-
公开(公告)号：EP3292874B1
公开(公告)日：2020-04-08
申请号：EP17189537.8
申请日：2010-04-16
-
公开(公告)号：EP2424569B1
公开(公告)日：2017-10-18
申请号：EP10715114.4
申请日：2010-04-16
发明人： KAHNERT, Antje , BERHÖRSTER, Kerstin , HEISLER, Iring , KOPITZ, Charlotte Christine , SCHUMACHER, Joachim
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6851 , C07K2317/14 , C07K2317/56 , C07K2317/565
-
公开(公告)号：EP3292874A1
公开(公告)日：2018-03-14
申请号：EP17189537.8
申请日：2010-04-16
发明人： KAHNERT, Antje , UNTERSCHEMMANN, Kerstin , HEISLER, Iring , KOPITZ, Charlotte Christine , SCHUHMACHER, Joachim
摘要： The present invention provides immunoconjugates composed of antibodies, e.g., monoclonal antibodies, or antibody fragments that bind to mesothelin, that are conjugated to cytotoxic agents, e.g., maytansine, or derivatives thereof, and/or co- administered or formulated with one or more additional anti-cancer agents. The immunoconjugates of the invention can be used in the methods of the invention to treat and/or diagnose and/or monitor cancers, e.g. solid tumors.recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 40 kDa mesothelin polypeptide, which which is overexpressed in several tumors, such as pancreatic and ovarian tumors, mesothelioma and lung cancer cells
摘要翻译： 本发明提供了由抗体例如单克隆抗体或与间皮素结合的抗体片段组成的免疫缀合物，所述抗体与细胞毒性剂例如美登素或其衍生物缀合和/或与一种或多种另外的 抗癌剂。 本发明的免疫缀合物可用于本发明的方法中以治疗和/或诊断和/或监测癌症，例如癌症。 重组抗原结合区和抗体以及含有特异于膜锚定的40kDa间皮素多肽的这种抗原结合区的功能片段，其在几种肿瘤中过表达，如胰腺癌和卵巢肿瘤，间皮瘤和 肺癌细胞
-
-
搜索结果
3 条记录 (耗时 0.012 秒)
