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公开(公告)号：EP2809326B1
公开(公告)日：2018-07-25
申请号：EP13704317.0
申请日：2013-01-30
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： DOCKAL, Michael , SCHEIFLINGER, Fritz , KNAPPE, Sabine , TILL, Susanne , HAI, Ton , SANDERS, Paul , DANDE, Prasad , JIANG, Cong
IPC分类号： A61K31/715 , A61P7/04
CPC分类号： A61K31/737 , A61K31/715 , A61K45/06 , C07H5/10 , C08B37/0012 , A61K2300/00
摘要： The present invention provides non-anticoagulant sulfated or sulfonated polysaccharides (NASPs), which accelerate the blood clotting process. Also provided are pharmaceutical formulations comprising a NASP of the invention in conjunction with a pharmaceutically acceptable excipient and, in various embodiments, these formulations are unit dosage formulations. The invention provides a NASP formulation, which is orally bioavailable. Also provided are methods for utilizing the compounds and formulations of the invention to promote blood clotting in vivo as therapeutic and prophylactic agents and in vitro as an aid to studies of the blood clotting process.
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公开(公告)号：EP2809330B1
公开(公告)日：2019-06-12
申请号：EP13702878.3
申请日：2013-01-30
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： DOCKAL, Michael , SCHLEIFLINGER, Fritz , KNAPPE, Sabine , TILL, Susanne , HAI, Ton , SANDERS, Paul
IPC分类号： A61K31/795 , A61P7/04
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公开(公告)号：EP3116534B1
公开(公告)日：2019-05-29
申请号：EP15712018.9
申请日：2015-03-13
申请人： Baxalta Incorporated , Baxalta GmbH
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4.发明公开
公开(公告)号：EP3594686A3
公开(公告)日：2020-04-08
申请号：EP19174514.0
申请日：2013-08-12
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： DOCKAL, Michael , SCHEIFLINGER, Friedrich , ZHANG, Zhenqing , TILL, Susanne , KNAPPE, Sabine , SZABO, Christina
摘要： Aspects of the invention include methods for identifying one or more NASP (non-anticoagulant sulfated polysaccharide) compositions that are suitable for treating a subject having a blood coagulation disorder. In practicing methods according to certain embodiments, NASP compositions are evaluated by determining the coagulation activity and chemical makeup of the NASP composition and the molecular structure of the NASP. Systems for practicing methods of the invention as well as compositions suitable for treating a subject having a blood coagulation disorder are also described.
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5.发明授权
公开(公告)号：EP2885642B1
公开(公告)日：2019-05-15
申请号：EP13829280.0
申请日：2013-08-12
申请人： Baxalta GmbH , Baxalta Incorporated
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6.发明公开
公开(公告)号：EP3594686A2
公开(公告)日：2020-01-15
申请号：EP19174514.0
申请日：2013-08-12
申请人： Baxalta GmbH , Baxalta Incorporated
发明人： DOCKAL, Michael , SCHEIFLINGER, Friedrich , ZHANG, Zhenqing , TILL, Susanne , KNAPPE, Sabine , SZABO, Christina
摘要： Aspects of the invention include methods for identifying one or more NASP (non-anticoagulant sulfated polysaccharide) compositions that are suitable for treating a subject having a blood coagulation disorder. In practicing methods according to certain embodiments, NASP compositions are evaluated by determining the coagulation activity and chemical makeup of the NASP composition and the molecular structure of the NASP. Systems for practicing methods of the invention as well as compositions suitable for treating a subject having a blood coagulation disorder are also described.
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7.发明公开COMPOSITIONS OF HUMAN PROTHROMBIN AND ACTIVATED FACTOR X FOR IMPROVING HEMOSTASIS IN THE TREATMENT OF BLEEDING DISORDERS 审中-公开组成特征人凝血酶原和激活的因子X，以提高止血出血性疾病的治疗
公开(公告)号：EP3116534A1
公开(公告)日：2017-01-18
申请号：EP15712018.9
申请日：2015-03-13
申请人： Baxalta Incorporated , Baxalta GmbH
发明人： DOCKAL, Michael , KNAPPE, Sabine , TILL, Susanne , TURECEK, Peter, Leopold , SCHEIFLINGER, Friedrich
CPC分类号： A61K38/4833 , A61K38/4846 , A61K38/54 , C12Y304/21005 , C12Y304/21006
摘要： Disclosed herein are compositions and methods for improving hemostasis in the treatment of bleeding disorders and reversal of anticoagulant activity. Effective ratios of prothrombin (FII) and activated factor X (FXa) for the treatment of bleeding disorders that are as efficacious as FEIBA®, but require a lower concentration of FII are described herein.
摘要翻译： 公开在组合物和方法的出血性疾病和抗凝血活性的逆转治疗改善止血。 对于出血性疾病没有治疗凝血酶原（FII）和活化的因子X（XA）的有效比是作为FEIBA®一样有效，但需要FII较低浓度中有描述。
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