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1.发明公开SUBSTITUTED (HETEROARYLMETHYL) THIOHYDANTOINS AS ANTICANCER DRUGS 审中-公开取代的（杂芳）-THIOHYDANTOINE ALS肿瘤剂
公开(公告)号：EP2475366A1
公开(公告)日：2012-07-18
申请号：EP10747893.5
申请日：2010-09-03
发明人： CLEVE, Arwed , LÜCKING, Ulrich , BÄURLE, Stefan , FRITSCH, Martin , SCHRÖDER, Jens , IGL, Bernd-Wolfgang
IPC分类号： A61K31/4439 , A61P35/00 , A61K31/275
CPC分类号： A61K31/275 , A61K31/4439
摘要： The invention refers to the use of androgen receptor antagonists for the treatment and/or prevention of fibroids, also known as uterine leiomyoma, leiomyomata. Particularly, the invention refers to the use of an androgen receptor antagonist being any one of the compounds according to the following list: cyproterone acetate, oxendolone, chlormadinone acetate, spironolactone, osaterone acetate, dienogest, flutamide, hydroxyflutamide, nilutamide, bicalutamide, RU 58841, LGD-2226, MDV3100, BMS-641988, BMS-779333, or 4-(3-{[6-(2-hydroxy-2-methylpropoxy)pyridin-3-yl]methyl}-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile (thioxoimidazolidine derivative) for the treatment of fibroids.
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2.发明授权N-[4-(QUINOLIN-4-YLOXY)CYCLOHEXYL(METHYL)](HETERO)ARYLCARBOXAMIDES AS ANDROGEN RECEPTOR ANTAGONISTS, PRODUCTION AND USE THEREOF AS MEDICINAL PRODUCTS 有权N- [4-（喹啉-4-基氧基）（环己基）甲基）]杂）ARYLCARBOXAMIDE ALS雄激素受体拮抗剂，其生产和使用作为药物的
公开(公告)号：EP2864291B1
公开(公告)日：2016-10-05
申请号：EP13731325.0
申请日：2013-06-24
发明人： NGUYEN, Duy , KÜNZER, Hermann , FAUS GIMENEZ, Hortensia , BADER, Benjamin , KÖHR, Silke , FRITSCH, Martin
IPC分类号： C07D215/233 , C07D401/12 , C07D413/12 , A61K31/47 , A61K31/4709 , A61P35/00
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , C07D401/12 , C07D413/12
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3.发明公开N-[4-(QUINOLIN-4-YLOXY)CYCLOHEXYL(METHYL)](HETERO)ARYLCARBOXAMIDES AS ANDROGEN RECEPTOR ANTAGONISTS, PRODUCTION AND USE THEREOF AS MEDICINAL PRODUCTS 有权N- [4-（喹啉-4-基氧基）（环己基）甲基）]杂）ARYLCARBOXAMIDE ALS雄激素受体拮抗剂，其生产和使用作为药物的
公开(公告)号：EP2864291A1
公开(公告)日：2015-04-29
申请号：EP13731325.0
申请日：2013-06-24
发明人： NGUYEN, Duy , KÜNZER, Hermann , FAUS GIMENEZ, Hortensia , BADER, Benjamin , KÖHR, Silke , FRITSCH, Martin
IPC分类号： C07D215/233 , C07D401/12 , C07D413/12 , A61K31/47 , A61K31/4709 , A61P35/00
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , C07D401/12 , C07D413/12
摘要： The invention relates to N-[4-(quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides, intermediates and methods for their production, use thereof for treating and/or preventing diseases and use thereof for producing medicinal products and use thereof for treating and/or preventing diseases, especially of hyperproliferative diseases.
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