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公开(公告)号：EP4259616A1
公开(公告)日：2023-10-18
申请号：EP21823604.0
申请日：2021-12-09
发明人： VAKALOPOULOS, Alexandros , COLLIN-KRÖPELIN, Marie-Pierre , ORTEGA HERNANDEZ, Nuria , DIESKAU, Andre , BOULTADAKIS-ARAPINIS, Melissa , CANDISH, Lisa , STELLFELD, Timo , MATHAR, Ilka , HOFMEISTER, Lucas, Hudson , SANDNER, Peter , WUNDER, Frank , DIETZ, Lisa , WEBSTER, Robert, Alan , SCHMECK, Carsten
IPC分类号： C07D401/04 , C07D401/14 , A61P9/10 , A61K31/496
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公开(公告)号：EP1368335A2
公开(公告)日：2003-12-10
申请号：EP02701292.1
申请日：2002-02-22
发明人： ALONSO-ALIJA, Cristina , HÄRTER, Michael , HAHN, Michael , PERNERSTORFER, Josef , WEIGAND, Stefan , STASCH, Johannes-Peter , WUNDER, Frank
IPC分类号： C07D333/20 , C07C229/38 , C07D213/65 , A61P9/00 , A61K31/381 , A61K31/197 , A61K31/44
CPC分类号： C07C229/38 , C07C2602/10 , C07D213/65 , C07D333/20
摘要： The invention relates to the use of compounds of formula (I) and of their salts and stereoisomers for producing medicaments used in the treatment of cardiovascular diseases.
摘要翻译： 本发明涉及式（I）化合物及其盐和立体异构体用于制备用于治疗心血管疾病的药物的用途。
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3.发明公开SEITENKETTENHALOGENIERTE AMINODICARBONSAUREDERIVATE ALS ARZNEIMITTEL ZUR BEHANDLUNG VON HERZ-KREISLAUF-ERKRANKUNGEN 有权侧链卤化AMINODICARBONSAUREDERIVATE AS药物用于治疗心血管疾病的治疗
公开(公告)号：EP1368301A1
公开(公告)日：2003-12-10
申请号：EP02716805.3
申请日：2002-02-22
发明人： HÄRTER, Michael , HAHN, Michael , HIRTH-DIETRICH, Claudia , KNORR, Andreas , STAHL, Elke , STASCH, Johannes, Peter , WUNDER, Frank
IPC分类号： C07C229/38 , A61K31/195 , A61P9/00
CPC分类号： C07C229/38
摘要： The invention relates to compounds of formula (I), to a method for their production and to the use thereof as medicaments.
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4.发明公开NEUARTIGE AMINODICARBONSÄUREDERIVATE MIT PHARMAZEUTISCHEN EIGENSCHAFTEN 有权与制药特性的新AMINODICARBONSÄUREDERIVATE
公开(公告)号：EP1216225A2
公开(公告)日：2002-06-26
申请号：EP00958516.7
申请日：2000-08-31
发明人： ALONSO-ALIJA, Cristina , HEIL, Markus , FLUBACHER, Dietmar , NAAB, Paul , PERNERSTORFER, Josef , STASCH, Johannes-Peter , WUNDER, Frank , DEMBOWSKY, Klaus , PERZBORN, Elisabeth , STAHL, Elke
IPC分类号： C07C229/38 , C07D239/30 , C07D277/24 , C07D271/04 , C07D285/06 , A61K31/195 , A61K31/24 , A61K31/505 , A61K31/426 , A61K31/33
CPC分类号： C07D239/30 , C07C229/38 , C07C233/25 , C07C235/56 , C07C237/12 , C07C255/54 , C07C275/24 , C07C317/18 , C07C323/19 , C07C2601/14 , C07C2602/10 , C07D239/38 , C07D271/06 , C07D277/24 , C07D285/06 , C07D295/088 , C07D333/16
摘要： The invention relates to compounds of formula (I) as well as the salts and stereoisomers thereof used in the production of medicaments for the treatment of cardiovascular diseases.
