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公开(公告)号：EP4419081A1
公开(公告)日：2024-08-28
申请号：EP22803430.2
申请日：2022-10-19
发明人： MOSAHEB, Munir , PATEL, Siddharth , ARAFA, Emad , BOGORAD, Roman
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公开(公告)号：EP3272398A1
公开(公告)日：2018-01-24
申请号：EP17188300.2
申请日：2011-03-24
申请人： Lipotec S.A.
CPC分类号： A61K8/922 , A61K8/0283 , A61K8/11 , A61K8/342 , A61K8/37 , A61K8/375 , A61K8/39 , A61K8/553 , A61K8/602 , A61K8/73 , A61K8/735 , A61K8/97 , A61K9/0014 , A61K9/1075 , A61K9/127 , A61K9/5123 , A61K9/5176 , A61K2800/413 , A61Q1/04 , A61Q1/06 , A61Q1/10 , A61Q1/12 , A61Q1/14 , A61Q3/00 , A61Q5/00 , A61Q19/001
摘要： Delivery system for active ingredients which comprises lipid nanoparticles, such as solid lipid nanoparticles (SLN) or nanostructured lipid carriers (NLC), polymerically coated, and their use in the preparation of pharmaceutical, cosmetic and/or alimentary compositions.
摘要翻译： 包含脂质纳米粒子（例如固体脂质纳米粒子（SLN）或纳米结构脂质载体（NLC））的聚合物包衣的活性成分的递送系统及其在制备药物，化妆品和/或营养组合物中的用途。
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3.发明公开
公开(公告)号：EP2633862A4
公开(公告)日：2014-12-03
申请号：EP11835368
申请日：2011-10-27
CPC分类号： A61K9/14 , A01N25/28 , A01N65/00 , A61K8/0241 , A61K8/988 , A61K9/5176 , A61K9/5192 , A61K31/65 , A61K31/7052 , A61K35/644 , A61K36/00 , A61K2800/10 , A61Q19/00 , B82Y40/00 , Y10S977/84 , A01N37/44 , A01N43/46 , A01N65/28 , A01N25/04 , A01N37/46
摘要： The present invention relates to a process for obtaining compositions constituted by propolis nanoparticles and to the use thereof, said nanoparticles being optionally associated to one or more substances of interest such as active ingredients, as well as, optionally, substances of secondary effect such as synergists and adjuvants. The process for obtaining the nanoparticles comprises the steps of preparing a fraction A, which consists of propolis extract dissolved in an organic solvent, to which one or m ore stabilizers and/or emulsifiers may be added, as well as, optionally, one or more substances of interest and/or of secondary effect; ii) preparing a fraction B, aqueous phase, constituted by: (ii.1) water; or (ii.2) an aqueous solution or dispersion, to which one or more stabilizers and/or emulsifiers may be added; (iii) drooping the fraction A onto the fraction B or the fraction B onto the fraction A; iv) homogenizing the mixture by mechanical stirring and spontaneous formation of nanoaprticles with average size ranging from 1 to 1000 nm in a dispersion; v) optionally the following additional steps may be involved: (v-1) removing the organic solvent/ and/or (v-2) drying the nanodispersion. The developed compositions have applications in fields such as agrochemical, pharmaceutical, cosmetic or chemical fields.
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公开(公告)号：EP2547329A4
公开(公告)日：2014-06-25
申请号：EP11757011
申请日：2011-03-17
申请人： UNIV TEXAS
CPC分类号： A61K9/14 , A61K9/0019 , A61K9/1271 , A61K9/5068 , A61K9/5115 , A61K9/5123 , A61K9/5176 , A61K49/00
摘要： The present invention pertains to therapeutic compositions and delivery systems comprising at least one microparticle or nanoparticle. In various embodiments, the surface of the microparticle or nanoparticle is modified or functionalized with at least a portion of an isolated cellular membrane, such as an isolated plasma membrane. In addition, the microparticle or nanoparticle contains at least one active agent, such as a therapeutic and/or imaging agent. In additional embodiments, the compositions and delivery systems of the present invention may be used for targeted delivery of an active agent. Also provided are methods of making the therapeutic compositions and delivery systems of the present invention.
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公开(公告)号：EP4440556A2
公开(公告)日：2024-10-09
申请号：EP22902192.8
申请日：2022-12-01
申请人： Spoke Sciences, Inc.
发明人： MITCHNICK, Mark
CPC分类号： A61K9/10 , A61K9/5176 , A61K47/22 , A61K31/658
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公开(公告)号：EP2549977A2
公开(公告)日：2013-01-30
申请号：EP11711041.1
申请日：2011-03-24
申请人： Lipotec, S.A.
