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1.发明公开USE OF PARAPOX B2L PROTEIN TO TREAT CANCER AND MODIFY IMMUNE RESPONSES 审中-公开Parapox B2L蛋白对癌症免疫反应的治疗和改性用
公开(公告)号：EP1499355A4
公开(公告)日：2005-10-05
申请号：EP02789997
申请日：2002-12-06
IPC分类号： A61K39/275 , A61K39/39 , A61K48/00 , C07K14/065 , C12Q1/02 , G01N33/569 , A61K45/00 , G01N33/566
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/53 , A61K2039/54 , A61K2039/55516 , C07K2319/21 , C07K2319/40 , C12N2710/24222 , C12N2710/24233
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2.发明授权PARAPOCKENVIREN, DIE FREMD-DNA ENTHALTEN, IHRE HERSTELLUNG UND IHRE VERWENDUNG IN IMPFSTOFFEN 失效PARA痘病毒，外国DNA包含其疫苗生产和使用
公开(公告)号：EP0886679B1
公开(公告)日：2007-06-06
申请号：EP97904453.4
申请日：1997-02-17
申请人： Bayer HealthCare AG
IPC分类号： C12N15/86 , C12N15/39 , C07K14/065 , C12N7/01 , A61K39/275 , C12N15/11
CPC分类号： C12N15/86 , A61K39/00 , C07K14/005 , C12N2710/24222 , C12N2710/24243
摘要： The invention concerns recombinantly produced parapoxviruses which carry in their genome deletions or insertions in the form of foreign hereditary information and contain other hereditary information. The invention also concerns the production of such constructs and their use in vaccines.
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3.发明公开RECOMBINANT PROTEINS OF PARAPOXVIRUS OVIS AND PHARMACEUTICAL COMPOSITIONS THEREFROM 审中-公开重组蛋白羊副痘病毒及其药物组合物
公开(公告)号：EP1575614A1
公开(公告)日：2005-09-21
申请号：EP02808241.0
申请日：2002-12-17
申请人： Bayer HealthCare AG
发明人： WEBER, Olaf,c/o Bayer Corp. , FRIEDERICHS, Sonja Maria , SIEGLING, Angela , SCHLAPP, Tobias , MERCER, Andrew Allan , FLEMING, Stephen Bruce , VOLK, Hans-Dieter
IPC分类号： A61K39/275 , A61K48/00 , C07K14/065 , C12N5/10 , C12N15/39 , C12N15/863
CPC分类号： C12N15/86 , A61K38/00 , A61K2039/525 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2710/24143 , C12N2710/24221 , C12N2710/24222 , C12N2710/24233 , C12N2710/24243
摘要： The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
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4.发明公开USE OF PARAPOX B2L PROTEIN TO TREAT CANCER AND MODIFY IMMUNE RESPONSES 审中-公开使用本Parapox B2L蛋白用于产生免疫应答的抗原内源增强药物。
公开(公告)号：EP1499355A2
公开(公告)日：2005-01-26
申请号：EP02789997.0
申请日：2002-12-06
IPC分类号： A61K45/00 , A61K39/275 , A61K48/00 , C12Q1/02 , G01N33/53 , G01N33/566
CPC分类号： C07K14/005 , A61K39/39 , A61K2039/53 , A61K2039/54 , A61K2039/55516 , C07K2319/21 , C07K2319/40 , C12N2710/24222 , C12N2710/24233
摘要： A purified Parapoxvirus ovis envelope protein termed 'B2L' can be used as a monotherapeutic agent. B2L protein also can be used in screening methods to identify potential therapeutic agents for modulating a subject's immune response to the B2L protein.
