公开(公告)号：EP1406865B1

公开(公告)日：2006-02-08

申请号：EP02738174.8

申请日：2002-06-24

申请人： Bayer HealthCare AG

发明人： RÖLLE, Thomas ,  LEHMANN, Thomas ,  ALBERS, Markus ,  MÜLLER, Gerhard ,  HESSLER, Gerhard ,  FISCHER, Rüdiger ,  TAJIMI, Masaomi ,  ZIEGELBAUER, Karl ,  BACON, Kevin ,  HASEGAWA, Haruki ,  OKIGAMI, Hiromi

IPC分类号： C07C275/40 ,  A61K31/17 ,  A61P9/10 ,  C07C233/55

CPC分类号： C07C233/55 ,  C07C275/40

摘要： The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory diseases.

公开(公告)号：EP1448180A1

公开(公告)日：2004-08-25

申请号：EP02800566.8

申请日：2002-09-20

申请人： Bayer HealthCare AG

发明人： LEHMANN, Thomas ,  ALBERS, Markus ,  RÖLLE, Thomas ,  MÜLLER, Gerhard ,  HESSLER, Gerhard ,  TAJIMI, Masaomi ,  ZIEGELBAUER, Karl ,  OKIGAMI, Hiromi ,  BACON, Kevin ,  HASEGAWA, Haruki

IPC分类号： A61K31/17 ,  A61K31/423 ,  C07D213/56 ,  C07D277/30 ,  C07D233/54 ,  C07D241/04 ,  C07D211/56 ,  C07D207/14 ,  C07D295/12 ,  C07D207/09 ,  C07D307/14 ,  C07D211/26 ,  C07D213/40 ,  C07D263/58 ,  C07D413/12 ,  C07C275/42 ,  C07D209/20

CPC分类号： C07D207/27 ,  A61K31/192 ,  A61K31/423 ,  C07C275/42 ,  C07D207/09 ,  C07D207/14 ,  C07D209/20 ,  C07D213/40 ,  C07D213/56 ,  C07D233/64 ,  C07D241/04 ,  C07D263/58 ,  C07D277/30 ,  C07D295/13 ,  C07D307/14 ,  C07D413/12

摘要： The present invention relates to compounds of the general formula (I), their preparation and use as pharmaceutical compositions asintegrin antagonists, especially as α4β and/or α4β7 and/or α9β1 intergrin antagonists and in particular for the production of pharmaceutical compositions suitable for the inhibition or the prevention of cell adhesion and cell-adhesion mediated disorders. Examples are the treatment and the prophylaxis of atherosclerosis, asthma, chronic obstructive pulmonary disease (COPD), allergies, diabetes, inflammatory bowel disease, multiple sclerosis, myocardial ischemia, rheumatoid arthritis, transplant rejection and other inflammatory, autoimmune and immune disorders.

公开(公告)号：EP1442039A1

公开(公告)日：2004-08-04

申请号：EP02777332.4

申请日：2002-10-29

申请人： Bayer HealthCare AG

发明人： LOWINGER, Timothy ,  SHIMAZAKI, Makoto ,  SATO, Hiroki ,  TANAKA, Kazuho ,  TSUNO, Naoki ,  MARX, Karsten ,  YAMAMOTO, Masaru ,  URBAHNS, Klaus ,  GANTNER, Florian ,  OKIGAMI, Hiromi ,  NAKASHIMA, Kosuke ,  TAKESHITA, Keisuke ,  BACON, Kevin B. ,  KOMURA, Hiroshi ,  YOSHIDA, Nagahiro

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P37/00 ,  A61P29/00

CPC分类号： C07D487/04

摘要： The present invention relates to pyrimido[4,5-b]indoles which are useful as an active ingredient of pharmaceutical preparations. The pyrimido[4,5-b]indoles of the present invention have MKK7 and MKK4 inhibitory activity, and can be used for the prophylaxis and treatment of diseases associated with MKK7 and MKK4 activity. Such diseases include, inflammatory and immunoregulatory disorders and diseases such as asthma, atopic dermatitis, rhinitis, allergic rhinitis, allergic diseases, COPD, septic shock, arthritis, joint diseases and myocardial injuries, as well as autoimmune pathologies such as rheumatoid arthritis, Grave's disease, and atherosclerosis. The compounds of the present invention are also useful for treatment of ischemia, myocardial injury, pulmonary hypertension, renal failure, Huntington's chorea and cardiac hypertrophy, as well as neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease and focal ischemia.

公开(公告)号：EP1406865A2

公开(公告)日：2004-04-14

申请号：EP02738174.8

申请日：2002-06-24

申请人： Bayer HealthCare AG

发明人： RÖLLE, Thomas ,  LEHMANN, Thomas ,  ALBERS, Markus ,  MÜLLER, Gerhard ,  HESSLER, Gerhard ,  FISCHER, Rüdiger ,  TAJIMI, Masaomi ,  ZIEGELBAUER, Karl ,  BACON, Kevin ,  HASEGAWA, Haruki ,  OKIGAMI, Hiromi

IPC分类号： C07C275/40 ,  A61K31/17 ,  A61P9/10 ,  C07C233/55

CPC分类号： C07C233/55 ,  C07C275/40

摘要： The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory diseases.