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公开(公告)号：EP1501795A1
公开(公告)日：2005-02-02
申请号：EP03720461.7
申请日：2003-04-14
发明人： BRUNNER, Nina , FREIBERG, Christoph , LAMPE, Thomas , NEWTON, Ben , OTTENEDER, Michael , PERNERSTORFER, Josef , POHLMANN, Jens , SCHIFFER, Guido , SHIMADA, Mitsuyuki , SVENSTRUP, Niels , ENDERMANN, Rainer , NELL, Peter
IPC分类号： C07D207/40 , C07D401/12 , C07D405/12 , C07D409/12 , A61K31/4015 , A61P31/04
CPC分类号： C07D207/40 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12
摘要： The invention relates to compounds, methods for the production thereof, pharmaceutical compositions containing said compounds and the use thereof in the treatment and/or prophylaxis of diseases, especially bacterial diseases, in human beings and animals.
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2.发明公开
公开(公告)号：EP1324987A1
公开(公告)日：2003-07-09
申请号：EP01978337.2
申请日：2001-09-05
发明人： WOLTERING, Michael , HANING, Helmut , SCHMIDT, Gunter , PERNERSTORFER, Josef , BISCHOFF, Hilmar , KRETSCHMER, Axel , VÖHRINGER, Verena , FAESTE, Christiane
IPC分类号： C07D231/56 , A61K31/416
CPC分类号： A61K45/06 , C07D231/56
摘要： The invention relates to novel indazole derivatives of formula (I), in which Z represents O, S, CH2, CHF or CF2, and wherein R1-R7 have meanings as cited in Claim No. 1. The inventive indazole derivatives have an action similar to that of a thyroid hormone. The invention also relates to a method for producing said indazole derivatives, and to their use in medicaments.
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3.发明公开PROPIONSÄUREDERIVATE MIT PPAR-ALPHA AKTIVIERENDEN EIGENSCHAFTEN 审中-公开PROPIONSÄUREDERIVATEMIT PPAR-ALPHA AKTIVIERENDEN EIGENSCHAFTEN
公开(公告)号：EP1328508A2
公开(公告)日：2003-07-23
申请号：EP01974287.3
申请日：2001-09-24
发明人： URBAHNS, Klaus , WOLTERING, Michael , NIKOLIC, Susanne , PERNERSTORFER, Josef , HINZEN, Berthold , DITTRICH-WENGENROTH, Elke , BISCHOFF, Hilmar , HIRTH-DIETRICH, Claudia , LUSTIG, Klemens
IPC分类号： C07C237/04 , C07C333/20 , C07C323/52 , C07C317/18 , C07D307/52 , C07D263/32 , A61K31/165 , A61K31/421 , A61K31/381 , A61P9/10 , C07C229/36 , C07C229/14
CPC分类号： C07D263/32 , C07C229/18 , C07C229/34 , C07C237/04 , C07C317/28 , C07C323/52 , C07C2601/14 , C07D307/52 , C07D333/20
摘要： The invention relates to the PPAR-alpha activating compounds of general formula (I), for treating for example coronary heart diseases, and to a method for producing said compounds, wherein R?1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13¿, A and X are defined as in claim 1.
摘要翻译： 本发明涉及用于治疗例如冠心病的新颖有效的PPAR-α活化化合物及其制备方法。
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公开(公告)号：EP1286957A1
公开(公告)日：2003-03-05
申请号：EP01938186.2
申请日：2001-05-07
发明人： HANING, Helmut , SCHMIDT, Gunter , PERNERSTORFER, Josef , BISCHOFF, Hilmar , SCHMECK, Carsten , VÖHRINGER, Verena , WOLTERING, Michael , KRETSCHMER, Axel , FAESTE, Christiane
IPC分类号： C07C271/28 , A61K31/325 , A61P5/16
CPC分类号： C07C271/28 , A61K31/325 , A61K45/06 , A61K2300/00
摘要： The invention relates to novel diphenylmethane derivatives, a method for production thereof and use thereof as a medicament, in particular for the indications of arteriosclerosis, and hypercholesterolaemia.
