E.

IPC分类号： A61B5/1455 ,  A61B5/00 ,  G01N21/47 ,  G01N21/31 ,  G06K9/00 ,  G06T7/62 ,  G06T7/66

CPC分类号： G01N21/4738 ,  A61B5/0059 ,  A61B5/1455 ,  A61B5/444 ,  G06K9/00134 ,  G06T7/62 ,  G06T7/66 ,  G06T2207/30024

摘要： An optical method for determining morphological parameters of a tissue lesion comprises: generating a reflectance image of the lesion using an optical transfer diagnosis device; and determining a lesion border, a size of the lesion, a histogram width that gives a measure of inhomogeneity of the reflectance image of the lesion, a relative moment of inertia of the lesion, a center distance representing a physical distance between a geometrical center of the lesion and a center of mass of absorptance, a fractal dimension of the lesion that describes the complexity of its border, an asphericity of the lesion, a relative border length of the lesion, and, optionally, a darkness of the lesion defined as an average value of the reflected intensity of the lesion.

公开(公告)号：EP2255173A2

公开(公告)日：2010-12-01

申请号：EP09722309.3

申请日：2009-03-18

申请人： Balter, Inc.

发明人： STAMNES, Jakob, J. ,  STAMNES, Knut ,  ZHAO, Lu ,  HAMRE, Boerge ,  RYZHIKOV, Gennady ,  BIRYULINA, Marina ,  SOMMERSTEN, Endre, R. ,  NIELSEN, Kristian, P. ,  MOAN, Johan, E.

IPC分类号： G01N21/31 ,  G01N33/483

CPC分类号： G01N21/4738 ,  A61B5/0059 ,  A61B5/1455 ,  A61B5/444 ,  G06K9/00134 ,  G06T7/62 ,  G06T7/66 ,  G06T2207/30024

摘要： In an embodiment of the present disclosure, an optical method for determining morphological parameters and physiological properties of tissue is presented. The method includes using reflectance measurements from a tissue area for a plurality of wavelengths, using a bio-optical model, using radiative transfer modeling and using a non-linear inversion procedure. The method further includes systematically varying values of the morphological parameters and physiological properties of the tissue and simultaneously varying the inherent optical properties, which are linked to the morphological parameters and the physiological properties of the tissue, until the non-linear inversion procedure returns values for the morphological parameters and the physiological properties of the tissue such that an agreement between the reflectance measurements and reflectances computed by the radiative transfer model, based on the returned morphological parameters and the physiological properties of the tissue values and corresponding inherent optical properties values, reach a predetermined level of accuracy.

公开(公告)号：EP2992818B1

公开(公告)日：2019-09-04

申请号：EP15186132.5

申请日：2009-03-18

申请人： Balter, Inc.

发明人： STAMNES, Jakob, J. ,  STAMNES, Knut ,  ZHAO, Lu ,  HAMRE, Boerge ,  RYZHIKOV, Gennady ,  BIRYULINA, Marina ,  SOMMERSTEN, Endre, R. ,  NIELSEN, Kristian, P. ,  MOAN, Johan, E.

IPC分类号： A61B5/00 ,  A61B5/1455 ,  G01N21/47 ,  G06T7/62 ,  G06T7/66 ,  G06K9/00

公开(公告)号：EP2992818A1

公开(公告)日：2016-03-09

申请号：EP15186132.5

申请日：2009-03-18

申请人： Balter, Inc.

发明人： STAMNES, Jakob, J. ,  STAMNES, Knut ,  ZHAO, Lu ,  HAMRE, Boerge ,  RYZHIKOV, Gennady ,  BIRYULINA, Marina ,  SOMMERSTEN, Endre, R. ,  NIELSEN, Kristian, P. ,  MOAN, Johan, E.

IPC分类号： A61B5/00 ,  A61B5/1455 ,  G01N21/47 ,  G06T7/60

CPC分类号： G01N21/4738 ,  A61B5/0059 ,  A61B5/1455 ,  A61B5/444 ,  G06K9/00134 ,  G06T7/62 ,  G06T7/66 ,  G06T2207/30024

摘要： An optical method for determining morphological parameters of a tissue lesion comprises: generating a reflectance image of the lesion using an optical transfer diagnosis device; and determining a lesion border, a size of the lesion, a histogram width that gives a measure of inhomogeneity of the reflectance image of the lesion, a relative moment of inertia of the lesion, a center distance representing a physical distance between a geometrical center of the lesion and a center of mass of absorptance, a fractal dimension of the lesion that describes the complexity of its border, an asphericity of the lesion, a relative border length of the lesion, and, optionally, a darkness of the lesion defined as an average value of the reflected intensity of the lesion.