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公开(公告)号：EP3532468A1
公开(公告)日：2019-09-04
申请号：EP17788234.7
申请日：2017-10-25
申请人： Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , The Broad Institute Inc. , President and Fellows of Harvard College , The General Hospital Corporation
发明人： GRADL, Stefan, Nikolaus , NGUYEN, Duy , EIS, Knut , GÜNTHER, Judith , STELLFELD, Timo , JANZER, Andreas , CHRISTIAN, Sven , MUELLER, Thomas , EL SHEIKH, Sherif El , ZHOU, Han, Jie , ZHAO, Changjia , SYKES, David Brian , FERRARA, Steven, James , LIU, Kery , KRÖBER, Michael , MERZ, Claudia , NIEHUES, Michael , SCHÄFER, Martina , ZIMMERMANN, Katja , NISING, Carl, Friedrich
IPC分类号： C07D403/12 , C07D401/12 , C07D405/12 , C07D413/12 , C07D249/12 , A61K31/4196 , A61P35/02
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公开(公告)号：EP3197891A1
公开(公告)日：2017-08-02
申请号：EP15766510.0
申请日：2015-09-22
发明人： ROEHRIG, Susanne , HILLISCH, Alexander , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , SCHÄFER, Martina , TELLER, Henrik , JIMÈNEZ NÙNEZ, Eloisa
IPC分类号： C07D471/04 , A61K31/55 , A61P7/02 , A61P27/02
CPC分类号： C07D471/04
摘要： The invention relates to substituted pyridobenzazepine and pyridobenzazocine derivatives and methods for the production thereof, as well as to the use thereof in the production of medicinal drugs for treating and/or preventing diseases, especially diseases of the cardiovascular system, preferably thrombotic or thromboembolic diseases, as well as oedemas, and also ophthalmological diseases.
摘要翻译： 本发明涉及取代的吡啶并苯并吖庚因和吡啶并苯并佐菌素衍生物及其制备方法，以及其在制备用于治疗和/或预防疾病，特别是心血管系统疾病，优选血栓形成或血栓栓塞性疾病的药物中的用途， 以及水肿，还有眼科疾病。
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公开(公告)号：EP3898634A1
公开(公告)日：2021-10-27
申请号：EP19832642.3
申请日：2019-12-18
发明人： RÖHRIG, Susanne , ESSIG, Sebastian , ELLERBROCK, Pascal , ANLAUF, Sonja , NEUBAUER, Thomas , HILLISCH, Alexander , MEIER, Katharina , HEITMEIER, Stefan , TERSTEEGEN, Adrian , SCHÄFER, Martina , STAMPFUSS, Jan , LANG, Dieter , JIMENEZ NUNEZ, Eloisa , ACKERSTAFF, Jens , TELLER, Henrik , ZOU, Zengqiang , LIU, Ping , MENG, Xianghai , LESSMANN, Frank
IPC分类号： C07D491/044 , A61K31/4353 , A61P9/00
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公开(公告)号：EP3197891B1
公开(公告)日：2018-11-21
申请号：EP15766510.0
申请日：2015-09-22
发明人： ROEHRIG, Susanne , HILLISCH, Alexander , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , SCHÄFER, Martina , TELLER, Henrik , JIMÈNEZ NÙNEZ, Eloisa
IPC分类号： C07D471/04 , A61K31/55 , A61P7/02 , A61P27/02
CPC分类号： C07D471/04
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公开(公告)号：EP3063150A1
公开(公告)日：2016-09-07
申请号：EP14789580.9
申请日：2014-10-28
发明人： RÖHRIG, Susanne , HILLISCH, Alexander , STRASSBURGER, Julia , HEITMEIER, Stefan , SCHMIDT, Martina, Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , BUCHMÜLLER, Anja , GERDES, Christoph , SCHÄFER, Martina , TELLER, Henrik , JIMENEZ NUNEZ, Eloisa , SCHIROK, Hartmut , KLAR, Jürgen
IPC分类号： C07D487/04 , A61K31/4188 , A61P7/02
CPC分类号： C07D471/04 , A61K31/437 , C07D487/04
摘要： The invention relates to substituted oxopyridine derivatives and methods for the production thereof, as well as to the use thereof in the production of medicinal drugs for treating and/or preventing diseases, especially diseases of the cardiovascular system, preferably thrombotic or thromboembolic diseases, as well as oedemas, and also ophthalmological diseases. The oxopyridine derivatives inhibit factor XIa and plasma kallicrein.
