公开(公告)号：EP4039249A1

公开(公告)日：2022-08-10

申请号：EP22164436.2

申请日：2011-05-26

申请人： Baxalta GmbH ,  Baxalta Incorporated

发明人： Teschner, Wolfgang ,  Schwarz, Hans-Peter ,  Madlener, Ruth ,  Svatos, Sonja ,  Pljevljakovic, Azra ,  Weber, Alfred

IPC分类号： A61K9/08 ,  A61K47/18 ,  A61K9/00 ,  A61K38/17 ,  C07K16/00 ,  A61K35/16 ,  A61P7/00 ,  A61P13/12 ,  A61P27/02 ,  A61P31/00 ,  A61P37/00 ,  A61P37/02 ,  A61P37/04 ,  A61P37/06 ,  C07K1/30 ,  C07K1/36 ,  C07K16/06

摘要： The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and/or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.