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公开(公告)号：EP4065584A1
公开(公告)日：2022-10-05
申请号：EP20808437.6
申请日：2020-11-24
发明人： SCHMEES, Norbert , WORTMANN, Lars , KIRCHHOFF, Dennis , NGUYEN, Thi, Thanh, Uyen , WERBECK, Nicolas , BÖMER, Ulf , PETERSEN, Kirstin , KOBER, Christina , STÖCKIGT, Detlef , LECHNER, Christian , OFFRINGA, Rienk
IPC分类号： C07D487/10 , A61K31/4375 , A61P9/00 , A61P31/12 , A61P35/00
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公开(公告)号：EP4065574A1
公开(公告)日：2022-10-05
申请号：EP20808438.4
申请日：2020-11-24
发明人： SCHMEES, Norbert , WORTMANN, Lars , KIRCHHOFF, Dennis , NGUYEN, Thi, Thanh, Uyen , WERBECK, Nicolas , BÖMER, Ulf , PETERSEN, Kirstin , KOBER, Christina , STÖCKIGT, Detlef , LECHNER, Christian , MEIER, Robin, Michael , HERBERT, Simon, Anthony , KERSCHGENS, Isabel, Patrizia , KOSEMUND, Dirk , OFFRINGA, Rienk , GREES, Mareike
IPC分类号： C07D403/04 , A61K31/4353 , A61P35/00
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公开(公告)号：EP4065570A1
公开(公告)日：2022-10-05
申请号：EP20808436.8
申请日：2020-11-24
发明人： SCHMEES, Norbert , WORTMANN, Lars , KIRCHHOFF, Dennis , NGUYEN, Thi, Thanh, Uyen , WERBECK, Nicolas , BÖMER, Ulf , PETERSEN, Kirstin , KOBER, Christina , STÖCKIGT, Detlef , LECHNER, Christian , MEIER, Robin, Michael , HERBERT, Simon, Anthony , KERSCHGENS, Isabel, Patrizia , KOSEMUND, Dirk , LEFRANC, Julien , OFFRINGA, Rienk
IPC分类号： C07D401/04 , C07D403/14 , C07D405/14 , A61K31/4709 , A61P31/12 , A61P9/00 , A61P35/00
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公开(公告)号：EP4139287A1
公开(公告)日：2023-03-01
申请号：EP21720251.4
申请日：2021-04-20
发明人： SCHMEES, Norbert , ROEHN, Ulrike , KIRCHHOFF, Dennis , PETERSEN, Kirstin , NGUYEN, Thi, Thanh, Uyen , GREES, Mareike , WERBECK, Nicolas , BOEMER, Ulf , BADER, Benjamin , STOECKIGT, Detlef , OFFRINGA, Rienk , LINK, Corinna , TESTOLIN, Giambattista , NOWAK-REPPEL, Katrin
IPC分类号： C07D277/38 , C07D417/06 , C07D417/10 , A61K31/426 , A61K31/4439 , A61P37/06
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公开(公告)号：EP4139286A1
公开(公告)日：2023-03-01
申请号：EP21720249.8
申请日：2021-04-20
发明人： SCHMEES, Norbert , ROEHN, Ulrike , KIRCHHOFF, Dennis , PETERSEN, Kirstin , NGUYEN, Thi, Thanh, Uyen , GREES, Mareike , WERBECK, Nicolas , BOEMER, Ulf , BADER, Benjamin , STOECKIGT, Detlef , KOSEMUND, Dirk , OFFRINGA, Rienk , LINK, Corinna , NOWAK-REPPEL, Katrin
IPC分类号： C07D277/38 , C07D417/06 , C07D417/10 , A61K31/426 , A61K31/4439 , A61P37/06
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公开(公告)号：EP3558388A1
公开(公告)日：2019-10-30
申请号：EP17837949.1
申请日：2017-12-14
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7.发明公开ANTIKÖRPER-WIRKSTOFF-KONJUGATE (ADCS) VON KSP-INHIBITOREN MIT ANTI-CD123-ANTIKÖRPERN 审中-公开具有抗CD123抗体的KSP抑制剂的抗体 - 活性偶联物（ADCS）
公开(公告)号：EP3313524A1
公开(公告)日：2018-05-02
申请号：EP16736011.4
申请日：2016-06-20
发明人： LERCHEN, Hans-Georg , REBSTOCK, Anne-Sophie , CANCHO-GRANDE, Yolanda , WITTROCK, Sven , STELTE-LUDWIG, Beatrix , MAHLERT, Christoph , GREVEN, Simone , MÄRSCH, Stephan , KIRCHHOFF, Dennis
IPC分类号： A61P35/00
CPC分类号： A61K47/6803 , A61K31/40 , A61K31/4025 , A61K47/6849 , A61K47/6851 , A61K2039/505 , A61K2039/572 , A61P35/00 , C07K16/2866 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention relates to novel antibody drug conjugates (ADCs), active metabolites of said ADCs, to methods for producing said ADCs, to the use of said ADCs for the treatment and/or prevention of diseases, and to the use of said ADCs for the production of medicaments for the treatment and/or prevention of diseases, in particular hyperproliferative and angiogenic diseases, such as cancer diseases. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
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公开(公告)号：EP3558387A1
公开(公告)日：2019-10-30
申请号：EP17837872.5
申请日：2017-12-18
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9.发明公开
公开(公告)号：EP3471776A1
公开(公告)日：2019-04-24
申请号：EP17730108.2
申请日：2017-06-08
发明人： LERCHEN, Hans-Georg , REBSTOCK, Anne-Sophie , CANCHOGRANDE, Yolanda , WITTROCK, Sven , STELTE-LUDWIG, Beatrix , KIRCHHOFF, Dennis , MAHLERT, Christoph , GREVEN, Simone , MÄRSCH, Stephan
IPC分类号： A61K47/68 , A61P35/00 , C07D207/335 , C07D233/64 , C07K16/28 , C07K16/30
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10.发明公开
公开(公告)号：EP3919518A1
公开(公告)日：2021-12-08
申请号：EP21186955.7
申请日：2017-06-08
发明人： LERCHEN, Hans-Georg , REBSTOCK, Anne-Sophie , CANCHOGRANDE, Yolanda , WITTROCK, Sven , STELTE-LUDWIG, Beatrix , KIRCHHOFF, Dennis , MAHLERT, Christoph , GREVEN, Simone , MÄRSCH, Stephan
IPC分类号： C07K16/28 , A61K47/68 , A61P35/00 , C07D207/335 , C07D233/64
摘要： The invention relates to specific Antibody-Drug-Conjugates (ADCs) with KSP inhibitors and anti-CD 123-antibodies, to the use of these conjugates for the treatment and/or prophylaxis of diseases and to the use of these conjugates for preparing medicaments for treatment and/or prevention of diseases, in particular hyperproliferative and/or angiogenic disorders such as, for example, cancer diseases. Such treatments can be carried out as monotherapy or else in combination with other medicaments or further therapeutic measures.
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