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1.发明公开
公开(公告)号：EP3307741A1
公开(公告)日：2018-04-18
申请号：EP16727193.1
申请日：2016-06-06
发明人： TELLER, Henrik , STRAUB, Alexander , BRECHMANN, Markus , MÜLLER, Thomas , MEININGHAUS, Mark , NOWAK-REPPEL, Katrin , TINEL, Hanna , MÜNTER, Klaus , FLIEGNER, Daniela , MONDRITZKI, Thomas , BOULTADAKIS ARAPINIS, Melissa , MARQUARDT, Tobias , VAKALOPOULOS, Alexandros , REBSTOCK, Anne-Sophie , WITTWER, Matthias, Beat
IPC分类号： C07D471/04 , A61K31/4375 , A61P9/06 , A61P13/12
摘要： The present application relates to positive allosteric modulators of the muscarinic M2 receptor, in particular novel 7-substituted 1-aryl-naphthyridin-3-carboxylic acid amides, to processes for the preparation thereof, to the use thereof alone or in combinations for the treatment and/or prevention of diseases, and to the use thereof for the production of medicaments for the treatment and/or prevention of diseases, particular for the treatment and/or prevention of cardiovascular disorders and/or renal diseases.
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公开(公告)号：EP3066098A1
公开(公告)日：2016-09-14
申请号：EP14799129.3
申请日：2014-11-05
发明人： FÜRSTNER, Chantal , ACKERSTAFF, Jens , STRAUB, Alexander , MEIER, Heinrich , TINEL, Hanna , ZIMMERMANN, Katja , TERSTEEGEN, Adrian , ZUBOV, Dmitry , KAST, Raimund , SCHAMBERGER, Jens , SCHÄFER, Martina
IPC分类号： C07D413/14 , C07D403/10 , C07D409/06 , C07D239/557 , C07D413/10 , C07D417/10 , A61K31/513 , A61P11/06 , A61P13/12 , A61P9/00
CPC分类号： C07D239/557 , A61K31/513 , C07D403/10 , C07D409/06 , C07D413/10 , C07D413/14 , C07D417/10
摘要： The present application relates to novel substituted uracil derivatives of formula (I), to a method for the production thereof, to the use thereof either alone or in combination for treating and/or preventing diseases, and to the use thereof for producing pharmaceuticals for the treatment and/or prevention of diseases.
摘要翻译： 本申请涉及式（I）的新型取代的尿嘧啶衍生物，其制备方法单独使用或组合用于治疗和/或预防疾病的用途，以及其用于生产药物的用途 治疗和/或预防疾病。
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公开(公告)号：EP2847190A1
公开(公告)日：2015-03-18
申请号：EP13720407.9
申请日：2013-05-03
发明人： FÜRSTNER, Chantal , ACKERSTAFF, Jens , STRAUB, Alexander , MEIER, Heinrich , TINEL, Hanna , ZIMMERMANN, Katja , TERSTEEGEN, Adrian , ZUBOV, Dmitry , KAST, Raimund , SCHAMBERGER, Jens , SCHÄFER, Martina , BÖRNGEN, Kirsten
IPC分类号： C07D413/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04 , A61K38/04
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
摘要： The present application relates to novel bicyclically substituted uracil derivatives, to a method for the production thereof, and to a method for the use thereof, alone or in combination, for treatment and/or prophylaxis of diseases, and to the use thereof for producing pharmaceuticals for treatment and/or prophylaxis of diseases.
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公开(公告)号：EP3481823B1
公开(公告)日：2020-10-28
申请号：EP17733874.6
申请日：2017-07-04
发明人： TELLER, Henrik , BOULTADAKIS ARAPINIS, Melissa , VAKALOPOULOS, Alexandros , REBSTOCK, Anne-Sophie , STRAUB, Alexander , TINEL, Hanna , BRECHMANN, Markus , WITTWER, Matthias, Beat , KULLMANN, Maximilian, Andreas , MÜNTER, Klaus , MONDRITZKI, Thomas , MARQUARDT, Tobias
IPC分类号： C07D471/04
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公开(公告)号：EP3700903A1
公开(公告)日：2020-09-02
申请号：EP18785687.7
申请日：2018-10-18
发明人： MEIBOM, Daniel , MEYER, Jutta , COLLINS, Karl , ORTEGA HERNANDEZ, Nuria , STAMPFUSS, Jan , WUNDER, Frank , FREUDENBERGER, Till , MONDRITZKI, Thomas , SCHEERER, Nina Alexandra , LEINEWEBER, Kirsten , SCHAMBERGER, Jens , STRAUB, Alexander , GERICKE Kersten, Matthias , KROH, Walter , LOBELL, Mario , MÜNTER, Klaus
IPC分类号： C07D471/04 , C07D519/00 , A61P9/00 , A61K31/437
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公开(公告)号：EP3481823A1
公开(公告)日：2019-05-15
申请号：EP17733874.6
申请日：2017-07-04
发明人： TELLER, Henrik , BOULTADAKIS ARAPINIS, Melissa , VAKALOPOULOS, Alexandros , REBSTOCK, Anne-Sophie , STRAUB, Alexander , TINEL, Hanna , BRECHMANN, Markus , WITTWER, Matthias, Beat , KULLMANN, Maximilian, Andreas , MÜNTER, Klaus , MONDRITZKI, Thomas , MARQUARDT, Tobias
IPC分类号： C07D471/04
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公开(公告)号：EP3066096A1
公开(公告)日：2016-09-14
申请号：EP14799368.7
申请日：2014-11-05
发明人： FÜRSTNER, Chantal , ACKERSTAFF, Jens , STRAUB, Alexander , MEIER, Heinrich , TINEL, Hanna , ZIMMERMANN, Katja , ZUBOV, Dmitry , SCHAMBERGER, Jens
IPC分类号： C07D403/04 , C07D413/04 , C07D417/04 , C07D239/54 , C07D403/12 , C07D417/12 , C07D413/12 , C07D403/10 , C07D413/10 , A61K31/513 , A61P9/00
CPC分类号： C07D239/557 , A61K9/0053 , A61K9/08 , A61K9/20 , A61K31/513 , A61K45/06 , C07D239/54 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D413/04 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present application relates to novel substituted uracil derivatives, to a method for the production thereof, to the use thereof either alone or in combination for treating and/or preventing diseases, and to the use thereof for producing pharmaceuticals for the treatment and/or prevention of diseases.
