公开(公告)号：EP1597262A2

公开(公告)日：2005-11-23

申请号：EP04708731.7

申请日：2004-02-06

申请人： Bayer HealthCare AG

发明人： STADLER, Marc ,  SEIP, Stephan ,  MÜLLER, Hartwig ,  MAYER-BARTSCHMID, Anke ,  BRÜNING, Michael-Alexander ,  BENET-BUCHHOLZ, Jordi ,  TOGAME, Hiroko ,  DODO, Reiko ,  REINEMER, Peter ,  BACON, Kevin ,  FUCHIKAMI, Kinji ,  MATSUKAWA, Satoko ,  URBAHNS, Klaus

IPC分类号： C07D491/04 ,  C07D207/26 ,  A61P35/00

CPC分类号： C12P17/10 ,  C07D207/277 ,  C07D491/04 ,  C12P17/188 ,  C12R1/465

摘要： The present invention relates to substituted heterocycles, processes for their preparation, and their use in medicaments, especially for the treatment of inflammatory disease, i.e. asthma, or cancer.

公开(公告)号：EP1406865B1

公开(公告)日：2006-02-08

申请号：EP02738174.8

申请日：2002-06-24

申请人： Bayer HealthCare AG

发明人： RÖLLE, Thomas ,  LEHMANN, Thomas ,  ALBERS, Markus ,  MÜLLER, Gerhard ,  HESSLER, Gerhard ,  FISCHER, Rüdiger ,  TAJIMI, Masaomi ,  ZIEGELBAUER, Karl ,  BACON, Kevin ,  HASEGAWA, Haruki ,  OKIGAMI, Hiromi

IPC分类号： C07C275/40 ,  A61K31/17 ,  A61P9/10 ,  C07C233/55

CPC分类号： C07C233/55 ,  C07C275/40

摘要： The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory diseases.

公开(公告)号：EP1448180A1

公开(公告)日：2004-08-25

申请号：EP02800566.8

申请日：2002-09-20

申请人： Bayer HealthCare AG

发明人： LEHMANN, Thomas ,  ALBERS, Markus ,  RÖLLE, Thomas ,  MÜLLER, Gerhard ,  HESSLER, Gerhard ,  TAJIMI, Masaomi ,  ZIEGELBAUER, Karl ,  OKIGAMI, Hiromi ,  BACON, Kevin ,  HASEGAWA, Haruki

IPC分类号： A61K31/17 ,  A61K31/423 ,  C07D213/56 ,  C07D277/30 ,  C07D233/54 ,  C07D241/04 ,  C07D211/56 ,  C07D207/14 ,  C07D295/12 ,  C07D207/09 ,  C07D307/14 ,  C07D211/26 ,  C07D213/40 ,  C07D263/58 ,  C07D413/12 ,  C07C275/42 ,  C07D209/20

CPC分类号： C07D207/27 ,  A61K31/192 ,  A61K31/423 ,  C07C275/42 ,  C07D207/09 ,  C07D207/14 ,  C07D209/20 ,  C07D213/40 ,  C07D213/56 ,  C07D233/64 ,  C07D241/04 ,  C07D263/58 ,  C07D277/30 ,  C07D295/13 ,  C07D307/14 ,  C07D413/12

摘要： The present invention relates to compounds of the general formula (I), their preparation and use as pharmaceutical compositions asintegrin antagonists, especially as α4β and/or α4β7 and/or α9β1 intergrin antagonists and in particular for the production of pharmaceutical compositions suitable for the inhibition or the prevention of cell adhesion and cell-adhesion mediated disorders. Examples are the treatment and the prophylaxis of atherosclerosis, asthma, chronic obstructive pulmonary disease (COPD), allergies, diabetes, inflammatory bowel disease, multiple sclerosis, myocardial ischemia, rheumatoid arthritis, transplant rejection and other inflammatory, autoimmune and immune disorders.

公开(公告)号：EP1406865A2

公开(公告)日：2004-04-14

申请号：EP02738174.8

申请日：2002-06-24

申请人： Bayer HealthCare AG

发明人： RÖLLE, Thomas ,  LEHMANN, Thomas ,  ALBERS, Markus ,  MÜLLER, Gerhard ,  HESSLER, Gerhard ,  FISCHER, Rüdiger ,  TAJIMI, Masaomi ,  ZIEGELBAUER, Karl ,  BACON, Kevin ,  HASEGAWA, Haruki ,  OKIGAMI, Hiromi

IPC分类号： C07C275/40 ,  A61K31/17 ,  A61P9/10 ,  C07C233/55

CPC分类号： C07C233/55 ,  C07C275/40

摘要： The present invention relates to compounds of the general formula (I), processes for their preparation, pharmaceutical compositions containing them as well as their use for the production of pharmaceutical compositions for the treatment of inflammatory diseases.