摘要翻译： 本发明涉及取代的氧代吡啶衍生物及其制备方法，以及它们用于制备用于治疗和/或预防疾病，特别是心血管疾病，优选血栓形成或血栓栓塞性疾病，以及odemas以及眼科疾病的药物的用途 。
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公开(公告)号：EP3049390A1
公开(公告)日：2016-08-03
申请号：EP14771910.8
申请日：2014-09-24
发明人： RÖHN, Ulrike , ELLERMANN, Manuel , STRASSBURGER, Julia , WENDT, Astrid , RÖHRIG, Susanne , WEBSTER, Robert, Alan , SCHMIDT, Martina, Victoria , TERSTEEGEN, Adrian , BEYER, Kristin , SCHÄFER, Martina , BUCHMÜLLER, Anja , GERDES, Christoph , SPERZEL, Michael , SANDMANN, Steffen , HEITMEIER, Stefan , HILLISCH, Alexander , ACKERSTAFF, Jens , TERJUNG, Carsten
IPC分类号： C07D209/42 , A61P7/02 , A61K31/16 , C07D231/56 , C07D235/08 , C07D235/26 , C07D249/08 , C07D249/10 , C07D257/04 , C07D263/58 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12
CPC分类号： C07D401/12 , C07D209/42 , C07D231/56 , C07D235/08 , C07D235/26 , C07D249/04 , C07D249/08 , C07D249/10 , C07D257/04 , C07D263/58 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , C07D451/04 , C07D487/04
摘要： The invention relates to substituted phenylalanine derivatives and to methods for the production thereof, in addition to the use of said derivatives for producing drugs for the treatment and/or prophylaxis of diseases, in particular cardiovascular diseases and/or perioperative heavy blood loss.
摘要翻译： 除了使用所述衍生物生产用于治疗和/或预防疾病，特别是心血管疾病和/或围手术期严重失血的药物之外，本发明涉及取代的苯丙氨酸衍生物和其制备方法。
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公开(公告)号：EP2847190B1
公开(公告)日：2016-04-06
申请号：EP13720407.9
申请日：2013-05-03
发明人： FÜRSTNER, Chantal , ACKERSTAFF, Jens , STRAUB, Alexander , MEIER, Heinrich , TINEL, Hanna , ZIMMERMANN, Katja , TERSTEEGEN, Adrian , ZUBOV, Dmitry , KAST, Raimund , SCHAMBERGER, Jens , SCHÄFER, Martina , BÖRNGEN, Kirsten
IPC分类号： C07D413/14 , C07D401/04 , C07D403/04 , C07D409/14 , C07D413/04 , C07D417/04 , C07D471/04 , A61K38/04
CPC分类号： A61K31/513 , A61K31/506 , A61K31/536 , A61K31/538 , A61K45/06 , C07D401/04 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D471/04
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公开(公告)号：EP3793559A1
公开(公告)日：2021-03-24
申请号：EP19725298.4
申请日：2019-05-10
发明人： MÜLLER, Steffen , SCHOHE-LOOP, Rudolf , ORTEGA, HERNANDEZ, Nuria , SÜSSMEIER, Frank , JIMENEZ NUNEZ, Eloisa , BRUMBY, Thomas , LINDNER, Niels , GERDES, Christoph , POOK, Elisabeth , BUCHMÜLLER, Anja , GAUGAZ, Fabienne, Zdenka , LANG, Dieter , ZIMMERMANN, Stefanie , EHRMANN, Alexander, Helmut, Michael , GERISCH, Michael , LEHMANN, Lutz , TIMMERMANN, Andreas , SCHÄFER, Martina , SCHMIDT, Georg , SCHLEMMER, Karl-Heinz , FOLLMANN, Markus , KERSTEN, Elisabeth , WANG, Vivian , GAO, Xiang , WANG, Yafeng
IPC分类号： A61K31/4985 , C07D487/04 , A61P27/02 , A61P7/00
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公开(公告)号：EP3707141A1
公开(公告)日：2020-09-16
申请号：EP18800549.0
申请日：2018-10-31
发明人： BIBER, Nicole , BROCKSCHNIEDER, Damian , KÖLLING, Florian , MEDING, Jörg , MIYATAKE ONDOZABAL, Hideki , NEUBAUER, Thomas , SCHÄFER, Martina , ZUBOV, Dmitry , TERJUNG, Carsten
IPC分类号： C07D487/04 , A61K31/519 , A61P11/00
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10.发明授权
公开(公告)号：EP2978756B1
公开(公告)日：2019-03-27
申请号：EP14713452.2
申请日：2014-03-27
发明人： RÖHRIG, Susanne , HILLISCH, Alexander , STRAßBURGER, Julia , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , BUCHMÜLLER, Anja , GERDES, Christoph , SCHÄFER, Martina , KINZEL, Tom , TELLER, Henrik , SCHIROK, Hartmut , KLAR, Jürgen , JIMENEZ NUNEZ, Eloisa
IPC分类号： C07D413/14 , C07D213/85 , C07D401/12 , C07D405/06 , C07D409/06 , C07D413/12 , C07D417/12 , C07D213/64 , C07D213/69 , A61K31/4427 , A61K31/4412 , A61K31/4418 , A61P7/00 , A61P9/00
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