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1.发明授权
公开(公告)号：EP1303286B1
公开(公告)日：2006-04-26
申请号：EP01949489.7
申请日：2001-07-11
申请人： Bayer HealthCare AG
发明人： WEBER, Olaf , SCHLAPP, Tobias , SIEGLING, Angela , KNORR, Andreas , HIRTH-DIETRICH, Claudia , THEISS, Gudrun , VOLK, Hans-Dieter, Prof.Dr.
CPC分类号： A61K35/76 , C12N2710/24232
摘要： The invention relates to the use of strains of the parapox ovis virus as immune therapeutics for infectious or non-infectious immune weaknesses, as well as the use of strains of said virus for treating tumour diseases and viral infections. The invention also relates to the use of strains of the parapox ovis virus for producing pharmaceuticals for both humans and animals.
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2.发明授权ORGAN-, GEWEBS- UND ZELLSPEZIFISCHES IMMUNTHERAPEUTIKUM FÜR CHRONISCHE VIRALE INFEKTIONEN, SOWIE ENTZÜNDLICHE, DEGENERATIVE UND PROLIFERATIVE ERKRANKUNGEN INSBESONDERE DER LEBER SOWIE KREBS AUF DER BASIS VON REKOMBINANTEM PARAPOXVIRUS 有权器官，组织和细胞特异性免疫治疗剂，慢性病毒感染，炎性，退行性和增殖性疾病包括肝脏癌症和对重组副痘病毒的BASIS
公开(公告)号：EP1181381B1
公开(公告)日：2004-10-20
申请号：EP00925261.0
申请日：2000-05-04
申请人： Bayer HealthCare AG
发明人： WEBER, Olaf , SIEGLING, Angela , SCHLAPP, Tobias
CPC分类号： C12N15/86 , C12N15/87 , C12N2710/24243
摘要： The invention relates to the production and use of organ, tissue and/or cell-specific, recombinant parapox virus ovis as a targeted immuno-therapeutic which is pathogen and organ-specific for treating chronic viral infections and inflammatory, degenerative, proliferative diseases, in particular of the liver and for treating cancer.
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3.发明公开RECOMBINANT PROTEINS OF PARAPOXVIRUS OVIS AND PHARMACEUTICAL COMPOSITIONS THEREFROM 审中-公开重组蛋白羊副痘病毒及其药物组合物
公开(公告)号：EP1575614A1
公开(公告)日：2005-09-21
申请号：EP02808241.0
申请日：2002-12-17
申请人： Bayer HealthCare AG
发明人： WEBER, Olaf,c/o Bayer Corp. , FRIEDERICHS, Sonja Maria , SIEGLING, Angela , SCHLAPP, Tobias , MERCER, Andrew Allan , FLEMING, Stephen Bruce , VOLK, Hans-Dieter
IPC分类号： A61K39/275 , A61K48/00 , C07K14/065 , C12N5/10 , C12N15/39 , C12N15/863
CPC分类号： C12N15/86 , A61K38/00 , A61K2039/525 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2710/24143 , C12N2710/24221 , C12N2710/24222 , C12N2710/24233 , C12N2710/24243
摘要： The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
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公开(公告)号：EP1392268A2
公开(公告)日：2004-03-03
申请号：EP01985905.7
申请日：2001-12-19
申请人： Bayer HealthCare AG
CPC分类号： A61K31/785
摘要： The invention relates to a medicament containing a polyamine as an active substance, in addition to the use of a polyamine for producing immunostimulant medicaments or medicaments for the treatment and/or prophylaxis of various illnesses in humans and animals.
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公开(公告)号：EP1511512A1
公开(公告)日：2005-03-09
申请号：EP03730100.9
申请日：2003-05-23
申请人： Bayer HealthCare AG
IPC分类号： A61K39/275 , A61P31/04 , A61P31/06
CPC分类号： A61K35/76 , A61K38/162 , C12N2710/24232
摘要： The present invention related to use of Parapoxvirus preparations for the treatment of conditions related to infections with strictly intracellular bacteria
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