公开(公告)号：EP3304638A1

公开(公告)日：2018-04-11

申请号：EP15892810.1

申请日：2015-05-27

申请人： Apollo Microwaves Ltd.

发明人： CARIGNAN, Louis-Philippe ,  TSOUNIS, Vasilios

IPC分类号： H01P1/39 ,  H01P1/30

CPC分类号： H01P1/383 ,  A61N5/10 ,  A61N2005/1087 ,  A61N2005/1089 ,  H01F7/202 ,  H01P1/39 ,  H01P7/10 ,  H05K7/2039

摘要： An E-plane waveguide circulator for use in a high power microwave circuit is provided. The circulator has three or more waveguide ports intersecting at a junction, wherein the junction has an upper inner surface and a lower inner surface positioned in an opposing relationship to said upper inner surface. The circulator further includes at least one radial composite resonator positioned within the junction, the resonator being comprised of a composite made of a centrally disposed ferrite element and a solid dielectric layer disposed concentrically with and adjacent externally to said centrally disposed ferrite element. In use, a magnetic field source applies an external magnetic field to the radial composite resonator, the external magnetic field having a magnitude above the magnetic resonance associated with the radial composite resonator.

公开(公告)号：EP3265176A1

公开(公告)日：2018-01-10

申请号：EP16759347.4

申请日：2016-03-01

申请人： The Regents of the University of California

发明人： SHENG, Ke ,  RUAN, Dan ,  LOW, Dan A.

IPC分类号： A61N5/10 ,  A61N5/00

CPC分类号： A61N5/103 ,  A61N5/1047 ,  A61N5/1049 ,  A61N5/1082 ,  A61N2005/105 ,  A61N2005/1059 ,  A61N2005/1087 ,  A61N2005/1089 ,  A61N2005/109

摘要： In various embodiments, methods and devices are provided for generating a radiotherapy treatment plan for a subject to be implemented on a radiotherapy device. In certain embodiments the methods involve determining all feasible radiotherapy beam orientations free of collision for said radiotherapy device and said subject to provide a set of radiotherapy beam orientations; selecting from the set of all feasible radiotherapy beam orientations a subset of beams that meet treatment goals to be used in treatment of the subject to provide a selected beam set; calculating a navigation trajectory for the radiotherapy device to delivery said subset of beams to the subject where the trajectory is free of collision; and generating and writing instruction files to a tangible medium that can be executed by said radiotherapy device.

公开(公告)号：EP3229905A1

公开(公告)日：2017-10-18

申请号：EP15820617.7

申请日：2015-12-04

申请人： Koninklijke Philips N.V.

发明人： RANGANATHAN, Vaitheeswaran ,  JOE ANTO, Gipson ,  KUMAR, Prashant

IPC分类号： A61N5/10

CPC分类号： A61N5/1031 ,  A61N5/1081 ,  A61N2005/1074 ,  A61N2005/1089

摘要： A method and related system to adjust an existing treatment plan. A second optimization is run based on a dual objective function system that includes a first objective function used for the optimization in respect of the existing plan and a second, extended objective function that includes the said first objective function as a functional component.

摘要翻译： 调整现有治疗计划的方法和相关系统。 基于双目标函数系统运行第二优化，该双目标函数系统包括用于关于现有计划的优化的第一目标函数和包括所述第一目标函数作为功能部件的第二扩展目标函数。

公开(公告)号：EP3180084A1

公开(公告)日：2017-06-21

申请号：EP15745211.1

申请日：2015-08-04

申请人： Koninklijke Philips N.V.

发明人： ISOLA, Alfonso Agatino ,  FONTANAROSA, Davide

IPC分类号： A61N5/10

CPC分类号： A61N5/1031 ,  A61N5/1037 ,  A61N5/1045 ,  A61N2005/1089

摘要： Method and apparatus (DMS) for dosage management in radiation therapy planning and/or delivery. Images of a region of interest ROI are acquired at different times. A registration transformation is computed that deforms one of the two images into the other. A magnitude of the transformation is then computed based on a suitable metric. If the computed magnitude is found to comply with a pre-defined criterion, the transformation is used to deform a dose distribution map and compute, based on the deformed dose map, therefrom a new fluence map.