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公开(公告)号：EP4259617A1
公开(公告)日：2023-10-18
申请号：EP21823605.7
申请日：2021-12-09
发明人： VAKALOPOULOS, Alexandros , COLLIN-KRÖPELIN, Marie-Pierre , ORTEGA HERNANDEZ, Nuria , DIESKAU, Andre , BOULTADAKIS-ARAPINIS, Melissa , CANDISH, Lisa , STELLFELD, Timo , MATHAR, Ilka , HOFMEISTER, Lucas, Hudson , SANDNER, Peter , WUNDER, Frank , DIETZ, Lisa , WEBSTER, Robert, Alan , SCHMECK, Carsten , MONDRITZKI, Thomas
IPC分类号： C07D401/04 , A61P7/00 , A61P9/00 , A61P11/00 , A61P13/12 , A61K31/496
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公开(公告)号：EP3773901A1
公开(公告)日：2021-02-17
申请号：EP19716169.8
申请日：2019-04-10
发明人： MAYER-BARTSCHMID, Anke , BROCKSCHNIEDER, Damian , GEERTZ, Marcel , GREVEN, Simone , HOFMEISTER, Lucas, Hudson , JÖRISSEN, Hannah , MAHLERT, Christoph , MARQUARDT, Tobias , MATHAR, Ilka , MONDRITZKI, Thomas , NOACK, Claudia , TEBBE, Jan , WALSH, Stuart , WEBER, Ernst , WILMEN, Andreas , WUNDER, Frank
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公开(公告)号：EP3700903A1
公开(公告)日：2020-09-02
申请号：EP18785687.7
申请日：2018-10-18
发明人： MEIBOM, Daniel , MEYER, Jutta , COLLINS, Karl , ORTEGA HERNANDEZ, Nuria , STAMPFUSS, Jan , WUNDER, Frank , FREUDENBERGER, Till , MONDRITZKI, Thomas , SCHEERER, Nina Alexandra , LEINEWEBER, Kirsten , SCHAMBERGER, Jens , STRAUB, Alexander , GERICKE Kersten, Matthias , KROH, Walter , LOBELL, Mario , MÜNTER, Klaus
IPC分类号： C07D471/04 , C07D519/00 , A61P9/00 , A61K31/437
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公开(公告)号：EP1368302A1
公开(公告)日：2003-12-10
申请号：EP02718141.1
申请日：2002-02-18
发明人： HÄRTER, Michael , HAHN, Michael , HIRTH-DIETRICH, Claudia , KNORR, Andreas , STAHL, Elke , STASCH, Johannes-Peter , WUNDER, Frank
IPC分类号： C07C229/38 , A61K31/195 , A61P9/00
CPC分类号： C07C229/38 , C07C2601/14
摘要： The invention relates to compounds of formula (I), to a method for their production and to their use as medicaments.
摘要翻译： 本发明涉及治疗心力衰竭，血栓栓塞性疾病和肺纤维化的方法，包括施用有效量的式（I）化合物，其中若干变量如说明书和权利要求中所定义。
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公开(公告)号：EP1343786A1
公开(公告)日：2003-09-17
申请号：EP01997489.8
申请日：2001-11-09
发明人： STASCH, Johannes-Peter , FEURER, Achim , WEIGAND, Stefan , STAHL, Elke , FLUBACHER, Dietmar , ALONSO-ALIJA, Cristina , WUNDER, Frank , LANG, Dieter , DEMBOWSKY, Klaus , STRAUB, Alexander , PERZBORN, Elisabeth
IPC分类号： C07D471/04 , A61K31/415 , A61P9/00
CPC分类号： C07D471/04 , A61K31/505 , A61K45/06 , A61K2300/00
摘要： The invention relates to novel pyrazolopyridine derivatives of the formula (I), wherein R1 represents 4-pyridinyl or 3-pyridinyl; R2 represents H, NH¿2? or halogen, and to the salts, isomers and hydrates thereof as stimulators of the soluble guanylate cyclase and for the use as agents for treating cardiovascular diseases, hypertonia, thromboembolic diseases and ischemias, sexual dysfunction or inflammations and for treating diseases of the central nervous system.
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公开(公告)号：EP1339716A1
公开(公告)日：2003-09-03
申请号：EP01997487.2
申请日：2001-11-09
发明人： STASCH, Johannes-Peter , FEURER, Achim , WEIGAND, Stefan , STAHL, Elke , FLUBACHER, Dietmar , ALONSO-ALIJA, Cristina , WUNDER, Frank , LANG, Dieter , DEMBOWSKY, Klaus , STRAUB, Alexander , PERZBORN, Elisabeth
IPC分类号： C07D471/04 , A61K31/437 , A61P9/00 , A61P15/00 , A61P25/00
CPC分类号： C07D471/04
摘要： The invention relates to novel pyrazolopyridine derivatives of formula (I) wherein R1 represents NH¿2? or NHCO-C1-6-alkyl, and R?2¿ represents a radical of formula R3NCOR4 which is bonded to the radical of the molecule by means of the nitrogen atom, R?3 and R4¿ forming, together with the amide group to which they are bonded, a five to six-membered heterocycle which can be saturated or partially unsaturated, can optionally contain another heteroatom from the group N, O, S and can comprise between one and five other substituents from the group oxo, C1-6 alkyl, hydroxy, hydroxy-C¿1-6?-alkyl, halogen, or can be anellated to a C6-10 aryl ring or a C3-8 cycloalkyl ring in which optionally two carbon atoms are bonded to each other by means of an oxygen atom. The invention also relates to salts, isomers and hydrates of said derivatives, in the form of stimulators of soluble guanylate cyclase and as agents for treating cardiovascular diseases, hypertonia, thrombo-embolic diseases and ischaemia, sexual dysfunction, inflammations, and diseases of the central nervous system.
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