公开(公告)号：EP1487842B1

公开(公告)日：2007-03-14

申请号：EP03743829.8

申请日：2003-03-03

申请人： Bayer HealthCare AG

发明人： MURATA, Toshiki ,  SAKAKIBARA, Sachiko ,  YOSHINO, Takashi ,  SATO, Hiroki ,  KORIYAMA, Yuji ,  NUNAMI, Noriko ,  YAMAUCHI, Megumi ,  FUKUSHIMA, Keiko ,  GROSSER, Rolf ,  FUCHIKAMI, Kinji ,  BACON, Kevin ,  LOWINGER, Timothy

IPC分类号： C07D498/04 ,  A61K31/5365 ,  A61P29/00

CPC分类号： C07D498/04

摘要： An optically active (-)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido [2,3-d][1,3]oxazin-2-one of the formula (I) or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.

公开(公告)号：EP1487842A1

公开(公告)日：2004-12-22

申请号：EP03743829.8

申请日：2003-03-03

申请人： Bayer HealthCare AG

发明人： MURATA, Toshiki ,  SAKAKIBARA, Sachiko ,  YOSHINO, Takashi ,  SATO, Hiroki ,  KORIYAMA, Yuji ,  NUNAMI, Noriko ,  YAMAUCHI, Megumi ,  FUKUSHIMA, Keiko ,  GROSSER, Rolf ,  FUCHIKAMI, Kinji ,  BACON, Kevin ,  LOWINGER, Timothy

IPC分类号： C07D498/04 ,  A61K31/5365 ,  A61P29/00

CPC分类号： C07D498/04

摘要： An optically active (-)-7-[2-(cyclopropylmethoxy)-6-hydroxyphenyl]-5-[(3S)-3-piperidinyl]-1,4-dihydro-2H-pyrido [2,3-d][1,3]oxazin-2-one of the formula (I) or salt thereof. The compound has an excellent anti-inflammatory activity, and other biological activity.

公开(公告)号：EP1461038A1

公开(公告)日：2004-09-29

申请号：EP02772265.1

申请日：2002-09-04

申请人： Bayer HealthCare AG

发明人： LI, Yingfu ,  WATANABE, Akihiko ,  LOWINGER, Timothy, B. ,  BACON, Kevin ,  KAWAMURA, Norihiro ,  SHINTANI, Takuya ,  KIKUCHI, Tetsuo ,  MORIWAKI, Toshiya ,  URBAHNS, Klaus ,  FUKUSHIMA, Keiko ,  NUNAMI, Noriko ,  YOSHINO, Takashi ,  MURATA, Toshiki ,  YAMAUCHI, Megumi ,  YOSHINO, Hiroko

IPC分类号： A61K31/445 ,  A61K31/496 ,  A61P11/06 ,  A61P37/00 ,  A61P29/00 ,  C07D295/22 ,  C07D471/04 ,  C07D211/58 ,  C07D243/06 ,  C07D211/28 ,  C07C311/18 ,  C07D211/96 ,  C07D307/14 ,  C07D207/14 ,  C07D213/71

CPC分类号： C07D213/70 ,  C07C311/29 ,  C07C323/67 ,  C07D207/14 ,  C07D207/48 ,  C07D209/08 ,  C07D211/28 ,  C07D211/58 ,  C07D211/96 ,  C07D213/65 ,  C07D213/71 ,  C07D213/75 ,  C07D213/76 ,  C07D213/80 ,  C07D241/04 ,  C07D241/06 ,  C07D243/08 ,  C07D257/04 ,  C07D295/088 ,  C07D295/13 ,  C07D295/194 ,  C07D295/26 ,  C07D307/14 ,  C07D333/38 ,  C07D471/04 ,  C07D487/04 ,  C07D487/08

摘要： The present invention relates to a sulfonamide derivative which is useful as an active ingredient of pharmaceutical preparations. The sulfonamide derivatives of the present invention have CCR3 (CC type chemokine receptor) antagonistic activity, and can be used for the prophylaxis and treatment of diseases associated with CCR3 activity, in particular for the treatment of asthma, atopic dermatitis, allergic rhinitis and other inflammatory/immunological disorders.