摘要翻译： 用于放射疗法计划和/或递送中的剂量管理的方法和设备（DMS）。 感兴趣区域ROI的图像在不同时间获取。 计算配准变换，将两个图像中的一个变形为另一个。 然后基于合适的度量计算变换的幅度。 如果发现所计算的量值符合预定标准，则使用该变换来使剂量分布图变形并基于变形的剂量图计算新的注量图。

公开(公告)号：EP3043863A4

公开(公告)日：2017-05-17

申请号：EP14844431

申请日：2014-09-11

申请人： UNIV LELAND STANFORD JUNIOR

发明人： FAHRIG REBECCA ,  LOO BILLY WISEMAN ,  MAXIM PETER G ,  TANTAWI SAMI

IPC分类号： A61N5/10 ,  A61N7/02 ,  G21K5/04 ,  H05H1/00 ,  H05H9/04 ,  H05H15/00

CPC分类号： A61N5/1084 ,  A61N5/1039 ,  A61N5/1043 ,  A61N5/1045 ,  A61N5/1064 ,  A61N5/1067 ,  A61N5/1078 ,  A61N5/1081 ,  A61N7/02 ,  A61N2005/1055 ,  A61N2005/1058 ,  A61N2005/1076 ,  A61N2005/1089 ,  A61N2005/1091 ,  A61N2005/1098 ,  H05H9/048 ,  H05H2007/048

摘要： Methods and system for facilitating rapid radiation treatments are provided herein and relate in particular to radiation generation and delivery, electron source design, beam control and shaping/intensity-modulation. The methods and systems described herein are particularly advantageous when used with a compact high-gradient, very high energy electron (VHEE) accelerator and delivery system (and related processes) capable of treating patients from multiple beam directions with great speed, using all-electromagnetic or radiofrequency deflection steering is provided; or when used with a high-current electron accelerator system of energy range more conventionally used in photon radiation therapy to produce much faster delivery of intensity-modulated photon radiation therapy, that can in both cases deliver an entire dose or fraction of high-dose radiation therapy sufficiently fast to freeze physiologic motion, yet with a equal or better degree of dose conformity or sculpting compared to conventional photon therapy.

摘要翻译： 本文提供了用于促进快速辐射治疗的方法和系统，并且具体涉及辐射产生和输送，电子源设计，束控制和成形/强度调制。 本文描述的方法和系统当与紧凑的高梯度，超高能量电子（VHEE）加速器和递送系统（以及相关处理）一起使用时特别有利，其能够使用全电磁波 或提供射频偏转转向; 或者当与通常用于光子放射疗法的能量范围的高电流电子加速器系统一起使用以产生更快速的强度调制光子放射治疗的递送时，可以在两种情况下递送全剂量或部分高剂量辐射 治疗足以快速冻结生理运动，但与常规光子疗法相比，具有相同或更好的剂量一致性或雕刻程度。

公开(公告)号：EP2970289A1

公开(公告)日：2016-01-20

申请号：EP13814691.5

申请日：2013-12-06

申请人： Vertex Pharmaceuticals Inc.

发明人： BRENCHLEY, Guy ,  CHARRIER, Jean-damien ,  DAVIS, Chris ,  DURRANT, Steven ,  JARDI, Gorka, Etxebarria I ,  FRAYSSE, Damien ,  JIMENEZ, Juan-miguel ,  KAY, David ,  KNEGTEL, Ronald ,  PIERARD, Francoise ,  PINDER, Joanne ,  SHAW, David ,  STORCK, Pierre-henri ,  STUDLEY, John ,  TWIN, Heather

IPC分类号： C07D487/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D487/04 ,  A61K31/36 ,  A61K31/4188 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/7068 ,  A61K33/24 ,  A61K45/06 ,  A61N5/1028 ,  A61N5/1077 ,  A61N2005/1087 ,  A61N2005/1089 ,  A61N2005/109 ,  C07D453/02 ,  C07D471/08 ,  C07D491/107 ,  C07D519/00 ,  C12N9/12 ,  C12Y207/11001

摘要： The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in
in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (I) or a pharmaceutically acceptable salt, wherein the variables are as defined herein.

