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公开(公告)号：EP3601267A1
公开(公告)日：2020-02-05
申请号：EP18717840.5
申请日：2018-03-19
发明人： WORTMANN, Lars , SAUTIER, Brice , EIS, Knut , BRIEM, Hans , BÖHNKE, Niels , VON NUSSBAUM, Franz , HILLIG, Roman , BADER, Benjamin , SCHRÖDER, Jens , PETERSEN, Kirstin , LIENAU, Philip , WENGNER, Antje, Margret , MOOSMAYER, Dieter , WANG, Qiuwen , SCHICK, Hans
IPC分类号： C07D403/12 , C07D405/14 , C07D401/12 , C07D403/04 , C07D405/10 , C07D405/12 , C07D409/12 , C07D409/14 , C07D239/94 , C07D417/12 , C07D487/04 , C07D495/04 , A61P35/00 , A61K31/517
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公开(公告)号：EP3390387A1
公开(公告)日：2018-10-24
申请号：EP16829402.3
申请日：2016-12-15
发明人： SCHULZE, Volker , HEINRICH, Tobias , PRINZ, Florian , LEFRANC, Julien , SCHRÖDER, Jens , MENGEL, Anne , BONE, Wilhelm , BÁLINT, Joszef , WENGNER, Antje Margret , EIS, Knut , IRLBACHER, Horst , KOPPITZ, Marcus , BÖMER, Ulf , BADER, Benjamin , BRIEM, Hans , LIENAU, Philip , CHRIST, Clara , STÖCKIGT, Detlef , HILLIG, Roman , EHEIM, Ashley , KOSEMUND, Dirk , MÖNNING, Ursula , HARB, Hassan, Y.
IPC分类号： C07D401/14 , C07D405/14 , C07D401/12 , C07D409/14 , C07D451/14 , C07D471/08 , C07D487/08 , A61K31/407
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D451/14 , C07D471/08 , C07D487/08
摘要： The present invention covers heteroarylbenzimidazole compounds of general formula (I) in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative and/or inflammatory disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：EP3010907A1
公开(公告)日：2016-04-27
申请号：EP14738399.6
申请日：2014-06-17
发明人： HILGER, Christoph-Stephan , HITCHCOCK, Marion , BRIEM, Hans , SIEMEISTER, Gerhard , FERNÁNDEZ-MONTALVÁN, Amaury Ernesto , SCHRÖDER, Jens , HOLTON, Simon , PREUSSE, Cornelia , DENNER, Karsten
IPC分类号： C07D401/14 , C07D403/14 , C07D498/04 , A61K31/506 , A61K31/53 , A61K31/5365 , A61P35/00
CPC分类号： C07D498/04 , A61K31/506 , A61K31/53 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07D401/14 , C07D403/14
摘要： Compounds of formula (I), which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物，其生产方法及其作为药物的用途。
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公开(公告)号：EP3010902A1
公开(公告)日：2016-04-27
申请号：EP14730907.4
申请日：2014-06-17
发明人： HITCHCOCK, Marion , MENGEL, Anne , BRIEM, Hans , LÜCKING, Ulrich , SIEMEISTER, Gerhard , BONE, Wilhelm , SCHRÖDER, Jens , BAIRLEIN, Michaela , MÖNNING, Ursula , BRÜNING, Michael
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00
CPC分类号： A61K31/506 , A61K45/06 , C07D401/14
摘要： Compounds of formula (I) and their use as pharmaceutical.
摘要翻译： 式（I）化合物及其作为药物的用途。
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公开(公告)号：EP3194381A1
公开(公告)日：2017-07-26
申请号：EP15763929.5
申请日：2015-09-17
发明人： MENGEL, Anne , MÜLLER, Thomas , BÄRFACKER, Lars , HITCHCOCK, Marion , CLEVE, Arwed , BRIEM, Hans , SIEMEISTER, Gerhard , BONE, Wilhelm , FERNANDEZ-MONTALVAN, Amaury Ernesto , SCHRÖDER, Jens , MÖNNING, Ursula
IPC分类号： C07D401/14 , C07D403/14 , A61K31/506 , A61K31/5377 , A61P35/00
CPC分类号： C07D401/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D403/14
摘要： Compounds of formula (I) and their use as pharmaceuticals.
