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1.发明公开Methods for determining active ingredients in pro-drug PEG protein conjugates with releasable PEG reagents (in vitro de-pegylation) 有权一种用于可释放PEG试剂的前药PEG-蛋白质结合物的活性成分的测定方法（体外Depegylierung）
公开(公告)号：EP2431741A1
公开(公告)日：2012-03-21
申请号：EP11009919.9
申请日：2009-10-20
发明人： Varadi, Katalin , Schrenk, Gerald , Rottensteiner, Hanspeter , Turecek, Peter , Weber, Alfred , Anderle, Heinz , Culbertson, Sean M. , Fang, Zhihao , Zappe, Harold , Zhang, Ping , Bossard, Mary J.
IPC分类号： G01N33/542 , G01N33/58 , G01N33/68 , G01N33/86
CPC分类号： G01N33/68 , G01N33/542 , G01N33/582 , G01N33/86 , G01N2333/76
摘要： The present invention relates to an in vitro method of releasing a reversibly-linked water-soluble polymer from a protein modified by the water-soluble polymer comprising the step of incubating the protein under conditions effective to release the water-soluble polymer, wherein the conditions comprise increasing free amine concentration of a buffer comprising the protein to a free amine concentration effective to release the water-soluble polymer.
摘要翻译： 本发明涉及在体外释放从由水溶性聚合物，其包含有效地释放所述水溶性聚合物的条件下孵育该蛋白质的步骤修饰的蛋白质的可逆连接的水溶性聚合物的方法，worin条件 包括增加一个缓冲器，其包括该蛋白质以游离胺的浓度有效地释放所述水溶性聚合物的游离胺的浓度。
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2.发明授权Methods for determining active ingredients in pro-drug PEG protein conjugates with releasable PEG reagents (in vitro de-pegylation) 有权一种用于可释放PEG试剂的前药PEG-蛋白质结合物的活性成分的测定方法（体外Depegylierung）
公开(公告)号：EP2431741B1
公开(公告)日：2013-08-21
申请号：EP11009919.9
申请日：2009-10-20
发明人： Varadi, Katalin , Schrenk, Gerald , Rottensteiner, Hanspeter , Turecek, Peter , Weber, Alfred , Anderle, Heinz , Culbertson, Sean M. , Fang, Zhihao , Zappe, Harold , Zhang, Ping , Bossard, Mary J.
IPC分类号： G01N33/542 , G01N33/58 , G01N33/68 , G01N33/86
CPC分类号： G01N33/68 , G01N33/542 , G01N33/582 , G01N33/86 , G01N2333/76
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3.发明公开Method and compositions for specifically detecting physiologically acceptable polymer molecules 有权方法和组合物生理上可接受的聚合物分子的特异性检测
公开(公告)号：EP2416157A3
公开(公告)日：2012-03-28
申请号：EP11177227.3
申请日：2008-12-23
发明人： Turecek, Peter , Siekmann, Jürgen , Weber, Alfred , Gritsch, Herbert , Varadi, Katalin , Vejda, Susanne
CPC分类号： G01N33/86 , G01N33/5308 , G01N2430/60
摘要： The present invention relates to a method for determining the amount of a physiologically acceptable polymer molecule bound to a protein, an antibody or other composition being capable of specifically binding to a physiologically acceptable polymer molecule, and a kit containing said antibody or composition.
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4.发明授权Method and compositions for specifically detecting physiologically acceptable polymer molecules 有权方法和组合物生理上可接受的聚合物分子的特异性检测
公开(公告)号：EP2416157B1
公开(公告)日：2014-07-30
申请号：EP11177227.3
申请日：2008-12-23
发明人： Turecek, Peter , Siekmann, Jürgen , Weber, Alfred , Gritsch, Herbert , Varadi, Katalin , Vejda, Susanne
CPC分类号： G01N33/86 , G01N33/5308 , G01N2430/60
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公开(公告)号：EP2796128A1
公开(公告)日：2014-10-29
申请号：EP14166189.2
申请日：2011-05-26
发明人： Teschner, Wolfgang , Schwarz, Hans-Peter , Madlener, Ruth , Svatos, Sonja , Pljevljakovic, Azra , Weber, Alfred
CPC分类号： C07K1/36 , A61K9/0019 , A61K9/08 , A61K35/16 , A61K38/1709 , A61K47/183 , C07K1/14 , C07K1/18 , C07K1/30 , C07K1/34 , C07K16/065
摘要： The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and/or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.
摘要翻译： 本发明提供用于降低血浆源蛋白质组合物的丝氨酸蛋白酶和/或丝氨酸蛋白酶酶原含量的新方法。 还提供了用于制备具有降低的丝氨酸蛋白酶和/或丝氨酸蛋白酶酶原含量的血浆衍生的蛋白质组合物的方法。 在其它方面中，本发明提供具有降低的丝氨酸蛋白酶和/或丝氨酸蛋白酶酶原含量的血浆衍生蛋白质的水性和冻干组合物。 还有其它方面包括用于治疗，治疗和/或预防疾病的方法，所述疾病包括施用具有降低的丝氨酸蛋白酶或丝氨酸蛋白酶酶原含量的血浆衍生的蛋白质组合物。
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6.发明公开Method and compositions for specifically detecting physiologically acceptable polymer molecules 有权用于特异性检测生理可接受的聚合物分子的方法和组合物
公开(公告)号：EP2416157A2
公开(公告)日：2012-02-08
申请号：EP11177227.3
申请日：2008-12-23
发明人： Turecek, Peter , Siekmann, Jürgen , Weber, Alfred , Gritsch, Herbert , Varadi, Katalin , Vejda, Susanne
CPC分类号： G01N33/86 , G01N33/5308 , G01N2430/60
摘要： The present invention relates to a method for determining the amount of a physiologically acceptable polymer molecule bound to a protein, an antibody or other composition being capable of specifically binding to a physiologically acceptable polymer molecule, and a kit containing said antibody or composition.
摘要翻译： 本发明涉及测定与蛋白质结合的生理上可接受的聚合物分子的量，能够特异性结合生理上可接受的聚合物分子的抗体或其它组合物的方法，以及含有所述抗体或组合物的试剂盒。
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