摘要翻译： 式（I）的取代的尿嘧啶衍生物，其制备方法，其单独使用或组合用于治疗和/或预防疾病及其用于制备用于治疗和/或预防疾病的药物的用途。
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8.发明公开HYDROXY-SUBSTITUIERTE IMIDAZO[1,2-A]PYRIDINCARBOXAMIDE UND IHRE VERWENDUNG ALS STIMULATOREN DER LÖSLICHEN GUANYLATCYCLASE 有权羟基取代的咪唑并[1,2-A]吡啶甲酰胺在IHRE VERWENDUNG ALS STIMULATOREN DERLÖSLICHENGUANYLATCYCLASE
公开(公告)号：EP2914596A1
公开(公告)日：2015-09-09
申请号：EP13789237.8
申请日：2013-11-04
发明人： VAKALOPOULOS, Alexandros , HARTUNG, Ingo , FOLLMANN, Markus , JAUTELAT, Rolf , STRAUB, Alexander , HAßFELD, Jorma , LINDNER, Niels , SCHNEIDER, Dirk , WUNDER, Frank , STASCH, Johannes-Peter , REDLICH, Gorden , LI, Volkhart Min-Jian , BECKER-PELSTER, Eva-Maria , KNORR, Andreas
IPC分类号： C07D471/04 , A61K31/437 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/12
CPC分类号： C07D471/04 , A61K31/437 , A61K31/444 , A61K31/5377 , A61K45/06
摘要： The invention relates to novel substituted imidazo[1,2-a]pyridino-3-carboxamides of formula (I) in which R
3 is a group of formula (II) or (III), to methods for their production, their use alone or in combination for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular diseases.摘要翻译： 本申请涉及新型取代的咪唑并[1,2-a]吡啶-3-甲酰胺，用于其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途 用于治疗和/或预防疾病，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：EP3692991A1
公开(公告)日：2020-08-12
申请号：EP19216135.4
申请日：2016-06-06
发明人： TELLER, Henrik , STRAUB, Alexander , BRECHMANN, Markus , MÜLLER, Thomas , MEININGHAUS, Mark , NOWAK-REPPEL, Katrin , TINEL, Hanna , MÜNTER, Klaus , FLIEGNER, Daniela , MONDRITZKI, Thomas , BOULTADAKIS ARAPINIS, Melissa , MARQUARDT, Tobias , VAKALOPOULOS, Alexandros , REBSTOCK, Anne-Sophie , WITTWER, Matthias
IPC分类号： A61K31/4375 , C07D471/04 , A61P9/06 , A61P13/12 , A61K31/4545 , A61K31/496 , A61K31/513 , A61K31/5377
摘要： Die vorliegende Anmeldung betrifft positiv allosterische Modulatoren des muskarinergen M2 Rezeptors, insbesondere solche, die gegenüber den verschiedenen muskarinergen Acetylcholin-Rezeptoren eine Subtyp-Selektivität für den M2-Rezeptor hinsichtlich der positiv-allosterischen Wirkung aufweisen, weiterhin deren Verwendung zur Behandlung und/oder Prävention von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prävention von Krankheiten, insbesondere zur Behandlung und/oder Prävention von kardiovaskulären Erkrankungen und/oder Nierenerkrankungen.
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公开(公告)号：EP3512849A1
公开(公告)日：2019-07-24
申请号：EP17772322.8
申请日：2017-09-06
发明人： TELLER, Henrik , VAKALOPOULOS, Alexandros , BOULTADAKIS ARAPINIS, Melissa , STRAUB, Alexander , TINEL, Hanna , BRECHMANN, Markus , WITTWER, Matthias, Beat , KULLMANN, Maximilian, Andreas , FREUDENBERGER, Till , MONDRITZKI, Thomas , MARQUARDT, Tobias
IPC分类号： C07D471/04 , C07D491/107 , A61K31/4375 , A61P9/00 , A61P13/00
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