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公开(公告)号：EP2951174B1
公开(公告)日：2017-04-26
申请号：EP14701566.3
申请日：2014-01-28
发明人： BÄRFACKER, Lars , PRECHTL, Stefan , SIEMEISTER, Gerhard , WENGNER, Antje Margret , ACKERSTAFF, Jens , NOWAK-REPPEL, Katrin , BADER, Benjamin , LIENAU, Philip , STÖCKIGT, Detlef , HEINRICH, Tobias
IPC分类号： C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D513/04 , A61K31/497 , A61P35/00
CPC分类号： C07D495/04 , C07D417/12 , C07D417/14 , C07D487/04 , C07D513/04
摘要： The present invention relates to isothiazoles of general formula (I) which inhibit the mitotic checkpoint: in which A, R1 and R2 are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及抑制有丝分裂检查点的通式（I）的异噻唑：其中A，R 1和R 2如权利要求中所定义，涉及制备所述化合物的方法，可用于制备所述化合物的中间体化合物， 包含所述化合物的组合物和组合以及所述化合物用于制备用于治疗或预防疾病，特别是赘生物，作为唯一试剂或与其它活性成分组合的药物组合物的用途。
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公开(公告)号：EP3008062B1
公开(公告)日：2017-04-05
申请号：EP14728949.0
申请日：2014-06-06
发明人： SCHULZE, Volker , LERCHEN, Hans-Georg , BIERER, Donald , WENGNER, Antje Margret , SIEMEISTER, Gerhard , LIENAU, Philip , KRENZ, Ursula , KOSEMUND, Dirk , STÖCKIGT, Detlef , BRÜNING, Michael , LÜCKING, Ulrich , TEREBESI, Ildikó
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00 , A61K38/00 , C07F9/6561 , C07K5/062 , C07K5/068
CPC分类号： C07D471/04 , A61K38/00 , C07F9/6561 , C07K5/06052 , C07K5/06086
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公开(公告)号：EP2852596B1
公开(公告)日：2016-06-22
申请号：EP13725935.4
申请日：2013-05-17
发明人： KETTSCHAU, Georg , PÜHLER, Florian , EIS, Knut , KLAR, Ulrich , KOSEMUND, Dirk , SÜLZLE, Detlev , LIENAU, Philip , HÄGEBARTH, Andrea , BÖMER, Ulf , WORTMANN, Lars , GRAHAM, Keith , WENGNER, Antje Margret
IPC分类号： C07D495/04 , C07D519/00 , A61K31/519 , A61P35/00
CPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/5513 , A61K45/06 , C07D519/00
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公开(公告)号：EP2961752A2
公开(公告)日：2016-01-06
申请号：EP14706569.2
申请日：2014-02-25
发明人： KOPPITZ, Marcus , KLAR, Ulrich , WENGNER, Antje Margret , NEUHAUS, Roland , SIEMEISTER, Gerhard , BRÜNING, Michael
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , A61K31/282 , A61K31/4188 , A61K31/5025 , A61K31/52 , A61K31/573 , A61K31/675 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K38/14 , A61K39/3955 , A61K2039/505 , C07D237/00
摘要： The present invention relates to substituted imidazopyridazine compounds, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
摘要翻译： 本发明涉及取代的咪唑并哒嗪化合物，制备所述化合物的方法，药物组合物和包含所述化合物的组合，以及所述化合物用于制备药物组合物用于治疗或预防疾病，特别是超 增殖和/或血管生成障碍，作为唯一的药剂或与其它活性成分组合。
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公开(公告)号：EP2961752B1
公开(公告)日：2017-09-13
申请号：EP14706569.2
申请日：2014-02-25
发明人： KOPPITZ, Marcus , KLAR, Ulrich , WENGNER, Antje Margret , NEUHAUS, Roland , SIEMEISTER, Gerhard , BRÜNING, Michael
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , A61K31/282 , A61K31/4188 , A61K31/5025 , A61K31/52 , A61K31/573 , A61K31/675 , A61K31/69 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K38/14 , A61K39/3955 , A61K2039/505 , C07D237/00
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6.发明公开SUBSTITUTED TRIAZOLOPYRIDINES HAVING ACTIVITY AS MPS-1 INHIBITORS 审中-公开替补三唑吡啶麻醉剂WIRKUNG ALS MPS-1-INHIBITOREN
公开(公告)号：EP3004093A1
公开(公告)日：2016-04-13
申请号：EP14727536.6
申请日：2014-06-03