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5.发明公开Recombinant proteins of Parapoxvirus ovis and pharmaceutical compositions therefrom 有权Rekombinante Proteine des Parapoxivirus Ovis und pharmazeutische Zusammensetzungen daraus
公开(公告)号：EP2647645A1
公开(公告)日：2013-10-09
申请号：EP13175420.2
申请日：2002-12-17
IPC分类号： C07K14/065 , C12N15/863 , A61K39/275 , A61P31/20 , A61P37/00
CPC分类号： C12N15/86 , A61K38/00 , A61K2039/525 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2710/24143 , C12N2710/24221 , C12N2710/24222 , C12N2710/24233 , C12N2710/24243
摘要： The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
摘要翻译： 本发明涉及编码PPVO病毒基因组的多核苷酸，编码PPVO基因组的多核苷酸的片段和编码PPVO病毒基因组的个体开放阅读框（ORF）的多核苷酸。 本发明还涉及由上述多核苷酸表达的重组蛋白和所述重组蛋白的片段，以及所述重组蛋白或片段用于制备药物组合物的用途。
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6.发明公开VASCULAR ENDOTHELIAL GROWTH FACTOR-LIKE PROTEIN FROM ORF VIRUS NZ2 BINDS AND ACTIVATES MAMMALIAN VEGF RECEPTOR-2 有权对血管内皮生长因子相关蛋白FROM ORF病毒N22 TIES并启用所述哺乳动物VEGF受体-2
公开(公告)号：EP1126863A4
公开(公告)日：2003-01-02
申请号：EP99958757
申请日：1999-11-02
申请人： LUDWIG INST CANCER RES , UNIV OTAGO
IPC分类号： G01N33/50 , A61K31/727 , A61K38/00 , A61K45/00 , A61P9/00 , A61P17/00 , C07K14/065 , C07K16/08 , C12N1/21 , C12N5/071 , C12N5/10 , C12N15/09 , C12P21/02 , C12Q1/68 , G01N33/15 , C07H21/04 , C07K17/00 , C12N5/00 , C12N5/06 , C12P21/06
CPC分类号： C07K14/005 , A61K38/00 , C12N5/069 , C12N2710/24222
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7.发明公开PARAPOCKENVIREN, DIE FREMD-DNA ENTHALTEN, IHRE HERSTELLUNG UND IHRE VERWENDUNG IN IMPFSTOFFEN 失效PARA痘病毒，外国DNA包含其疫苗生产和使用
公开(公告)号：EP0886679A1
公开(公告)日：1998-12-30
申请号：EP97904453
申请日：1997-02-17
申请人： BAYER AG
IPC分类号： C12N15/09 , A61K31/00 , A61K35/76 , A61K38/00 , A61K39/00 , A61K48/00 , A61P37/00 , A61P37/02 , A61P43/00 , C07K14/065 , C12N7/00 , C12N7/01 , C12N15/00 , C12N15/863 , C12R1/92 , G01N33/569 , C12N15/86 , A61K39/275 , C12N15/11 , C12N15/39
CPC分类号： C12N15/86 , A61K39/00 , C07K14/005 , C12N2710/24222 , C12N2710/24243
摘要： The invention concerns recombinantly produced parapoxviruses which carry in their genome deletions or insertions in the form of foreign hereditary information and contain other hereditary information. The invention also concerns the production of such constructs and their use in vaccines.
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公开(公告)号：EP3325631A1
公开(公告)日：2018-05-30
申请号：EP16741595.9
申请日：2016-07-15
发明人： RZIHA, Hans-Joachim , AMANN, Ralf
IPC分类号： C12N15/863
CPC分类号： C12N15/86 , A61K39/00 , A61K2039/5154 , C12N2015/8572 , C12N2015/8581 , C12N2710/24031 , C12N2710/24041 , C12N2710/24222 , C12N2710/24243 , C12N2840/10
摘要： The present invention relates to a recombinant Orf virus vector, a cell containing the recombinant Orf virus vector, a composition containing the recombinant Orf virus vector according to the invention and/or containing the cell according to the invention, the use of the recombinant Orf virus vector according to the invention for the production of a foreign gene. The invention also relates to a nucleic acid molecule coding for an Orf virus vector promoter.
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公开(公告)号：EP3307330A1
公开(公告)日：2018-04-18
申请号：EP16812381.8
申请日：2016-06-15
申请人： New York University
发明人： MOHR, Ian J.
CPC分类号： A61K35/768 , A61K38/19 , C07K14/005 , C12N7/00 , C12N2710/24021 , C12N2710/24122 , C12N2710/24132 , C12N2710/24221 , C12N2710/24222 , A61K2300/00
摘要： A method for treating a tumor by administering to a subject in need of such treatment an effective amount for treating the tumor of a Poxviridae decapping deficient mutant virus. Also disclosed are mutant Poxviridae and pharmaceutical formulations for use in the method.
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10.发明授权Recombinant proteins of Parapoxvirus ovis and pharmaceutical compositions therefrom 有权所述Parapoxivirus绵羊的重组蛋白质和它们的药物组合物
公开(公告)号：EP2647645B1
公开(公告)日：2016-07-27
申请号：EP13175420.2
申请日：2002-12-17
发明人： Weber, Olaf , Friederichs, Sonja-Maria , Siegling, Angela , Schlapp, Tobias , Mercer, Andrew Allan , Fleming, Stephen Bruce , Volk, Hans-Dieter
IPC分类号： C07K14/065 , C12N15/863 , A61K39/275 , A61P31/20 , A61P37/00
CPC分类号： C12N15/86 , A61K38/00 , A61K2039/525 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2710/24143 , C12N2710/24221 , C12N2710/24222 , C12N2710/24233 , C12N2710/24243
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