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公开(公告)号：EP4456871A1
公开(公告)日：2024-11-06
申请号：EP22844518.5
申请日：2022-12-28
发明人： MUNDRY, Tobias , TEREBESI, Ildiko , RICHTER, Annett , OLENIK, Britta , KEIL, Birgit , RÖSLER, Bernd , FEY, Peter , SCHIRMER, Heiko , BECKER, Guido , BOTHE, Clemens , FABER, Helene , EGGER, Julian , BECKER-PELSTER, Eva Maria , TINEL, Hanna , HAHN, Michael , LANG, Dieter , WEIMANN, Gerrit , NAGELSCHMITZ, Johannes , DIETZ, Lisa , SALEH, Soundos , JUNG, David , PARRY, Mark , WARD, David , VITRE, Cecile
IPC分类号： A61K9/00 , A61K9/14 , A61K31/4709
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公开(公告)号：EP4456896A1
公开(公告)日：2024-11-06
申请号：EP22844517.7
申请日：2022-12-28
发明人： BECKER-PELSTER, Eva, Maria , TINEL, Hanna , HAHN, Michael , LANG, Dieter , WEIMANN, Gerrit , NAGELSCHMITZ, Johannes , DIETZ, Lisa , SALEH, Soundos , JUNG, David , TEREBESI, Ildiko , MUNDRY, Tobias , RICHTER, Annett , OLENIK, Britta , KEIL, Birgit , RÖSLER, Bernd , FEY, Peter , SCHIRMER, Heiko , BECKER, Guido , BOTHE, Clemens , FABER, Helene , EGGER, Julian , PARRY, Mark , WARD, David , VITRE, Cecile
IPC分类号： A61K31/4709 , A61K9/00 , A61P11/08
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公开(公告)号：EP2358351A1
公开(公告)日：2011-08-24
申请号：EP09753046.3
申请日：2009-11-13
发明人： TEREBESI, Ildiko , FUNKE, Adrian , DIEFENBACH, Konstanze , SCHÄFERS, Matthias , GENERAL, Sascha
IPC分类号： A61K9/00 , A61K31/565 , A61K9/70
CPC分类号： A61K9/006 , A61K9/7007
摘要： The present invention relates to drug delivery systems in the form of thin water-soluble films (wafers), which contain an Estrogen Receptor beta (ER-β) selective agonist. The wafers of the present invention are suitable for treating, alleviating or preventing a physical condition in a female mammal caused by insufficient endogenous levels of estrogen.
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公开(公告)号：EP3464288A1
公开(公告)日：2019-04-10
申请号：EP17725242.6
申请日：2017-05-23
发明人： KOPPITZ, Marcus , SIEBENEICHER, Holger , STEUBER, Holger , TER LAAK, Antonius , NUBBEMEYER, Reinhard , ROTTMANN, Antje , IRLBACHER, Horst , BADER, Benjamin , PETERS, Michaele , WAGENFELD, Andrea , TEREBESI, Ildiko
IPC分类号： C07D487/08 , A61K31/498 , A61P15/00 , A61P29/00 , A61P35/00
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5.发明授权NEUE 5-AMINOTETRAHYDROCHINOLIN-2-CARBONSÄUREN UND IHRE VERWENDUNG 有权新的5 AMINOTETRAHYDROCHINOLIN -2-羧酸及其用途
公开(公告)号：EP2875003B1
公开(公告)日：2016-11-16
申请号：EP13744464.2
申请日：2013-07-16
发明人： HAHN, Michael , FOLLMANN, Markus , HÜBSCH, Walter , BECKER-PELSTER, Eva-Maria , STASCH, Johannes-Peter , KELDENICH, Joerg , DELBECK, Martina , TINEL, Hanna , WUNDER, Frank , MITTENDORF, Joachim , TEREBESI, Ildiko , LANG, Dieter , MARTIN, René
IPC分类号： C07D217/26 , C07D401/12 , C07D413/12 , A61K31/47 , A61P9/00
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K45/06 , C07D217/26 , C07D401/12 , C07D413/12
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6.发明公开NEUE 5-AMINOTETRAHYDROCHINOLIN-2-CARBONSÄUREN UND IHRE VERWENDUNG 有权新的5 AMINOTETRAHYDROCHINOLIN -2-羧酸及其用途
公开(公告)号：EP2875003A1
公开(公告)日：2015-05-27
申请号：EP13744464.2
申请日：2013-07-16
发明人： HAHN, Michael , FOLLMANN, Markus , HÜBSCH, Walter , BECKER-PELSTER, Eva-Maria , STASCH, Johannes-Peter , KELDENICH, Joerg , DELBECK, Martina , TINEL, Hanna , WUNDER, Frank , MITTENDORF, Joachim , TEREBESI, Ildiko , LANG, Dieter , MARTIN, René
IPC分类号： C07D217/26 , C07D401/12 , C07D413/12 , A61K31/47 , A61P9/00
CPC分类号： C07D215/48 , A61K31/47 , A61K31/4706 , A61K31/4709 , A61K45/06 , C07D217/26 , C07D401/12 , C07D413/12
摘要： The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
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公开(公告)号：EP2467126A1
公开(公告)日：2012-06-27
申请号：EP10745182.5
申请日：2010-08-19
发明人： GENERAL, Sascha , TEREBESI, Ildiko , FUNKE, Adrian
CPC分类号： A61K9/7007 , A61K9/006 , A61K9/14 , A61K9/146 , A61K9/1635 , A61K9/5176
摘要： The present invention describes drug delivery compositions in the form of thin water-soluble films (wafers), which contain particles that comprise at least one active ingredient -which is not an estrogen and/or a progestin and/or an alkaline earth metal salt of 5-methyl-(6S)-tetrahydrofolate- and at least one protective agent. The protective agent provides effective taste-masking of the active ingredient due to limited release of the active ingredient in the mouth. The active ingredient is hence not absorbed via the buccal route, but rather via the enteral (per-oral) route. The particles contained in the wafer provided by the present invention have a particle size of below 40 μm thereby resulting in an acceptable sensation in the mouth while dissolving. Such wafers are especially suitable for pediatric use.
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