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公开(公告)号：EP1307426A1
公开(公告)日：2003-05-07
申请号：EP01956554.8
申请日：2001-07-23
发明人： HANING, Helmut , PERNERSTORFER, Josef , SCHMIDT, Gunter , WOLTERING, Michael , BISCHOFF, Hilmar , VÖHRINGER, Verena , KRETSCHMER, Axel , FAESTE, Christiane
IPC分类号： C07C235/80 , C07C235/24 , C07C275/36 , C07D295/027 , C07D307/52 , C07D307/14 , C07D223/10 , C07D213/38 , C07D211/58 , C07C233/25 , C07D333/38 , C07C233/75 , C07C233/74 , C07D311/24 , A61P5/16
CPC分类号： C07D295/215 , C07C233/25 , C07C233/26 , C07C233/29 , C07C233/56 , C07C233/60 , C07C233/73 , C07C233/75 , C07C235/16 , C07C235/24 , C07C235/60 , C07C235/62 , C07C237/30 , C07C271/28 , C07C275/36 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D213/38 , C07D223/10 , C07D307/14 , C07D307/52 , C07D311/24 , C07D333/38
摘要： The invention relates to novel amino diphenyl ethers and amido diphenyl ethers, to methods for the production thereof, and to their use in medicaments, especially for the indications of arteriosclerosis and hypercholesterolemia.
摘要翻译： 本发明涉及新的氨基和酰氨基二苯基醚，其制备方法及其在药物中的用途，特别是用于动脉硬化和高胆固醇血症的适应症。
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公开(公告)号：EP1148879A2
公开(公告)日：2001-10-31
申请号：EP00909096.0
申请日：2000-01-24
发明人： STOLTEFUSS, Jürgen , BRÄUNLICH, Gabriele , HINZEN, Berthold , KRÄMER, Thomas , PERNERSTORFER, Josef , STÜDEMANN, Thomas , NIELSCH, Ulrich , BECHEM, Martin , LOHRMANN, Emanuel , GERDES, Christoph , SPERZEL, Michael , LUSTIG, Klemens , MAYR, Lorenz
IPC分类号： A61K31/4155 , A61K31/443 , A61P7/06 , C07D231/12
CPC分类号： C07D231/12 , A61K31/415 , C07D401/04 , C07D409/04
摘要： The present invention relates to novel and known pyrazole carboxamides of general formulae (I and Ia), whereby A, A', D, D', E, E', G, G', R1, R'1, R2 and L have the meaning as given in the description. The invention also relates to the production of pyrazole carboxamides by means of solid phase chemistry or novel pyrazole carboxamides. The pyrazole carboxamides are used as medicaments, especially (oral) medicaments for the treatment of anaemias. Said carboxamides stimulate the EPO production (erythropoesis) and can be used with own blood donors.
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公开(公告)号：EP1368300A1
公开(公告)日：2003-12-10
申请号：EP02703602.9
申请日：2002-02-25
发明人： ALONSO-ALIJA, Cristina , HÄRTER, Michael , HAHN, Michael , PERNERSTORFER, Josef , WEIGAND, Stefan , STASCH, Johannes-Peter , WUNDER, Frank
IPC分类号： C07C229/38 , C07C323/19 , A61K31/195 , A61P7/00 , A61P9/00
CPC分类号： C07C229/38 , C07C323/19 , C07C2601/14
摘要： The invention relates to compounds of formula (I), to salts and stereoisomers thereof, to their production and to their use for producing medicaments used for treating cardiovascular diseases.
