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公开(公告)号：EP3008062B1
公开(公告)日：2017-04-05
申请号：EP14728949.0
申请日：2014-06-06
发明人： SCHULZE, Volker , LERCHEN, Hans-Georg , BIERER, Donald , WENGNER, Antje Margret , SIEMEISTER, Gerhard , LIENAU, Philip , KRENZ, Ursula , KOSEMUND, Dirk , STÖCKIGT, Detlef , BRÜNING, Michael , LÜCKING, Ulrich , TEREBESI, Ildikó
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61K38/00 , C07F9/6561 , C07K5/062 , C07K5/068
CPC分类号： C07D471/04 , A61K38/00 , C07F9/6561 , C07K5/06052 , C07K5/06086
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2.发明公开PRODRUG DERIVATIVES OF SUBSTITUTED TRIAZOLOPYRIDINES 有权PRODRUGDERIVATE AUS SUBSTITUIERTEN TRIAZOLOPYRIDINEN
公开(公告)号：EP3008062A2
公开(公告)日：2016-04-20
申请号：EP14728949.0
申请日：2014-06-06
发明人： SCHULZE, Volker , LERCHEN, Hans-Georg , BIERER, Donald , WENGNER, Antje Margret , SIEMEISTER, Gerhard , LIENAU, Philip , KRENZ, Ursula , KOSEMUND, Dirk , STÖCKIGT, Detlef , BRÜNING, Michael , LÜCKING, Ulrich , TEREBESI, Ildikó
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , A61K38/00 , C07F9/6561 , C07K5/06052 , C07K5/06086
摘要： The present invention relates to prodrug derivatives of Mps-1 kinase inhibitors, processes for their preparation, and their use for the treatment and/or prophylaxis of diseases.
摘要翻译： 本发明涉及Mps-1激酶抑制剂的前药衍生物，其制备方法及其用于治疗和/或预防疾病的用途。
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3.发明公开
公开(公告)号：EP2464331A1
公开(公告)日：2012-06-20
申请号：EP10742494.7
申请日：2010-08-11
发明人： GENERAL, Sascha , TEREBESI, Ildikó , FUNKE, Adrian
IPC分类号： A61K9/00 , A61K9/50 , A61K31/519 , A61K31/57 , A61K31/585 , A61K45/06
CPC分类号： A61K31/519 , A61K9/0056 , A61K9/006 , A61K9/5015 , A61K9/7007 , A61K31/57 , A61K31/585 , A61K45/06 , A61K47/32 , A61K47/36 , A61K47/42 , A61K47/44 , A61K2300/00
摘要： The present invention relates to small stabilised particles comprising a crystalline form of an alkaline earth metal salt of 5-methyl-(6S)-tetrahydrofolate and at least one protective agent. Such particles confer stability to the alkaline earth metal salt of 5-methyl-(6S)-tetrahydrofolate, and is conveniently incorporated in unit dosage forms, such as wafers.
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