摘要翻译： 本发明涉及用作ATR蛋白激酶抑制剂的化合物。 本发明还涉及包含本发明化合物的药学上可接受的组合物; 使用本发明化合物治疗各种疾病，病症和病症的方法; 制备本发明化合物的方法; 用于制备本发明化合物的中间体; 以及在体外应用中使用这些化合物的方法，例如生物学和病理学现象中的激酶研究; 这种激酶介导的细胞内信号转导途径的研究; 和新的激酶抑制剂的比较评估。 本发明化合物具有式（I）或其药学上可接受的盐，其中变量如本文所定义。

公开(公告)号：EP2811991A1

公开(公告)日：2014-12-17

申请号：EP13746071.3

申请日：2013-02-11

申请人： The Whitehead Institute for Biomedical Research

发明人： DOHOON, Kim ,  SABATINI, David, M. ,  POSSEMATO, Richard

IPC分类号： A61K31/145 ,  A61K31/7088 ,  A61K45/06 ,  A61P35/00 ,  G01N33/53

CPC分类号： C12N15/1137 ,  A61K31/145 ,  A61K31/7088 ,  A61K45/06 ,  A61N5/1001 ,  A61N5/1077 ,  A61N2005/1087 ,  A61N2005/1089 ,  A61N2005/109 ,  C12N2310/14 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/573 ,  G01N33/57407 ,  G01N2333/91028 ,  G01N2500/04 ,  G01N2800/52 ,  A61K2300/00

摘要： In some aspects, methods of inhibiting survival or proliferation of a tumor cell are provided, the methods comprising inhibiting the glycine cleavage system (GCS) of the tumor cell. In some aspects, methods of treating a subject in need of treatment for a tumor, the method comprising inhibiting the GCS in the tumor. In some embodiments, the methods comprise contacting a tumor cell or tumor with a GCS inhibitor. In some embodiments, the tumor cell or tumor has elevated expression of serine hydroxymethyltransferase 2 (SH1VIT2). In some aspects, methods of identifying a tumor cell or tumor that is sensitive to inhibiting the GCS are provided, the methods comprising determining whether the tumor cell or tumor overexpresses SHMT2. In some aspects, methods of identifying a candidate anti-cancer agent are provided, the methods comprising identifying or modifying a GCS inhibitor.

公开(公告)号：EP2711075A2

公开(公告)日：2014-03-26

申请号：EP13189150.9

申请日：2009-03-11

申请人： Immunolight, LLC. ,  Duke University

发明人： Bourke, Frederic A., Jr. ,  Vo-Dinh, Tuan

IPC分类号： B01J19/08 ,  A23L3/26

CPC分类号： A61N5/10 ,  A23L2/50 ,  A23L3/26 ,  A23L3/263 ,  A23L3/28 ,  A23L5/32 ,  A23V2002/00 ,  A61K41/0057 ,  A61K41/0066 ,  A61L2/0011 ,  A61L2/0047 ,  A61L2/0076 ,  A61L2/082 ,  A61L2/088 ,  A61L2/10 ,  A61L2/16 ,  A61L2202/21 ,  A61L2202/22 ,  A61M1/3683 ,  A61N5/062 ,  A61N5/0624 ,  A61N2005/0661 ,  A61N2005/0662 ,  A61N2005/1087 ,  A61N2005/1089 ,  A61N2005/1098 ,  B01J19/082 ,  B01J19/085 ,  B01J19/12 ,  B01J19/123 ,  B01J19/125 ,  B01J19/127 ,  B01J19/128 ,  B01J23/50 ,  B01J23/52 ,  B01J31/0275 ,  B01J31/2295 ,  B01J35/0006 ,  B01J35/0013 ,  B01J35/004 ,  B01J37/0072 ,  B01J37/0221 ,  B01J2219/0877 ,  B01J2219/0879 ,  B01J2219/0892 ,  B01J2219/1203 ,  B01J2231/005 ,  B01J2531/005 ,  B01J2531/008 ,  B82Y20/00 ,  B82Y30/00 ,  B82Y40/00 ,  C02F1/30 ,  C02F1/302 ,  C02F1/305 ,  C02F1/307 ,  C02F1/32 ,  C02F1/725 ,  C02F2305/10 ,  C08J3/24 ,  C08J3/28 ,  C08J7/18 ,  C08J2300/00 ,  C09D201/00 ,  C09J5/00 ,  C09J201/00 ,  C09J2205/31 ,  C12H1/06 ,  G02B5/008 ,  G21K5/00 ,  Y02W10/37 ,  Y10S977/774 ,  Y10S977/777 ,  Y10S977/896 ,  Y10S977/915 ,  Y10T156/10