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公开(公告)号：EP3194380A1
公开(公告)日：2017-07-26
申请号：EP15763928.7
申请日：2015-09-17
发明人： MENGEL, Anne , LERCHEN, Hans-Georg , MÜLLER, Thomas , BÄRFACKER, Lars , HITCHCOCK, Marion , CLEVE, Arwed , BRIEM, Hans , SIEMEISTER, Gerhard , BONE, Wilhelm , FERNÁNDEZ-MONTALVÁN, Amaury Ernesto , SCHRÖDER, Jens , MÖNNING, Ursula , HOLTON, Simon
IPC分类号： C07D401/14 , C07D403/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , A61K31/506 , A61K45/06 , C07D403/14 , C07D405/14
摘要： Compounds of formula (I) and their use as pharmaceuticals.
摘要翻译： 式（I）化合物及其作为药物的用途。
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公开(公告)号：EP2976336A1
公开(公告)日：2016-01-27
申请号：EP14714196.4
申请日：2014-03-20
发明人： HITCHCOCK, Marion , MENGEL, Anne , BRIEM, Hans , EIS, Knut , SIEMEISTER, Gerhard , BONE, Wilhelm , FERNÁNDEZ-MONTALVÁN, Amaury, Ernesto , SCHRÖDER, Jens , HOLTON, Simon , PREUSSE, Cornelia , PÜTTER, Vera
IPC分类号： C07D401/14 , A61K31/506 , C07D403/14 , C07D417/14 , C07D471/04 , A61P35/00
CPC分类号： C07D403/14 , A61K31/4439 , A61K31/506 , A61K31/53 , A61K45/06 , C07D401/14 , C07D403/04 , C07D417/14 , C07D471/04
摘要： Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物，它们的制备方法和它们作为药物的用途。
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公开(公告)号：EP2976335A1
公开(公告)日：2016-01-27
申请号：EP14711968.9
申请日：2014-03-20
发明人： HITCHCOCK, Marion , MENGEL, Anne , HILGER, Christoph-Stephan , BÄRFACKER, Lars , BRIEM, Hans , SIEMEISTER, Gerhard , FERNÁNDEZ-MONTALVÁN, Amaury Ernesto , SCHRÖDER, Jens , HOLTON, Simon , PREUßE, Cornelia , MÖNNING, Ursula
IPC分类号： C07D401/14 , C07D413/14 , A61K31/506 , C07D417/14 , C07D498/04 , A61P9/10
CPC分类号： C07D401/14 , A61K31/506 , A61K31/513 , A61K31/519 , A61K45/06 , C07D413/14 , C07D417/14 , C07D487/04
摘要： Compounds of formula (I), which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.
摘要翻译： 作为Bub1激酶抑制剂的式（I）化合物处理其生产和用作药物。
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公开(公告)号：EP3781565A1
公开(公告)日：2021-02-24
申请号：EP19720074.4
申请日：2019-04-15
发明人： WORTMANN, Lars , SAUTIER, Brice , EIS, Knut , BRIEM, Hans , BÖHNKE, Niels , VON NUSSBAUM, Franz , HILIG, Roman , BADER, Benjamin , SCHRÖDER, Jens , PETERSEN, Kirstin , LIENAU, Philip , WENGNER, Antje, Margret , MOOSMAYER, Dieter , WANG, Qiuwen
IPC分类号： C07D471/04 , A61K31/519 , A61P35/00
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公开(公告)号：EP3194378A1
公开(公告)日：2017-07-26
申请号：EP15763573.1
申请日：2015-09-15
发明人： BÄRFACKER, Lars , MÜLLER, Thomas , MENGEL, Anne , HITCHCOCK, Marion , CLEVE, Arwed , BRIEM, Hans , SIEMEISTER, Gerhard , BONE, Wilhelm , FERNANDEZ-MONTALVAN, Amaury Ernesto , SCHRÖDER, Jens , MÖNNING, Ursula
IPC分类号： C07D401/14 , C07D413/14 , C07D403/04 , C07D417/14 , A61K31/506
CPC分类号： C07D401/14 , A61K31/506 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/695 , A61K45/06 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D491/052 , C07D495/04 , C07F7/1804
摘要： Compounds of formula (I) and their use as pharmaceuticals.
摘要翻译： 式（I）化合物及其作为药物的用途。
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