公开(公告)号：EP1487842B1

公开(公告)日：2007-03-14

申请号：EP03743829.8

申请日：2003-03-03

申请人： Bayer HealthCare AG

发明人： MURATA, Toshiki ,  SAKAKIBARA, Sachiko ,  YOSHINO, Takashi ,  SATO, Hiroki ,  KORIYAMA, Yuji ,  NUNAMI, Noriko ,  YAMAUCHI, Megumi ,  FUKUSHIMA, Keiko ,  GROSSER, Rolf ,  FUCHIKAMI, Kinji ,  BACON, Kevin ,  LOWINGER, Timothy

IPC分类号： C07D498/04 ,  A61K31/5365 ,  A61P29/00

CPC分类号： C07D498/04

摘要： An optically active (-)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido [2,3-d][1,3]oxazin-2-one of the formula (I) or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.

公开(公告)号：EP1487842A1

公开(公告)日：2004-12-22

申请号：EP03743829.8

申请日：2003-03-03

申请人： Bayer HealthCare AG

发明人： MURATA, Toshiki ,  SAKAKIBARA, Sachiko ,  YOSHINO, Takashi ,  SATO, Hiroki ,  KORIYAMA, Yuji ,  NUNAMI, Noriko ,  YAMAUCHI, Megumi ,  FUKUSHIMA, Keiko ,  GROSSER, Rolf ,  FUCHIKAMI, Kinji ,  BACON, Kevin ,  LOWINGER, Timothy

IPC分类号： C07D498/04 ,  A61K31/5365 ,  A61P29/00

CPC分类号： C07D498/04

摘要： An optically active (-)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido [2,3-d][1,3]oxazin-2-one of the formula (I) or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.

公开(公告)号：EP1461038A1

公开(公告)日：2004-09-29

申请号：EP02772265.1

申请日：2002-09-04

申请人： Bayer HealthCare AG

发明人： LI, Yingfu ,  WATANABE, Akihiko ,  LOWINGER, Timothy, B. ,  BACON, Kevin ,  KAWAMURA, Norihiro ,  SHINTANI, Takuya ,  KIKUCHI, Tetsuo ,  MORIWAKI, Toshiya ,  URBAHNS, Klaus ,  FUKUSHIMA, Keiko ,  NUNAMI, Noriko ,  YOSHINO, Takashi ,  MURATA, Toshiki ,  YAMAUCHI, Megumi ,  YOSHINO, Hiroko

IPC分类号： A61K31/445 ,  A61K31/496 ,  A61P11/06 ,  A61P37/00 ,  A61P29/00 ,  C07D295/22 ,  C07D471/04 ,  C07D211/58 ,  C07D243/06 ,  C07D211/28 ,  C07C311/18 ,  C07D211/96 ,  C07D307/14 ,  C07D207/14 ,  C07D213/71

CPC分类号： C07D213/70 ,  C07C311/29 ,  C07C323/67 ,  C07D207/14 ,  C07D207/48 ,  C07D209/08 ,  C07D211/28 ,  C07D211/58 ,  C07D211/96 ,  C07D213/65 ,  C07D213/71 ,  C07D213/75 ,  C07D213/76 ,  C07D213/80 ,  C07D241/04 ,  C07D241/06 ,  C07D243/08 ,  C07D257/04 ,  C07D295/088 ,  C07D295/13 ,  C07D295/194 ,  C07D295/26 ,  C07D307/14 ,  C07D333/38 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08

摘要： The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.