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1.发明授权BRACHYTHERAPY SEED WITH FAST DISSOLVING MATRIX FOR OPTIMAL DELIVERY OF RADIONUCLIDES TO CANCER TISSUE 有权带快速分辨率MATRIX近距离放射治疗种子的放射性核素最佳释放癌组织
公开(公告)号：EP2331064B1
公开(公告)日：2013-08-28
申请号：EP09792174.6
申请日：2009-09-02
CPC分类号： A61N5/1001 , A61B90/39 , A61B2090/3966 , A61K9/0024 , A61K9/1647 , A61K45/06 , A61K51/0491 , A61K51/06 , A61K51/1251 , A61N2005/1024 , A61N2005/1087 , A61N2005/1089 , B29B7/945 , B29B2009/163 , B29C43/003 , B29C43/027 , B29K2067/046 , B29K2995/0037 , B29K2995/006
摘要： A system, method and device for treating tumor cells utilizing a resorbable therapy seed made up of microspheres containing a beta- or alpha-particle-emitting radiation source and a resorbable polymer matrix. These seeds are implanted within the tumor and then rapidly dissolved so as to release the microspheres from the polymer matrix. These microspheres then spread within a preselected target area and provide radiation therapy in a predetermined amount and at a preselected rate according the specific needs and necessities of the users. The configuration of the microspheres, the types of radiation provided and the location and use of these microspheres provides desired localized treatment to target cells while preferentially avoiding or minimizing undesired damage to surrounding tissue. The present invention provides a method for making the seeds, as well as a method for utilizing the seeds as a part of the treatment method.
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2.发明公开INJECTABLE BIODEGRADABLE BLOCK COPOLYMER GELS FOR USE IN DRUG DELIVERY 审中-公开注射生物可降解嵌段共聚物的凝胶FOR USE IN药品管理
公开(公告)号：EP1024790A1
公开(公告)日：2000-08-09
申请号：EP98940801.8
申请日：1998-08-08
CPC分类号： A61K9/0024 , A61K9/1075 , A61K47/34 , C08L71/02 , C08L2666/18
摘要： A system and method for the parenteral delivery of a drug in a biodegradable polymeric matrix to a warm blooded animal as an aqueous liquid with the resultant formation of a hydrogel depot for the controlled release of the drug. The system comprises an injectable biodegradable block copolymeric drug delivery liquid having thermal gelation properties. The copolymer has a gel/sol transition temperature such that, above the body temperature of the animal to which it is administered, it is a solution and when administered and cooled to body temperature it forms a hydrogel. The copolymer is made up of (i) a hydrophobic A polymer block of poly (α-hydroxy acid) and (ii) a hydrophilic B polymer block comprising a poly(ethylene oxide). The drug is released at a controlled rate from the copolymer which biodegrades into non-toxic products. The gel/sol transition temperature and degradation rate can be adjusted by proper selection of the molecular weight and concentration of the poly (α-hydroxy acid) and poly(ethylene oxide) polymer block components.
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公开(公告)号：EP3223859A1
公开(公告)日：2017-10-04
申请号：EP15854949.3
申请日：2015-10-30
申请人： University of Utah Research Foundation , Bae, You Han , Lee, Yong-Kyu , Nurunnabi, Md , Hwang, Hee, Sook , Kwag, Dongsub
发明人： BAE, You, Han , LEE, Yong-Kyu , NURUNNABI, Md , HWANG, Hee, Sook , KWAG, Dongsub
IPC分类号： A61K47/54
CPC分类号： A61K9/1652 , A61K9/5036 , A61K9/5169 , A61K31/704 , A61K38/26 , A61K38/28 , A61K47/48038 , A61K47/542 , A61K47/554 , A61K47/59 , A61K47/61 , A61K47/645 , A61K47/6455
摘要： Therapeutic compositions are disclosed which contain a therapeutic agent and a bile acid or bile acid conjugate. The compositions can be absorbed via enterohepatic circulation. The compositions include a cationic moiety and an anionic polymer, which are coupled through electrostatic interactions. The therapeutic compositions can be used for the treatment of diseases or disorders.
摘要翻译： 公开了含有治疗剂和胆汁酸或胆汁酸缀合物的治疗组合物。 该组合物可以通过肠肝循环吸收。 该组合物包含通过静电相互作用偶联的阳离子部分和阴离子聚合物。 治疗组合物可以用于治疗疾病或病症。
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4.发明公开BRACHYTHERAPY SEED WITH FAST DISSOLVING MATRIX FOR OPTIMAL DELIVERY OF RADIONUCLIDES TO CANCER TISSUE 有权带快速分辨率MATRIX近距离放射治疗种子的放射性核素最佳释放癌组织
公开(公告)号：EP2331064A1
公开(公告)日：2011-06-15
申请号：EP09792174.6
申请日：2009-09-02
CPC分类号： A61N5/1001 , A61B90/39 , A61B2090/3966 , A61K9/0024 , A61K9/1647 , A61K45/06 , A61K51/0491 , A61K51/06 , A61K51/1251 , A61N2005/1024 , A61N2005/1087 , A61N2005/1089 , B29B7/945 , B29B2009/163 , B29C43/003 , B29C43/027 , B29K2067/046 , B29K2995/0037 , B29K2995/006
摘要： A system, method and device for treating tumor cells utilizing a resorbable therapy seed made up of microspheres containing a beta- or alpha-particle- emitting radiation source and a resorbable polymer matrix. These seeds are implanted within the tumor and then rapidly dissolved so as to release the microspheres from the polymer matrix. These microspheres then spread within a preselected target area and provide radiation therapy in a predetermined amount and at a preselected rate according the specific needs and necessities of the users. The configuration of the microspheres, the types of radiation provided and the location and use of these microspheres provides desired localized treatment to target cells while preferentially avoiding or minimizing undesired damage to surrounding tissue. The present invention provides a method for making the seeds, as well as the use of said seeds for the manufacture of a medicament for treating cancer.
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