摘要： A method and a system for producing a change in a medium disposed in an artificial container. The method places in a vicinity of the medium at least one of a plasmonics agent and an energy modulation agent. The method applies an initiation energy through the artificial container to the medium. The initiation energy interacts with the plasmonics agent or the energy modulation agent to directly or indirectly produce the change in the medium. The system includes an initiation energy source configured to apply an initiation energy to the medium to activate the plasmonics agent or the energy modulation agent.

摘要翻译： 一种方法，以及用于在置于人工容器内的介质中产生改变的系统。 在介质中等离子体激元试剂中的至少一个，并且能量调节剂的附近的方法的地方。 该方法适用穿过人工容器至介质以引发能量。 引发能量间行为与等离子体激元试剂或所述能量调节剂以直接或间接产生在介质中的变化。 该系统包括在引发能量源，其配置适用于引发能量至所述介质以激活等离子体激元试剂或所述能量调节剂。

公开(公告)号：EP2331064B1

公开(公告)日：2013-08-28

申请号：EP09792174.6

申请日：2009-09-02

申请人： Battelle Memorial Institute ,  University Of Utah Research Foundation

发明人： FISHER, Darrell, R. ,  BAE, You, Han ,  GAO, Zhonggao

IPC分类号： A61K9/16 ,  A61K9/00 ,  A61N5/10 ,  A61K51/00 ,  A61K51/06 ,  A61K51/12

CPC分类号： A61N5/1001 ,  A61B90/39 ,  A61B2090/3966 ,  A61K9/0024 ,  A61K9/1647 ,  A61K45/06 ,  A61K51/0491 ,  A61K51/06 ,  A61K51/1251 ,  A61N2005/1024 ,  A61N2005/1087 ,  A61N2005/1089 ,  B29B7/945 ,  B29B2009/163 ,  B29C43/003 ,  B29C43/027 ,  B29K2067/046 ,  B29K2995/0037 ,  B29K2995/006

摘要： A system, method and device for treating tumor cells utilizing a resorbable therapy seed made up of microspheres containing a beta- or alpha-particle-emitting radiation source and a resorbable polymer matrix. These seeds are implanted within the tumor and then rapidly dissolved so as to release the microspheres from the polymer matrix. These microspheres then spread within a preselected target area and provide radiation therapy in a predetermined amount and at a preselected rate according the specific needs and necessities of the users. The configuration of the microspheres, the types of radiation provided and the location and use of these microspheres provides desired localized treatment to target cells while preferentially avoiding or minimizing undesired damage to surrounding tissue. The present invention provides a method for making the seeds, as well as a method for utilizing the seeds as a part of the treatment method.

公开(公告)号：EP2279833B1

公开(公告)日：2013-06-05

申请号：EP10169458.6

申请日：2010-07-13

申请人： ITEL Telecomunicazioni S.r.l.

发明人： Diaferia, Leonardo ,  Dimiccoli, Vincenzo

IPC分类号： B25J9/00

CPC分类号： A61N5/1078 ,  A61N5/1049 ,  A61N2005/1087 ,  A61N2005/1089 ,  B25J5/02 ,  B25J9/0018 ,  B25J9/009