公开(公告)号：EP1442039A1

公开(公告)日：2004-08-04

申请号：EP02777332.4

申请日：2002-10-29

申请人： Bayer HealthCare AG

发明人： LOWINGER, Timothy ,  SHIMAZAKI, Makoto ,  SATO, Hiroki ,  TANAKA, Kazuho ,  TSUNO, Naoki ,  MARX, Karsten ,  YAMAMOTO, Masaru ,  URBAHNS, Klaus ,  GANTNER, Florian ,  OKIGAMI, Hiromi ,  NAKASHIMA, Kosuke ,  TAKESHITA, Keisuke ,  BACON, Kevin B. ,  KOMURA, Hiroshi ,  YOSHIDA, Nagahiro

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P37/00 ,  A61P29/00

CPC分类号： C07D487/04

摘要： The present invention relates to pyrimido[4,5-b]indoles which are useful as an active ingredient of pharmaceutical preparations. The pyrimido[4,5-b]indoles of the present invention have MKK7 and MKK4 inhibitory activity, and can be used for the prophylaxis and treatment of diseases associated with MKK7 and MKK4 activity. Such diseases include, inflammatory and immunoregulatory disorders and diseases such as asthma, atopic dermatitis, rhinitis, allergic rhinitis, allergic diseases, COPD, septic shock, arthritis, joint diseases and myocardial injuries, as well as autoimmune pathologies such as rheumatoid arthritis, Grave's disease, and atherosclerosis. The compounds of the present invention are also useful for treatment of ischemia, myocardial injury, pulmonary hypertension, renal failure, Huntington's chorea and cardiac hypertrophy, as well as neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and focal ischemia.