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1.发明授权RECOMBINANT VON WILLEBRAND FACTOR AS A MOLECULAR WEIGHT MARKER FOR MASS SPECTROMETRY ANALYSES 有权重组血管性血友病因子分子量标准进行质量分析
公开(公告)号：EP2374004B1
公开(公告)日：2012-12-05
申请号：EP09771643.5
申请日：2009-12-16
发明人： KEMPTNER, Jasmin , MARCHETTI-DESCHMANN, Martina , MUELLER, Roland , IVENS, Andreas , TURECEK, Peter , SCHWARZ, Hans-Peter , ALLMAIER, Guenter
CPC分类号： G01N33/6851 , G01N2333/755 , H01J49/164
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2.发明公开RECOMBINANT VON WILLIBRAND FACTOR AS A MOLECULAR WEIGHT MARKER FOR MASS SPECTROMETRY ANALYSES 有权重组血管性血友病因子分子量标准进行质量分析
公开(公告)号：EP2374004A1
公开(公告)日：2011-10-12
申请号：EP09771643.5
申请日：2009-12-16
发明人： KEMPTNER, Jasmin , MARCHETTI-DESCHMANN, Martina , MUELLER, Roland , IVENS, Andreas , TURECEK, Peter , SCHWARZ, Hans-Peter , ALLMAIER, Guenter
CPC分类号： G01N33/6851 , G01N2333/755 , H01J49/164
摘要： Methods for determining molecular mass of at least 150 kDa of an analyte of interest using MALDI mass spectrometry in combination with a recombinant von Willebrand factor (rVWF) molecular weight marker are disclosed. More specifically, monomeric and multimeric rVWF are used for external and internal calibration of mass spectra applied for analytes having high molecular weights above 150 kDa.
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3.发明公开METHODS OF DETERMINING POLYDISPERSITY AND/OR MOLECULAR WEIGHT DISTRIBUTION OF A POLYETHYLENE GLYCOL SAMPLE 审中-公开法确定多分散性和/或聚乙二醇探头的分子量分布
公开(公告)号：EP2366105A1
公开(公告)日：2011-09-21
申请号：EP09760672.7
申请日：2009-11-18
发明人： KEMPTNER, Jasmin , MARCHETTI-DESCHMANN, Martina , SIEKMANN, Juergen , TURECEK, Peter , SCHWARZ, Hans-Peter , ALLMAIER, Guenter
IPC分类号： G01N33/68
CPC分类号： G01N27/624
摘要： Disclosed herein are methods of determining polydispersity (PDI) and molecular mass distribution (MMD) of reactive PEG samples using mass spectrometry. More specifically, a mass spectrometry method called GEMMA is used to determine PDI and MMD of PEG samples which provides more accurate measurements for high molecular weight PEG samples than prior known MALDI-TOF analysis.
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