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公开(公告)号：EP2435428B1
公开(公告)日：2013-07-31
申请号：EP10721991.7
申请日：2010-05-14
发明人： HEIMBACH, Dirk , RÖHRIG, Susanne , CANCHO GRANDE, Yolanda , RESTER, Ulrich , BENDER, Eckhard , ZIMMERMANN, Katja , ZUBOV, Dmitry , BUCHMÜLLER, Anja , VON DEGENFELD, Georges , GERDES, Christoph , GNOTH, Mark, Jean , GERICKE, Kersten, Matthias , JESKE, Mario
IPC分类号： C07D413/06 , C07D417/06 , C07D211/20 , C07D211/22 , C07D211/24 , C07D211/26 , C07D211/34 , C07D401/06
CPC分类号： C07D211/34 , C07D211/20 , C07D211/22 , C07D211/24 , C07D211/26 , C07D401/06 , C07D417/06
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公开(公告)号：EP2411363B1
公开(公告)日：2015-10-07
申请号：EP10708146.5
申请日：2010-03-12
发明人： JESKE, Mario , HEIMBACH, Dirk , RÖHRIG, Susanne , CANCHO GRANDE, Yolanda , SCHNEIDER, Dirk , RESTER, Ulrich , BENDER, Eckhard , MEININGHAUS, Mark , ZIMMERMANN, Katja , ZUBOV, Dmitry , BUCHMÜLLER, Anja , VON DEGENFELD, Georges , GERDES, Christoph , GERISCH, Michael , GNOTH, Mark, Jean , GERICKE, Kersten, Matthias
IPC分类号： C07D211/42 , C07D211/56 , C07D211/60 , C07D211/62 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/06 , A61K31/451 , A61K31/4525 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K9/20 , A61K9/08 , A61K9/10
CPC分类号： C07D417/06 , A61K9/0019 , A61K9/10 , A61K9/2018 , A61K31/451 , A61K31/4523 , A61K31/4525 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/10 , A61K47/36 , C07D211/42 , C07D211/56 , C07D211/60 , C07D211/62 , C07D401/06 , C07D405/06 , C07D405/12 , C07D409/12 , C07D413/12
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公开(公告)号：EP2665751A1
公开(公告)日：2013-11-27
申请号：EP12700348.1
申请日：2012-01-17
发明人： DITTMER, Frank , BUCHMÜLLER, Anja , GERDES, Christoph , TERSTEEGEN, Adrian , GNOTH, Mark, Jean , LINDEN, Lars , HARRENGA, Axel , GRUDZINSKA-GOEBEL, Joanna , JESKE, Mario , SCHÄFER, Martina , BIRKENFELD, Jörg , PAULSEN, Holger , FINNERN, Ricarda , MAYER-BARTSCHMID, Anke , EICKER, Andrea , GREVEN, Simone , STEINIG, Susanne
CPC分类号： C07K16/44 , A61K2039/505 , A61K2300/00 , C07K2317/55 , C07K2317/76
摘要： The present invention relates to the identification and use of antigen-binding regions, antibodies, antigen-binding antibody fragments and antibody mimetics, neutralizing the anti-coagulant effect of an anticoagulant in vitro and/or in vivo. Antibodies and functional fragments of the invention and antibody mimetics can be used to specifically reverse the pharmacological effect of an anticoagulant e.g. a FX a inhibitor for therapeutic (antidote) and/or diagnostic purposes. The invention also provides nucleic acid sequences encoding foregoing molecules, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
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