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公开(公告)号：EP2665751A1
公开(公告)日：2013-11-27
申请号：EP12700348.1
申请日：2012-01-17
发明人： DITTMER, Frank , BUCHMÜLLER, Anja , GERDES, Christoph , TERSTEEGEN, Adrian , GNOTH, Mark, Jean , LINDEN, Lars , HARRENGA, Axel , GRUDZINSKA-GOEBEL, Joanna , JESKE, Mario , SCHÄFER, Martina , BIRKENFELD, Jörg , PAULSEN, Holger , FINNERN, Ricarda , MAYER-BARTSCHMID, Anke , EICKER, Andrea , GREVEN, Simone , STEINIG, Susanne
CPC分类号： C07K16/44 , A61K2039/505 , A61K2300/00 , C07K2317/55 , C07K2317/76
摘要： The present invention relates to the identification and use of antigen-binding regions, antibodies, antigen-binding antibody fragments and antibody mimetics, neutralizing the anti-coagulant effect of an anticoagulant in vitro and/or in vivo. Antibodies and functional fragments of the invention and antibody mimetics can be used to specifically reverse the pharmacological effect of an anticoagulant e.g. a FX a inhibitor for therapeutic (antidote) and/or diagnostic purposes. The invention also provides nucleic acid sequences encoding foregoing molecules, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
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公开(公告)号：EP2225276B1
公开(公告)日：2014-04-23
申请号：EP08866799.3
申请日：2008-12-24
发明人： VOTSMEIER, Christian , GRITZAN, Uwe , KIRCHNER, Kornelia , STRERATH, Michael , BARAL, Kerstin , HAUPTS, Ulrich , COCO, Wayne, M. , STEINIG, Susanne , SCHEIDIG, Andreas , PELLENGAHR, Klaus , BRÜCKNER, Simone , PLITTERSDORF, Hanna , SCHOLZ, Peter , TEBBE, Jan
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/241 , C07K2317/14 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/76 , C07K2317/90 , C07K2317/92
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