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公开(公告)号：EP3274370A2
公开(公告)日：2018-01-31
申请号：EP16713784.3
申请日：2016-03-21
发明人： WILLUDA, Jörg , TRAUTWEIN, Mark , GRITZAN, Uwe , FREIBERG, Christoph , DITTMER, Frank , SCHÖNFELD, Dorian , GLÜCK, Julian, Marius , PINKERT, Jessica , GUTIERREZ Eva-Maria , GOLFIER, Sven , HOLTON, Simon , BECKHOVE, Philip , GE, Yingzi
摘要： The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for human and Macaca fascicularis CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6, CD66c, Non-specific crossreacting antigen, NCA, NCA-50/90), and which do not significantly cross-react with the closely related human CEACAM1, human CEACAM3, and human CEACAM5. The invention further provides methods to generate this kind of antibodies. The antibodies, accordingly, can be used to treat cancer and other disorders and conditions associated with expression of the CEACAM6. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
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公开(公告)号：EP3274370B1
公开(公告)日：2019-11-20
申请号：EP16713784.3
申请日：2016-03-21
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公开(公告)号：EP3313522A1
公开(公告)日：2018-05-02
申请号：EP16733024.0
申请日：2016-06-20
发明人： LERCHEN, Hans-Georg , REBSTOCK, Anne-Sophie , CANCHO GRANDE, Yolanda , WITTROCK, Sven , BERNDT, Sandra , GRITZAN, Uwe , FITTING, Jenny , STELTE-LUDWIG, Beatrix , JONES, Patrick , MAHLERT, Christoph , VOTSMEIER, Christian , SCHÖNFELD, Dorian , TRAUTWEIN, Mark , WEBER, Ernst , PAWLOWSKI, Nikolaus , GREVEN, Simone , GLÜCK, Julian Marius , HAMMER, Stefanie , DIETZ, Lisa , MÄRSCH, Stephan
IPC分类号： A61P35/00
CPC分类号： A61K47/6865 , A61K47/6803 , A61K47/6849 , A61K47/6855 , A61K47/6857 , A61K47/6863
摘要： The invention relates to novel antibody drug conjugates (ADCs), active metabolites of said ADCs, to methods for producing said ADCs, to the use of said ADCs for the treatment and/or prevention of diseases, and to the use of said ADCs for the production of medicaments for the treatment and/or prevention of diseases, in particular hyperproliferative and angiogenic diseases, such as cancer diseases. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
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