发明人： SCHULZE, Volker K. , SCHALL, Andreas , BRIEM, Hans , WENGNER, Antje Margret , SIEMEISTER, Gerhard , STÖCKIGT, Detlef , LIENAU, Philip
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04 , C07D333/54 , C07F5/025 , C07F5/04
摘要： The present invention relates to substituted triazolopyridine compounds of general formula (I), in which R
1 , R
2 , R
3 , R
4 , and R
5 are as given in the description and in the claims, to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.摘要翻译： 本发明涉及通式（I）的取代的三唑并吡啶化合物，其中R 1，R 2，R 3，R 4和R 5如说明书和权利要求书中所述，涉及制备所述化合物的方法，药物组合物和组合 包括所述化合物，所述化合物用于制备用于治疗或预防疾病的药物组合物，以及可用于制备所述化合物的中间体化合物。
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公开(公告)号：EP2791136B1
公开(公告)日：2015-07-29
申请号：EP12805516.7
申请日：2012-12-10
发明人： SCHULZE, Volker , KOSEMUND, Dirk , WENGNER, Antje Margret , SIEMEISTER, Gerhard , STÖCKIGT, Detlef , BRUENING, Michael
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/437 , A61K31/7028 , A61K45/06
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公开(公告)号：EP2852596A1
公开(公告)日：2015-04-01
申请号：EP13725935.4
申请日：2013-05-17
发明人： KETTSCHAU, Georg , PÜHLER, Florian , EIS, Knut , KLAR, Ulrich , KOSEMUND, Dirk , SÜLZLE, Detlev , LIENAU, Philip , HÄGEBARTH, Andrea , BÖMER, Ulf , WORTMANN, Lars , GRAHAM, Keith , WENGNER, Antje Margret
IPC分类号： C07D495/04 , C07D519/00 , A61K31/519 , A61P35/00
CPC分类号： C07D495/04 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/5513 , A61K45/06 , C07D519/00
摘要： The present invention relates to substituted thienopyrimidine compounds of general formula (I) as described and defined herein, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and /or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
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公开(公告)号：EP3288558A1
公开(公告)日：2018-03-07
申请号：EP16723280.0
申请日：2016-04-29
发明人： BOTHE, Ulrich , WENGNER, Antje Margret , SIEBENEICHER, Holger , SCHMIDT, Nicole , NUBBEMEYER, Reinhard , BÖMER, Ulf , GÜNTHER, Judith , STEUBER, Holger , LANGE, Martin , STEGMANN, Christian , SUTTER, Andreas , NEUHAUS, Roland
IPC分类号： A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , C07D401/12 , A61P35/02 , A61P35/00
CPC分类号： A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K45/06 , A61P35/00 , A61K2300/00
摘要： The present application relates to novel combinations of at least two components, component A and component B: ⋅component A is an IRAK4-inhibiting compound of the formula (I) as defined herein, or a diastereomer, an enantiomer, a metabolite, a salt, a solvate or a solvate of a salt thereof; ⋅component B is a BTK-inhibiting compound, or a pharmaceutically acceptable salt thereof; and, optionally, ⋅one or more components C which are pharmaceutical products; in which one or two of the above-defined compounds A and B are optionally present in pharmaceutical formulations ready for simultaneous, separate or sequential administration, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of endometriosis, lymphoma, macular degeneration, COPD, neoplastic disorders and psoriasis.
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公开(公告)号：EP2825540B1
公开(公告)日：2016-09-14
申请号：EP13710986.4
申请日：2013-03-11
发明人： KOPPITZ, Marcus , KLAR, Ulrich , WENGNER, Antje Margret , NEUHAUS, Roland , SIEMEISTER, Gerhard
IPC分类号： C07D487/04 , A61K31/5025 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5025 , A61K45/06
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