摘要翻译： 本发明涉及式（I）化合物，其盐和立体异构体对其生产及其用于制备用于治疗心血管疾病的药物的用途。
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8.发明公开
公开(公告)号：EP1339670A1
公开(公告)日：2003-09-03
申请号：EP01994647.4
申请日：2001-11-12
发明人： RÖHRIG, Susanne , STOLLE, Andreas , CASTRO-PALOMINO, Julio, C. , HANING, Helmut , HANDKE-ERGÜDEN, Gabriele , DAVIU-FOLGUERA, Noemi , PAULSEN, Holger , PERNERSTORFER, Josef , WIRTZ, Stephan-Nicholas , STEINHAGEN, Henning , THIELEMANN, Wolfgang , BISCHOFF, Erwin , EBBINGHAUS-KINTSCHER, Ulrich , ELLINGHAUS, Peter , HÜTTER, Joachim , KRAHN, Thomas , WUNDER, Frank , LUSTIG, Klemens , SCHUHMACHER, Joachim
IPC分类号： C07C237/24 , C07D295/20 , A61P9/00 , C07C271/58 , C07C271/54 , C07C271/44 , C07C271/24 , C07C271/56 , C07C311/16 , C07C311/19 , C07C233/65 , C07C233/73 , C07C233/78 , C07C275/26 , C07C275/42 , C07C235/40 , C07C235/82 , C07D213/75
CPC分类号： C07D213/30 , C07C233/65 , C07C233/73 , C07C233/78 , C07C235/40 , C07C235/82 , C07C237/24 , C07C271/24 , C07C271/44 , C07C271/54 , C07C271/56 , C07C271/58 , C07C275/26 , C07C275/42 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/46 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D207/12 , C07D207/16 , C07D211/22 , C07D211/58 , C07D213/40 , C07D213/64 , C07D213/68 , C07D215/08 , C07D217/04 , C07D217/06 , C07D223/12 , C07D237/16 , C07D239/34 , C07D275/03 , C07D277/24 , C07D277/28 , C07D277/34 , C07D277/46 , C07D285/08 , C07D295/096 , C07D295/155 , C07D295/215 , C07D307/14 , C07D307/52 , C07D307/68 , C07D311/64 , C07D317/58 , C07D317/64 , C07D333/20 , C07D417/12 , C07D471/04
摘要： The invention relates to substituted cyclohexane derivates of formula (I), a method for the production thereof and the use thereof in medicaments, particularly for preventing and/or treating cardiovascular diseases, diseases of the urogenital tract and cerebrovascular diseases.
摘要翻译： 本发明涉及substituiertem式（I）的环己烷衍生物，其制造和在药物中的用途的方法，特别是用于预防和/或治疗心血管疾病，泌尿生殖道和脑血管疾病的疾病。
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9.发明公开INDOLE ZUR BEHANDLUNG VON KRANKHEITEN DIE MIT SCHILDDRÜSENHORMONEN BEHANDELN WERDEN KÖNNEN 审中-公开FOR疾病与甲状腺激素治疗的治疗吲哚可
公开(公告)号：EP1268422A1
公开(公告)日：2003-01-02
申请号：EP01936103.9
申请日：2001-03-19
发明人： HANING, Helmut , SCHMIDT, Gunter , PERNERSTORFER, Josef , SCHMECK, Carsten , MÜLLER, Ulrich , BISCHOFF, Hilmar , VÖHRINGER, Verena , REINEMER, Peter , APELER, Heiner , SCHMIDT, Delf , JONGHAUS, Willi , FAESTE, Christiane , ZOCHE, Martin , HAUSWALD, Markus , WOLTERING, Michael , KRETSCHMER, Axel
IPC分类号： C07D209/40 , A61K31/40 , C07D401/12 , A61K31/44 , C07D409/12 , A61K31/535
CPC分类号： C07D401/04 , C07D209/08 , C07D209/18 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The invention relates to novel indole derivatives, to methods for the production thereof and to their use in medicaments.
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10.发明公开
公开(公告)号：EP1150958A1
公开(公告)日：2001-11-07
申请号：EP00910605.5
申请日：2000-01-24
发明人： STOLTEFUSS, Jürgen , BRÄUNLICH, Gabriele , HINZEN, Berthold , KRÄMER, Thomas , PERNERSTORFER, Josef , STÜDEMANN, Thomas , NIELSCH, Ulrich , BECHEM, Martin , LOHRMANN, Emanuel , GERDES, Christoph , SPERZEL, Michael , LUSTIG, Klemens , MAYR, Lorenz
IPC分类号： C07D231/12 , C07D409/04 , A61K31/415 , A61P7/06 , C07D401/04 , C07D405/04
CPC分类号： C07D231/12 , C07D401/04 , C07D405/04 , C07D409/04
摘要： The invention relates to methods for the production of substituted pyrazole carboxylic acids of general formula (I). The key step is cyclization with hydrazines followed by saponification. The substituted pyrazole carboxylic acids are used as medicaments, especially as medicaments in the treatment and prophylaxis of anaemias.
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