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公开(公告)号：EP3144323A2
公开(公告)日：2017-03-22
申请号：EP16191498.1
申请日：2010-12-08
发明人： LINDEN, Lars , CAO, Yong-Jiang , LEDER, Gabriele , STELTE-LUDWIG, Beatrix , HARRENGA, Axel , FINNERN, Ricarda , DITTMER, Frank , MAYER-BARTSCHMID, Anke , FRANZ, Juergen , GREVEN, Simone , WILLUDA, Jörg , TEBBE, Jan
IPC分类号： C07K16/30 , A61K39/395 , G01N33/53 , A61P35/00
CPC分类号： C07K16/30 , A61K39/39558 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 29 kDa polypeptide named C4.4a , which is over expressed in tumors.
C4.4a has a high abundance in metastases of several cancer types. The antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of C4.4a in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.摘要翻译： 本发明提供了重组抗原结合区和抗体以及含有此类抗原结合区的功能性片段，所述抗原结合区对于在肿瘤中过度表达的膜锚定的，称为C4.4a的29kDa多肽是特异性的。 C4.4a在几种癌症类型的转移中具有高丰度。 因此，抗体可用于治疗这些和其他病症和病症。 本发明的抗体也可以用于诊断领域，以及用于进一步研究C4.4a在与癌症相关的病症发展中的作用。 本发明还提供编码前述抗体的核酸序列，含有其的载体，药物组合物和具有使用说明书的试剂盒。
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公开(公告)号：EP3274370A2
公开(公告)日：2018-01-31
申请号：EP16713784.3
申请日：2016-03-21
发明人： WILLUDA, Jörg , TRAUTWEIN, Mark , GRITZAN, Uwe , FREIBERG, Christoph , DITTMER, Frank , SCHÖNFELD, Dorian , GLÜCK, Julian, Marius , PINKERT, Jessica , GUTIERREZ Eva-Maria , GOLFIER, Sven , HOLTON, Simon , BECKHOVE, Philip , GE, Yingzi
摘要： The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for human and Macaca fascicularis CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6, CD66c, Non-specific crossreacting antigen, NCA, NCA-50/90), and which do not significantly cross-react with the closely related human CEACAM1, human CEACAM3, and human CEACAM5. The invention further provides methods to generate this kind of antibodies. The antibodies, accordingly, can be used to treat cancer and other disorders and conditions associated with expression of the CEACAM6. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
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公开(公告)号：EP2510012B1
公开(公告)日：2017-04-19
申请号：EP10798996.4
申请日：2010-12-08
发明人： LINDEN, Lars , CAO, Yong-Jiang , LEDER, Gabriele , STELTE-LUDWIG, Beatrix , HARRENGA, Axel , FINNERN, Ricarda , DITTMER, Frank , MAYER-BARTSCHMID, Anke , FRANZ, Juergen , GREVEN, Simone , WILLUDA, Jörg , TEBBE, Jan
IPC分类号： C07K16/30 , A61K39/395 , G01N33/53 , A61P35/00
CPC分类号： C07K16/30 , A61K39/39558 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92
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公开(公告)号：EP3144323A3
公开(公告)日：2017-05-31
申请号：EP16191498.1
申请日：2010-12-08
发明人： LINDEN, Lars , CAO, Yong-Jiang , LEDER, Gabriele , STELTE-LUDWIG, Beatrix , HARRENGA, Axel , FINNERN, Ricarda , DITTMER, Frank , MAYER-BARTSCHMID, Anke , FRANZ, Juergen , GREVEN, Simone , WILLUDA, Jörg , TEBBE, Jan
IPC分类号： C07K16/30 , A61K39/395 , G01N33/53 , A61P35/00
CPC分类号： C07K16/30 , A61K39/39558 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 29 kDa polypeptide named C4.4a , which is over expressed in tumors.
C4.4a has a high abundance in metastases of several cancer types. The antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of C4.4a in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.摘要翻译： 本发明提供重组抗原结合区和抗体以及含有这样的抗原结合区的功能片段，所述抗原结合区对于在肿瘤中过表达的膜锚定的29kDa多肽（称为C4.4a）是特异性的。 C4.4a在几种癌症类型的转移灶中具有高丰度。 因此，抗体可以用于治疗这些和其他疾病和病症。 本发明的抗体也可用于诊断领域，以及用于进一步研究C4.4a在与癌症相关疾病进展中的作用。 本发明还提供编码前述抗体的核酸序列，含有该抗体的载体，药物组合物和具有使用说明书的试剂盒。
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公开(公告)号：EP2510012A1
公开(公告)日：2012-10-17
申请号：EP10798996.4
申请日：2010-12-08
发明人： LINDEN, Lars , CAO, Yong-Jiang , LEDER, Gabriele , STELTE-LUDWIG, Beatrix , HARRENGA, Axel , FINNERN, Ricarda , DITTMER, Frank , MAYER-BARTSCHMID, Anke , FRANZ, Juergen , GREVEN, Simone , WILLUDA, Jörg , TEBBE, Jan
IPC分类号： C07K16/30 , A61K39/395 , G01N33/53 , A61P35/00
CPC分类号： C07K16/30 , A61K39/39558 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 29 kDa C4.4a polypeptide, which is over expressed in several tumors, e.g. lung, colorectal, pancreas, prostate, renal and breast cancer. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of C4.4a in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
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公开(公告)号：EP3274370B1
公开(公告)日：2019-11-20
申请号：EP16713784.3
申请日：2016-03-21
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