专利检索 ap:("Baxter International Inc" OR "Baxter Healthcare SA") AND inv:"RAY, G., Joseph" 第 1 页

1.

发明公开
NUCLEOPHILIC CATALYSTS FOR OXIME LINKAGE AND USE OF NMR ANALYSES OF THE SAME 审中-公开
标题翻译：亲核催化剂结合和使用肟的NMR分析可知：

公开(公告)号：EP2849794A1

公开(公告)日：2015-03-25

申请号：EP13724491.9

申请日：2013-05-16

申请人： Baxter International Inc , Baxter Healthcare SA

发明人： RAY, G., Joseph , ZHANG, Zhenqing , SZABO, Christina , SIEKMANN, Juergen , SCHEINECKER, Richard , HAIDER, Stefan , ROTTENSTEINER, Hanspeter , KOSMA, Paul

IPC分类号： A61K47/48

CPC分类号： A61K47/61 , A61K47/60

摘要： The invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contacting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation and analyzing the conjugation using 2D NMR analysis. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.