IPC分类号： A61K8/11
CPC分类号： A61K8/922 , A61K8/0283 , A61K8/11 , A61K8/342 , A61K8/37 , A61K8/375 , A61K8/39 , A61K8/553 , A61K8/602 , A61K8/73 , A61K8/735 , A61K8/97 , A61K9/0014 , A61K9/1075 , A61K9/127 , A61K9/5123 , A61K9/5176 , A61K2800/413 , A61Q1/04 , A61Q1/06 , A61Q1/10 , A61Q1/12 , A61Q1/14 , A61Q3/00 , A61Q5/00 , A61Q19/001
摘要： Delivery system for active ingredients which comprises lipid nanoparticles, such as solid lipid nanoparticles (SLN) or nanostructured lipid carriers (NLC), polymerically coated, and their use in the preparation of pharmaceutical, cosmetic and/or alimentary compositions.
摘要翻译： 用于活性成分的递送系统，其包含脂质纳米颗粒，例如固体脂质纳米颗粒（SLN）或聚合物涂覆的纳米结构脂质载体（NLC），以及它们在制备药物，化妆品和/或营养组合物中的用途。
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公开(公告)号：EP2496265A1
公开(公告)日：2012-09-12
申请号：EP09744895.5
申请日：2009-11-02
IPC分类号： A61K47/48 , A61K9/51 , A61K39/385
CPC分类号： A61K9/5184 , A61K9/1652 , A61K9/1664 , A61K9/5068 , A61K9/5176 , A61K39/00 , A61K47/16 , A61K47/18 , A61K47/34 , A61K47/46 , A61K47/61 , A61K2039/60 , A61K2039/6087
摘要： Described are a method and a composition for delivery of a protein to an antigen presenting cell. The composition is composed of a polypeptide component, a buffering component and a particle to be phagocytized. In one embodiment, the antigen presenting cell is aa macrophage or a dendritic cell and the particle to be phagocytized is from a natural source, such as from a microbial source. The composition itself, or cells pretreated with the composition, are useful for strategies in vaccine development.
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8.发明公开LIPOSOMAL COMPOSITIONS AND USES OF SAME 有权ZUSAMMENSETZUNGEN ENDALTEND LIPOSOMEN UND DEREN VERWENDUNG
公开(公告)号：EP2470164A2
公开(公告)日：2012-07-04
申请号：EP10761069.3
申请日：2010-08-26
IPC分类号： A61K9/127
CPC分类号： A61K9/5176 , A61K9/1271 , A61K47/6901 , A61K47/6911 , C12N15/88
摘要： Compositions comprising liposomes composed of whole cell membrane fraction are provided. The liposomes may be attached to, or encapsulate a pharmaceutical agent. Also provided are methods of generating and using these liposomes.
摘要翻译： 提供包含由全细胞膜级分组成的脂质体的组合物。 脂质体可以连接到或封装药剂。 还提供了产生和使用这些脂质体的方法。
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公开(公告)号：EP2205225A1
公开(公告)日：2010-07-14
申请号：EP08836300.7
申请日：2008-09-30
发明人： KUNDU, Tapas, Kumar , MUTHUSAMY, Eswaramoorthy , VIKRU, Ruthrotha, Selvi, Bharatha , JAGADEESAN, Dinesh
CPC分类号： A61K9/5115 , A61K9/5176 , A61K9/5192 , A61K31/235 , A61K47/00 , C07C235/64
摘要： The present invention provides solution to the problem involved in delivery of active molecules to nucleus. More particularly, the invention provides intrinsically fluorescent and inherently surface functionalized carbon nanospheres which are non-toxic. Also, these carbon nanospheres [CSP] were adsorbed with CTPB [CSP-CTPB] and the adsorbed CSP-CTPB are permeable to cells with nuclear targeting ability. In addition, the present invention provides a composition, a process to prepare the composition comprising CSP with adsorbed active/ therapeutic molecules. Further, the instant invention provides a method for delivering active molecules inside a cell nucleus.
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公开(公告)号：EP0684812A1
公开(公告)日：1995-12-06
申请号：EP94909762.0
申请日：1994-02-10
CPC分类号： A61K9/5176 , A61K9/127 , A61K9/1664 , G01N33/586
摘要： An encapsulated microparticle composition and its method of use in drug delivery and diagnostic applications are disclosed. Also disclosed are methods of storing and administering drug compounds at high concentration in condensed-phase microparticles.
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