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1.发明授权Methods for determining active ingredients in pro-drug PEG protein conjugates with releasable PEG reagents (in vitro de-pegylation) 有权一种用于可释放PEG试剂的前药PEG-蛋白质结合物的活性成分的测定方法（体外Depegylierung）
公开(公告)号：EP2431741B1
公开(公告)日：2013-08-21
申请号：EP11009919.9
申请日：2009-10-20
发明人： Varadi, Katalin , Schrenk, Gerald , Rottensteiner, Hanspeter , Turecek, Peter , Weber, Alfred , Anderle, Heinz , Culbertson, Sean M. , Fang, Zhihao , Zappe, Harold , Zhang, Ping , Bossard, Mary J.
IPC分类号： G01N33/542 , G01N33/58 , G01N33/68 , G01N33/86
CPC分类号： G01N33/68 , G01N33/542 , G01N33/582 , G01N33/86 , G01N2333/76
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2.发明公开Methods for determining active ingredients in pro-drug PEG protein conjugates with releasable PEG reagents (in vitro de-pegylation) 有权一种用于可释放PEG试剂的前药PEG-蛋白质结合物的活性成分的测定方法（体外Depegylierung）
公开(公告)号：EP2431741A1
公开(公告)日：2012-03-21
申请号：EP11009919.9
申请日：2009-10-20
发明人： Varadi, Katalin , Schrenk, Gerald , Rottensteiner, Hanspeter , Turecek, Peter , Weber, Alfred , Anderle, Heinz , Culbertson, Sean M. , Fang, Zhihao , Zappe, Harold , Zhang, Ping , Bossard, Mary J.
IPC分类号： G01N33/542 , G01N33/58 , G01N33/68 , G01N33/86
CPC分类号： G01N33/68 , G01N33/542 , G01N33/582 , G01N33/86 , G01N2333/76
摘要： The present invention relates to an in vitro method of releasing a reversibly-linked water-soluble polymer from a protein modified by the water-soluble polymer comprising the step of incubating the protein under conditions effective to release the water-soluble polymer, wherein the conditions comprise increasing free amine concentration of a buffer comprising the protein to a free amine concentration effective to release the water-soluble polymer.
摘要翻译： 本发明涉及在体外释放从由水溶性聚合物，其包含有效地释放所述水溶性聚合物的条件下孵育该蛋白质的步骤修饰的蛋白质的可逆连接的水溶性聚合物的方法，worin条件 包括增加一个缓冲器，其包括该蛋白质以游离胺的浓度有效地释放所述水溶性聚合物的游离胺的浓度。
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公开(公告)号：EP2572732A1
公开(公告)日：2013-03-27
申请号：EP12160604.0
申请日：2004-02-26
申请人： Nektar Therapeutics
发明人： Bossard, Mary , Bentley, Michael , Zhang, Ping
IPC分类号： A61K47/48
摘要： Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.
摘要翻译： 提供因子VIII部分和一种或多种水溶性聚合物的共轭物。 通常，水溶性聚合物是聚（乙二醇）或其衍生物。 还提供了包含缀合物的组合物，制备缀合物的方法，以及向患者施用包含缀合物的组合物的方法。
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公开(公告)号：EP2898900A1
公开(公告)日：2015-07-29
申请号：EP14200659.2
申请日：2009-09-17
申请人： Nektar Therapeutics
发明人： Bossard, Mary J. , Roczniak, Steven O. , Zappe, Harold , Wang, Yujun , Zhang, Ping , Sheng, Dawei , Jude-Fishburn, C. Simone , Minamitani, Elizabeth , Moskowitz, Haim , Fry, Dennis , Ali, Cherie , Brew, Christine Taylor , Liu, Xiaofeng
IPC分类号： A61K47/48
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
摘要翻译： 本发明提供了通过共价连接水溶性低聚物进行化学修饰的肽。 本发明的缀合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的肽的特征不同的特征。
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公开(公告)号：EP2898900B1
公开(公告)日：2017-11-15
申请号：EP14200659.2
申请日：2009-09-17
申请人： Nektar Therapeutics
发明人： Bossard, Mary J. , Roczniak, Steven O. , Zappe, Harold , Wang, Yujun , Zhang, Ping , Sheng, Dawei , Jude-Fishburn, C. Simone , Minamitani, Elizabeth , Moskowitz, Haim , Fry, Dennis G. , Ali, Cherie , Brew, Christine Taylor , Liu, Xiaofeng
IPC分类号： A61K47/60
摘要： The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.
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公开(公告)号：EP2572733A1
公开(公告)日：2013-03-27
申请号：EP12160605.7
申请日：2004-02-26
申请人： Nektar Therapeutics
发明人： Bossard, Mary , Bentley, Michael , Zhang, Ping
IPC分类号： A61K47/48
摘要： Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.
摘要翻译： 提供因子VIII部分和一种或多种水溶性聚合物的偶联物。 通常，水溶性聚合物是聚（乙二醇）或其衍生物。 还提供了包含缀合物的组合物，制备缀合物的方法以及将包含缀合物的组合物给予患者的方法。
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公开(公告)号：EP2338523A1
公开(公告)日：2011-06-29
申请号：EP11152599.4
申请日：2004-02-26
申请人： Nektar Therapeutics
发明人： Bossard, Mary , Bentley, Michael , Zhang, Ping
IPC分类号： A61K47/48
摘要： Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates, and methods of administering compositions comprising the conjugates to a patient.
摘要翻译： 提供因子VIII部分和一种或多种水溶性聚合物的共轭物。 通常，水溶性聚合物是聚（乙二醇）或其衍生物。 还提供了包含缀合物的组合物，制备缀合物的方法，以及向患者施用包含缀合物的组合物的方法。
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