公开(公告)号：EP3003401B1

公开(公告)日：2020-01-15

申请号：EP14728571.2

申请日：2014-06-05

Applicant: Bayer AS

Inventor： FRENVIK, Janne Olsen ,  RYAN, Olav B ,  CUTHBERTSON, Alan

IPC: A61K51/10

公开(公告)号：EP3400084A1

公开(公告)日：2018-11-14

申请号：EP16822701.5

申请日：2016-12-29

Applicant: Bayer AS

Inventor： FRENVIK, Janne Olsen ,  RYAN, Olav B.

IPC: B01D15/36 ,  A61K51/06 ,  A61K51/12 ,  B01J39/05

CPC classification number: B01D15/362 ,  A61N2005/1021 ,  B01J39/05

Abstract: The invention provides a method for the purification of 227 Th from a mixture comprising 227 Th and 223 Ra, said method comprising: i) preparing a first solution comprising a mixture of 227 Th and 223 Ra ions dissolved in a first aqueous buffer; ii) loading said first solution onto a separation material such as a strong cation exchange resin; iii) eluting 227 Th from the separation material, whereby to generate a second solution comprising 227 Th; iv) Optionally rinsing said separation material using a first aqueous washing medium; The invention additionally provides a method for forming a radio pharmaceutical comprising complexing the purified 227 Th, the pharmaceutical product and its use in treatment of disease such as cancer and a kit for generation of such a product.

公开(公告)号：EP3400085A1

公开(公告)日：2018-11-14

申请号：EP16826752.4

申请日：2016-12-29

Applicant: Bayer AS

Inventor： MANTZILAS, Dimitrios ,  KARLSON, Jan Roger ,  ØSTBY, Judit Tjelmeland ,  FRENVIK, Janne Olsen

IPC: B01D15/36 ,  A61K51/06 ,  A61K51/12 ,  B01J41/05

CPC classification number: B01D15/363 ,  A61K51/0478 ,  A61K51/065 ,  A61K51/1093 ,  A61K51/1282 ,  B01J41/05 ,  B01J49/60

Abstract: The present invention provides a method for the purification of 227Th from a mixture comprising 227Th and 223Ra, said method comprising: i) preparing a first solution comprising a mixture of 227Th and 223Ra ions dissolved in an aqueous solution of first mineral acid; ii) loading said first solution onto a strong base anion exchange resin; iii) eluting 223Ra from said strong base anion exchange resin using a second mineral acid in an aqueous solution; iv) optionally rinsing said strong base anion exchange resin using a first aqueous medium; v) eluting 227Th from said strong base anion exchange resin using a third mineral acid in an aqueous solution whereby to generate a second solution comprising 227Th. The invention further provides a purified 227Th solution, a corresponding pharmaceutical formulation and methods of treatment of neoplastic disease.

公开(公告)号：EP3400083A1

公开(公告)日：2018-11-14

申请号：EP16822482.2

申请日：2016-12-30

Applicant: Bayer AS

Inventor： FRENVIK, Janne Olsen ,  RYAN, Olav B.

IPC: B01D15/36 ,  A61K51/06 ,  A61K51/12 ,  B01J39/05

CPC classification number: B01D15/362 ,  A61K51/1051 ,  B01J39/05 ,  C07B59/00 ,  C07B63/00

Abstract: The invention provides a method for the purification of complexed 227Th from a mixture comprising complexed 227Th and 223Ra (complexed or in solution), said method comprising: i) preparing a first solution comprising a mixture of complexed 227Th ions and 223Ra ions in a first aqueous buffer; ii) loading said first solution onto a separation material; iii) eluting complexed 227Th from said separation material whereby to generate a second solution comprising complexed 227Th; iv) Optionally rinsing said separation material using a first aqueous washing medium; The invention additionally provides a purified 227Th solution, a pharmaceutical product and its use in treatment of disease such as cancer and a kit for generation of such a product.

公开(公告)号：EP3003401A1

公开(公告)日：2016-04-13

申请号：EP14728571.2

申请日：2014-06-05

Applicant: Bayer AS

Inventor： FRENVIK, Janne Olsen ,  RYAN, Olav B ,  CUTHBERTSON, Alan

IPC: A61K51/10

Abstract: The present invention provides a method for generating a purified solution of at least one alpha-emitting radionuclide complex. The method comprises contacting a solution of the alpha-emitting radionuclide complex and at least one daughter nuclide with at least one selective binder for the daughter nuclide and subsequently separating the solution from the selective binder. The invention also provides a method for the removal of at least one daughter radionuclide from a solution comprising at least one alpha-emitting radionuclide complex. The method comprises contacting the solution with at least one selective binder for the daughter nuclide.

Abstract translation: 本发明提供了一种产生至少一种α发射放射性核素复合物的纯化溶液的方法。 该方法包括将α发射放射性核素复合物和至少一个子核素的溶液与至少一种用于子核素的选择性粘合剂接触，随后将溶液与选择性粘合剂分离。 本发明还提供一种从包含至少一种α发射放射性核素复合物的溶液中除去至少一种儿子放射性核素的方法。 该方法包括使溶液与至少一种用于子核素的选择性粘合剂接触。