公开(公告)号：EP2809326B1

公开(公告)日：2018-07-25

申请号：EP13704317.0

申请日：2013-01-30

申请人： Baxalta GmbH ,  Baxalta Incorporated

发明人： DOCKAL, Michael ,  SCHEIFLINGER, Fritz ,  KNAPPE, Sabine ,  TILL, Susanne ,  HAI, Ton ,  SANDERS, Paul ,  DANDE, Prasad ,  JIANG, Cong

IPC分类号： A61K31/715 ,  A61P7/04

CPC分类号： A61K31/737 ,  A61K31/715 ,  A61K45/06 ,  C07H5/10 ,  C08B37/0012 ,  A61K2300/00

摘要： The present invention provides non-anticoagulant sulfated or sulfonated polysaccharides (NASPs), which accelerate the blood clotting process. Also provided are pharmaceutical formulations comprising a NASP of the invention in conjunction with a pharmaceutically acceptable excipient and, in various embodiments, these formulations are unit dosage formulations. The invention provides a NASP formulation, which is orally bioavailable. Also provided are methods for utilizing the compounds and formulations of the invention to promote blood clotting in vivo as therapeutic and prophylactic agents and in vitro as an aid to studies of the blood clotting process.